科普專欄–薯不揀單 - 三十秒科學–腫瘤的周遭環境

教育的氛圍及環境對兒童發展的影響極為強大，能否為下一代提供理想的學習環境，絕對是家長們需要深思的一道問題。948Please respect copyright.ＰＥＮＡＮＡ71R22TCfhe
948Please respect copyright.ＰＥＮＡＮＡhxKd1qP425
948Please respect copyright.ＰＥＮＡＮＡ7D4SQGhngj
同樣道理，癌細胞的周遭環境亦為它提供了有利抵禦外來藥物侵襲的能力。948Please respect copyright.ＰＥＮＡＮＡlMUperbilA
要消滅癌細胞的話，必須了解它如何與周遭環境互動，再對其加以入手。948Please respect copyright.ＰＥＮＡＮＡDS3vT7GbM7
948Please respect copyright.ＰＥＮＡＮＡ0lvL5Vf5Kx
（圖2）癌細胞的周遭環境極為複雜，事實上學界不少會以「器官」而非「細胞」來冠稱癌症，皆因它與多款周遭細胞建立了不少互利關係並寄予依賴，而非以單一個體的方式生存。948Please respect copyright.ＰＥＮＡＮＡXMwwlkaekZ
948Please respect copyright.ＰＥＮＡＮＡm2v1s7edwv
948Please respect copyright.ＰＥＮＡＮＡs0R5PHhcms
基於癌細胞與周遭環境互動所涉及的範圍非常之多，本篇將只會粗略講及營養及氧氣這一範疇。948Please respect copyright.ＰＥＮＡＮＡ65VV6YNTM0
948Please respect copyright.ＰＥＮＡＮＡWlsgw2fsjz
（圖3）血管是運送營養及氧氣的主要途徑，基於癌細胞的血管結構並不完整及參差不齊，以及腫瘤過度生長使靠近核心部份的區域遠離血管，腫瘤的某部份區域是經常性處於低氧氣及缺乏營養的狀態。948Please respect copyright.ＰＥＮＡＮＡhAHM2wXn7m
948Please respect copyright.ＰＥＮＡＮＡSDA7cozsza
948Please respect copyright.ＰＥＮＡＮＡbat1k0XQ11
當然，這是實體腫癌才會遇上的情景，血癌或者浮遊在血液循環系統的癌細胞則較少會面對營養或氧氣缺乏的局面。948Please respect copyright.ＰＥＮＡＮＡQ7TmG79r08
948Please respect copyright.ＰＥＮＡＮＡ1Z9BfpoWmd
然而，從右圖可見，距離血管超過60μm的區域已經沒有氧氣能夠抵達，而腫瘤半徑超過100μm基本上是等閒之事，所以很多時候均會把腫瘤的環境定性為低氧狀態(Hypoxia)，或完全缺氧(Anoxia)。948Please respect copyright.ＰＥＮＡＮＡWKIivhC10A
948Please respect copyright.ＰＥＮＡＮＡkiy72fJ3A9
外來的藥物需要經由血管輸送抵達癌細胞才能發揮功用，藥物基乎無法抵達癌細胞與血管距離較遠的區域，導致藥物沒能以有效的濃度抵達腫瘤各處。948Please respect copyright.ＰＥＮＡＮＡN1m7DNcuJG
948Please respect copyright.ＰＥＮＡＮＡiBO9njJGat
而且癌細胞在缺氧缺營養的狀態下，生長速度會有所減慢，這正好避過不少針對快速生長細胞特性的化療藥物追捕。948Please respect copyright.ＰＥＮＡＮＡOyCPQTDUxa
948Please respect copyright.ＰＥＮＡＮＡzTvw944kkd
除藥物外，放射性治療的放射線必需依靠氧氣作為媒體才能傳遞及散播，因此這方法沒能有效根治在低氧環境下的癌細胞區域。948Please respect copyright.ＰＥＮＡＮＡCQz6WH9jjC
948Please respect copyright.ＰＥＮＡＮＡxSfPRUltJI
948Please respect copyright.ＰＥＮＡＮＡaMrWqdO48d
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。948Please respect copyright.ＰＥＮＡＮＡUWLX7GTi2d
948Please respect copyright.ＰＥＮＡＮＡt5KzlqvACD
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc948Please respect copyright.ＰＥＮＡＮＡNYRoU5EgHA
948Please respect copyright.ＰＥＮＡＮＡKNTIbQmNCg
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。948Please respect copyright.ＰＥＮＡＮＡTDwxo63Luw
948Please respect copyright.ＰＥＮＡＮＡPtkYG6TrXH
Link:948Please respect copyright.ＰＥＮＡＮＡFWWLwhre56
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio948Please respect copyright.ＰＥＮＡＮＡsfM7QarB1U
948Please respect copyright.ＰＥＮＡＮＡjbw3YM32iK
948Please respect copyright.ＰＥＮＡＮＡGnDp448OhO
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。948Please respect copyright.ＰＥＮＡＮＡKYGJvl8xO2
948Please respect copyright.ＰＥＮＡＮＡMPymcQayeE
Ref1:https://academic.oup.com/jnci/article/99/19/1441/2544230948Please respect copyright.ＰＥＮＡＮＡFazYtTwf9l

ns216.73.216.190da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章