科普專欄–薯不揀單 - 深入淺出–從深海生物中發掘出抗真菌藥物

真菌感染(Fungi Infection)約引致全球每年約二百萬人的死亡，而現今對抗真菌(Fungi)的藥物類別主要共分為三大類別。621Please respect copyright.ＰＥＮＡＮＡm7YddLt60S
621Please respect copyright.ＰＥＮＡＮＡKlmcWIjNon
621Please respect copyright.ＰＥＮＡＮＡXlWmiFLKT9
（圖2）三大類別的藥物機制雖有不同，但最終目的均是透過破壞真菌的外層結構來抑制其生長。621Please respect copyright.ＰＥＮＡＮＡwHQtcaOGaQ
621Please respect copyright.ＰＥＮＡＮＡaR0NjOZd2c
621Please respect copyright.ＰＥＮＡＮＡ5Dui9gO61y
1.Azole621Please respect copyright.ＰＥＮＡＮＡ7HJGL8kU6R
抑制構成細胞膜的Ergosterol產生621Please respect copyright.ＰＥＮＡＮＡZPeBgNyt5y
2. Polyene621Please respect copyright.ＰＥＮＡＮＡi80QpntEoe
消耗細胞膜的Ergosterol621Please respect copyright.ＰＥＮＡＮＡoetSmBATG9
3. Echinocandins621Please respect copyright.ＰＥＮＡＮＡiNbeOsB3DT
抑制構成細胞外層的糖分組織產生621Please respect copyright.ＰＥＮＡＮＡIYATagzCOP
621Please respect copyright.ＰＥＮＡＮＡKqm8Av3l2N
621Please respect copyright.ＰＥＮＡＮＡM0iT1D82eI
（圖3）然而，現今出現了某一類別的Candida auris，上述三款的藥物均對它無法作出顯著功效。621Please respect copyright.ＰＥＮＡＮＡe9uAQUzQLj
621Please respect copyright.ＰＥＮＡＮＡ1QJm83rO1N
621Please respect copyright.ＰＥＮＡＮＡ8ceO9N1MiN
它能夠透過血液循環系統走進全身各部位，引發感染。621Please respect copyright.ＰＥＮＡＮＡzCmkp3rcmY
621Please respect copyright.ＰＥＮＡＮＡ7rOXg5MFMN
就在2018年，英國急症室病人出現大規模Candida auris的感染，後來證實為共用探熱針所致（Ref1)。621Please respect copyright.ＰＥＮＡＮＡs7mr16NX0H
621Please respect copyright.ＰＥＮＡＮＡxtbzbmn8I4
(圖4）有科學家近日發表文章（Ref2)，在居住在深海生物的微生物中分離出命名為Turbinmicin的天然物質。621Please respect copyright.ＰＥＮＡＮＡ3fULxbsWwG
621Please respect copyright.ＰＥＮＡＮＡ2gwp1Gwlgy
621Please respect copyright.ＰＥＮＡＮＡWVjv8eVOGQ
Turbinmicin能有效抑制不同真菌品種，包括Candida auris。621Please respect copyright.ＰＥＮＡＮＡrjNhRm1qRQ
621Please respect copyright.ＰＥＮＡＮＡe3nywMBgJz
它的機制乃為影響內部的蛋白質運輸，與現今三類抑制外圍結構的機制不同，可能因而能夠擊殺得到抵擋現今三大類藥物的Candida auris。621Please respect copyright.ＰＥＮＡＮＡBKn0nZsBdd
621Please respect copyright.ＰＥＮＡＮＡm0zPKqKHNC
它並不會對人體的紅血球造成傷害，高劑量的使用亦沒有對老鼠做成影響，同時亦能治理Candida auris在老鼠體內所引發的感染。621Please respect copyright.ＰＥＮＡＮＡYMdFk2qRVb
621Please respect copyright.ＰＥＮＡＮＡ5XkDIT8JSi
但會否引起副作用或其他問題，還需要進一步的研究確實後，才能開啟人類試驗。621Please respect copyright.ＰＥＮＡＮＡX9Zc3OF6qm
621Please respect copyright.ＰＥＮＡＮＡAB42H2I99V
621Please respect copyright.ＰＥＮＡＮＡFjsiFB33N1
深海一直是未被深入發掘的領域，這一次找到對抗耐藥真菌曙光，日後可能會繼續有意想不到的驚喜。621Please respect copyright.ＰＥＮＡＮＡKMjZq0Aglw
621Please respect copyright.ＰＥＮＡＮＡTk01CPy86B
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。621Please respect copyright.ＰＥＮＡＮＡDZz6x0Wg8G
621Please respect copyright.ＰＥＮＡＮＡzDrnqXXOrc
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc621Please respect copyright.ＰＥＮＡＮＡ7ft1PzHRd8
621Please respect copyright.ＰＥＮＡＮＡR6frG6nWmP
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。621Please respect copyright.ＰＥＮＡＮＡBQlc78BNHM
621Please respect copyright.ＰＥＮＡＮＡ8vr7szrQv9
Link:621Please respect copyright.ＰＥＮＡＮＡfzJH8S4btf
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio621Please respect copyright.ＰＥＮＡＮＡjOpCFokNWw
621Please respect copyright.ＰＥＮＡＮＡLeNgAjiCZP
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。621Please respect copyright.ＰＥＮＡＮＡnsJWpiS9Sb
621Please respect copyright.ＰＥＮＡＮＡf5oOV971vz
https://www.instagram.com/potatopigtongue/621Please respect copyright.ＰＥＮＡＮＡaRBq2oTMbj
621Please respect copyright.ＰＥＮＡＮＡSPqo1bmLWo
Ref1:https://www.nejm.org/doi/full/10.1056/NEJMc1900112621Please respect copyright.ＰＥＮＡＮＡjP9d3Xb2hP
Ref2:https://science.sciencemag.org/content/370/6519/974621Please respect copyright.ＰＥＮＡＮＡHA5jDjl9y7

ns216.73.216.246da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章