真菌感染(Fungi Infection)約引致全球每年約二百萬人的死亡,而現今對抗真菌(Fungi)的藥物類別主要共分為三大類別。426Please respect copyright.PENANAoiWM5mzTUQ
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(圖2)三大類別的藥物機制雖有不同,但最終目的均是透過破壞真菌的外層結構來抑制其生長。426Please respect copyright.PENANAtAZsMpfnGR
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1.Azole426Please respect copyright.PENANAAM5ys9tO6Y
抑制構成細胞膜的Ergosterol產生426Please respect copyright.PENANAGMunk2Km08
2. Polyene426Please respect copyright.PENANAXO9YYrSczf
消耗細胞膜的Ergosterol426Please respect copyright.PENANAjC7ktSAiVX
3. Echinocandins426Please respect copyright.PENANAp8Z7ufPCTo
抑制構成細胞外層的糖分組織產生426Please respect copyright.PENANAdxzsx35yyr
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(圖3)然而,現今出現了某一類別的Candida auris,上述三款的藥物均對它無法作出顯著功效。426Please respect copyright.PENANAs3Im683fIQ
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它能夠透過血液循環系統走進全身各部位,引發感染。426Please respect copyright.PENANABsp2OQ4LFA
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就在2018年,英國急症室病人出現大規模Candida auris的感染,後來證實為共用探熱針所致(Ref1)。426Please respect copyright.PENANAzqeNg1cnc7
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(圖4)有科學家近日發表文章(Ref2),在居住在深海生物的微生物中分離出命名為Turbinmicin的天然物質。426Please respect copyright.PENANACe2sG9zzhX
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Turbinmicin能有效抑制不同真菌品種,包括Candida auris。426Please respect copyright.PENANAWjWIvgcnDG
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它的機制乃為影響內部的蛋白質運輸,與現今三類抑制外圍結構的機制不同,可能因而能夠擊殺得到抵擋現今三大類藥物的Candida auris。426Please respect copyright.PENANAI8Mfr4AgnA
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它並不會對人體的紅血球造成傷害,高劑量的使用亦沒有對老鼠做成影響,同時亦能治理Candida auris在老鼠體內所引發的感染。426Please respect copyright.PENANAU8EI6kCcGs
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但會否引起副作用或其他問題,還需要進一步的研究確實後,才能開啟人類試驗。426Please respect copyright.PENANApgzeinfppq
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深海一直是未被深入發掘的領域,這一次找到對抗耐藥真菌曙光,日後可能會繼續有意想不到的驚喜。426Please respect copyright.PENANAe6wmAz2h5V
426Please respect copyright.PENANAEaoZRUWYhg
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。426Please respect copyright.PENANAxPdxk96rkG
426Please respect copyright.PENANAmYXJaH6TMn
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc426Please respect copyright.PENANA1o7bjZQWh9
426Please respect copyright.PENANAsUv0EQo01e
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。426Please respect copyright.PENANAkNCDpU2vKm
426Please respect copyright.PENANAwmAg9F5caO
Link:426Please respect copyright.PENANAp022GUfktj
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio426Please respect copyright.PENANA2oiVhkz3Bt
426Please respect copyright.PENANAHkyGhR7tvj
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。426Please respect copyright.PENANAt16J4xLNIB
426Please respect copyright.PENANA6L2tJk3MD3
https://www.instagram.com/potatopigtongue/426Please respect copyright.PENANAEKutAsoD3h
426Please respect copyright.PENANA7eV9K170o2
Ref1:https://www.nejm.org/doi/full/10.1056/NEJMc1900112426Please respect copyright.PENANAErKjDnQRqj
Ref2:https://science.sciencemag.org/content/370/6519/974426Please respect copyright.PENANA9XiPmZKUUm
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科普專欄–薯不揀單
Author:
薯仔聞茱莉
ISSUE #108
深入淺出–從深海生物中發掘出抗真菌藥物
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