科普專欄–薯不揀單 - 三十秒科學–脂肪酸對癌細胞的重要性

世界非常殘酷，美味可口的食物很多時候都是高脂高卡路里。965Please respect copyright.ＰＥＮＡＮＡXWsboquNDC
965Please respect copyright.ＰＥＮＡＮＡKvULxxWbfQ
965Please respect copyright.ＰＥＮＡＮＡDI6zewr4FV
如果餐單的卡路里長期是以脂肪為主導的話，又是否會更容易產生癌症呢?965Please respect copyright.ＰＥＮＡＮＡssF2hoxgyf
965Please respect copyright.ＰＥＮＡＮＡLeVaNnl2tp
（圖2）有科學家對此進行研究（Ref1)，餵食老鼠為期7日脂肪佔總卡路里約60%的餐單，然後再透過血管移植人類的口腔癌細胞，其後密切跟進腫瘤的狀況。965Please respect copyright.ＰＥＮＡＮＡyDs0NgBbX3
965Please respect copyright.ＰＥＮＡＮＡWVGjvEsD9g
965Please respect copyright.ＰＥＮＡＮＡW977MSCmKg
如何跟進? 就是用上集所介紹的螢光技術。965Please respect copyright.ＰＥＮＡＮＡj8vFQNb2Tv
965Please respect copyright.ＰＥＮＡＮＡpx6guqAKzd
詳情可見：三十秒科學–透視癌細胞965Please respect copyright.ＰＥＮＡＮＡ8mJMzBm0bG
- 分享自 LIHKG 討論區965Please respect copyright.ＰＥＮＡＮＡbFRm6W2QSS
https://lih.kg/2408323965Please respect copyright.ＰＥＮＡＮＡNr3MmFRLIl
965Please respect copyright.ＰＥＮＡＮＡxvxke8Gvec
965Please respect copyright.ＰＥＮＡＮＡSAIeBEfgzh
（圖3）從圖中可以看得見，進食脂肪主導餐單的老鼠，原生腫瘤的體積不但更為巨大，而且亦有更高機率出現癌細胞轉移的情況。965Please respect copyright.ＰＥＮＡＮＡoIeOBMBCrK
965Please respect copyright.ＰＥＮＡＮＡpgtZJ5ENer
965Please respect copyright.ＰＥＮＡＮＡrrOa9Rvnsh
CD36是輔助細胞吸取脂肪酸的蛋白質，當癌細胞的CD36被除去的時候，莫論餐單是否由脂肪主導，原生腫瘤的體積均沒有顯著大變化，而且亦沒有出現癌細胞轉移的情況。965Please respect copyright.ＰＥＮＡＮＡu2LPBSPJPD
965Please respect copyright.ＰＥＮＡＮＡfBMxxSJpIJ
（圖4）當細胞遇上棕櫚酸約兩日後，細胞的CD36蛋白質數量亦會因而上升。965Please respect copyright.ＰＥＮＡＮＡj7Ht8X3pNX
965Please respect copyright.ＰＥＮＡＮＡQ5vRGCDf7V
965Please respect copyright.ＰＥＮＡＮＡnhF9jdq2l6
從右圖中可以清晰見得到，經過棕櫚酸「調教」過的癌細胞，移植到老鼠後會出現非常明顯的癌細胞轉移過程。965Please respect copyright.ＰＥＮＡＮＡiseoXsjqAR
而當癌細胞的CD36蛋白質被移除後，癌細胞轉移過程亦再沒有發生。965Please respect copyright.ＰＥＮＡＮＡODMxxZH69B
965Please respect copyright.ＰＥＮＡＮＡBT57eShVzH
現時有不少藥物嘗試針對CD36來醫治癌細胞或阻止其進行轉移的程序，但不少藥物均在第二期臨床研究裡頭因為出現副作用或效率未如預期被迫中斷。965Please respect copyright.ＰＥＮＡＮＡVmQtj9fcwD
965Please respect copyright.ＰＥＮＡＮＡ1zWL5Ujgpf
或許需要更多研究理解CD36在細胞的作用或機制，才能設計出輕微副作用的治癌藥物。965Please respect copyright.ＰＥＮＡＮＡkTbtDOKI7m
965Please respect copyright.ＰＥＮＡＮＡRDk8Fwe4zL
965Please respect copyright.ＰＥＮＡＮＡnyzhTDzoMj
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。965Please respect copyright.ＰＥＮＡＮＡxTbptE3Hrs
965Please respect copyright.ＰＥＮＡＮＡr0H9NMWttE
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc965Please respect copyright.ＰＥＮＡＮＡReqbOjQvay
965Please respect copyright.ＰＥＮＡＮＡDze52nJseU
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。965Please respect copyright.ＰＥＮＡＮＡxC9HTuk9G2
965Please respect copyright.ＰＥＮＡＮＡQQxWJ74Qcp
Link:965Please respect copyright.ＰＥＮＡＮＡKOtN8ohGM6
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio965Please respect copyright.ＰＥＮＡＮＡpxgLHedpVW
965Please respect copyright.ＰＥＮＡＮＡ7Ydo1r0FlZ
965Please respect copyright.ＰＥＮＡＮＡMytCkVEn0k
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。965Please respect copyright.ＰＥＮＡＮＡIyZylrtPFi
965Please respect copyright.ＰＥＮＡＮＡVKTTZSw0vk
Ref1:https://pubmed.ncbi.nlm.nih.gov/27974793/965Please respect copyright.ＰＥＮＡＮＡjGKsAKw1VZ

ns216.73.217.1da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章