科普專欄–薯不揀單 - 深入淺出–癌症藥物研究的奇效個案(1)

要通過癌症藥物臨床研究，其中的一道標準就是藥物有高度效率殺滅癌細胞。517Please respect copyright.ＰＥＮＡＮＡ89qIqmayrK
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追求高效率無可厚非，但以這個例子中，101個病人中，只有1人見效，是否真的代表要放棄這藥呢?517Please respect copyright.ＰＥＮＡＮＡD4yODx8k6o
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（圖2）在一次Phase2臨床研究中，Everolimus藥物未能在大部份病人中見得到成效，唯獨在一名病人中出現奇效。517Please respect copyright.ＰＥＮＡＮＡ5iCCNr3tPx
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圖中紅箭嘴所指的位置為腫瘤所在地。用藥6個月後，腫瘤完全消失，情況一直持續至2年半有多。517Please respect copyright.ＰＥＮＡＮＡdJf44TXk95
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這個情況下，又是否應該放棄這藥物，就這樣以奇蹟二字來解釋此事作罷呢?517Please respect copyright.ＰＥＮＡＮＡG7wYb8AjrF
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（圖3）有科學家死心不惜(Ref1)，致力研究那名病人為何會對此藥作出如此正面的效果。517Please respect copyright.ＰＥＮＡＮＡNtFZvZjUbO
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最後確認原因是那名病人同時在兩道基因NF2及TSC1出現變異，引致該藥物的機制更能有效針對癌細胞。517Please respect copyright.ＰＥＮＡＮＡdxqyJN02yK
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那場臨床研究主要是針對膀胱癌病人，而膀胱癌同時會出現這兩種基因變異的機率非常之低，因此研究結果非常參差。517Please respect copyright.ＰＥＮＡＮＡ7GPBg3FV6m
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但是，倘若將來有其他癌症病人同時擁有這兩道基因變異呢?517Please respect copyright.ＰＥＮＡＮＡxkhpMDZWOF
如果此藥物能有效應付出現這兩道變異基因的癌症，那麼藥物是否還是值得推出市場呢？517Please respect copyright.ＰＥＮＡＮＡnB3u4Hpcnv
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無論如何，此藥最後在2012及2018年被FDA認可，可用作醫療與TSC基因變異有關的症狀。517Please respect copyright.ＰＥＮＡＮＡR5YH9Iy1qu
那份科學家死心不惜的研究是否有作出相關功勞，並沒有真接證據可顯示得到。517Please respect copyright.ＰＥＮＡＮＡ2y283BSUR8
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但這份研究明顯地帶出了一道訊息，就算新藥沒能對大部份的病人見效，亦是值得擺放努力剖析為何會對小部份人見效，分分中可能會有意外的收獲，增進開放藥物的新方向。517Please respect copyright.ＰＥＮＡＮＡ5mcRCj996y
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。517Please respect copyright.ＰＥＮＡＮＡCWL1TAgsvj
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc517Please respect copyright.ＰＥＮＡＮＡJKc10EYXPa
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。517Please respect copyright.ＰＥＮＡＮＡ96h4bz53Ga
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Link:517Please respect copyright.ＰＥＮＡＮＡKkV88k1wvY
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio517Please respect copyright.ＰＥＮＡＮＡ085RXm2dTZ
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。517Please respect copyright.ＰＥＮＡＮＡc2U4qb1XWY
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Ref1:https://pubmed.ncbi.nlm.nih.gov/22923433/

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