科普專欄–薯不揀單 - 深入淺出–從深海生物中發掘出抗真菌藥物

真菌感染(Fungi Infection)約引致全球每年約二百萬人的死亡，而現今對抗真菌(Fungi)的藥物類別主要共分為三大類別。597Please respect copyright.ＰＥＮＡＮＡGWQ7hhDgaU
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（圖2）三大類別的藥物機制雖有不同，但最終目的均是透過破壞真菌的外層結構來抑制其生長。597Please respect copyright.ＰＥＮＡＮＡsPG2qJqETG
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1.Azole597Please respect copyright.ＰＥＮＡＮＡKuv2UtO75L
抑制構成細胞膜的Ergosterol產生597Please respect copyright.ＰＥＮＡＮＡrmDiwPQJgn
2. Polyene597Please respect copyright.ＰＥＮＡＮＡ8clqPbCOBk
消耗細胞膜的Ergosterol597Please respect copyright.ＰＥＮＡＮＡGgGSIYvQrL
3. Echinocandins597Please respect copyright.ＰＥＮＡＮＡvDOv4PKhBQ
抑制構成細胞外層的糖分組織產生597Please respect copyright.ＰＥＮＡＮＡ4G0bDL965z
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（圖3）然而，現今出現了某一類別的Candida auris，上述三款的藥物均對它無法作出顯著功效。597Please respect copyright.ＰＥＮＡＮＡV705T2DitI
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它能夠透過血液循環系統走進全身各部位，引發感染。597Please respect copyright.ＰＥＮＡＮＡcKxJGee8SY
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就在2018年，英國急症室病人出現大規模Candida auris的感染，後來證實為共用探熱針所致（Ref1)。597Please respect copyright.ＰＥＮＡＮＡaCMT7FhBp4
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(圖4）有科學家近日發表文章（Ref2)，在居住在深海生物的微生物中分離出命名為Turbinmicin的天然物質。597Please respect copyright.ＰＥＮＡＮＡuY4hm9eyTb
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Turbinmicin能有效抑制不同真菌品種，包括Candida auris。597Please respect copyright.ＰＥＮＡＮＡzoDDFDvVFN
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它的機制乃為影響內部的蛋白質運輸，與現今三類抑制外圍結構的機制不同，可能因而能夠擊殺得到抵擋現今三大類藥物的Candida auris。597Please respect copyright.ＰＥＮＡＮＡPoU0imp96I
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它並不會對人體的紅血球造成傷害，高劑量的使用亦沒有對老鼠做成影響，同時亦能治理Candida auris在老鼠體內所引發的感染。597Please respect copyright.ＰＥＮＡＮＡ6SWoPAL1JH
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但會否引起副作用或其他問題，還需要進一步的研究確實後，才能開啟人類試驗。597Please respect copyright.ＰＥＮＡＮＡRE0vNlWltC
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深海一直是未被深入發掘的領域，這一次找到對抗耐藥真菌曙光，日後可能會繼續有意想不到的驚喜。597Please respect copyright.ＰＥＮＡＮＡ5yvGUgFlAZ
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。597Please respect copyright.ＰＥＮＡＮＡxnGo3nKV1q
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc597Please respect copyright.ＰＥＮＡＮＡR4kyhogvGM
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。597Please respect copyright.ＰＥＮＡＮＡnfkdseSzV4
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Link:597Please respect copyright.ＰＥＮＡＮＡpgfOS8T1UN
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio597Please respect copyright.ＰＥＮＡＮＡfuXa5ubsNH
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。597Please respect copyright.ＰＥＮＡＮＡN8JbvKAUE0
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Ref1:https://www.nejm.org/doi/full/10.1056/NEJMc1900112597Please respect copyright.ＰＥＮＡＮＡPVo1dgwSR2
Ref2:https://science.sciencemag.org/content/370/6519/974597Please respect copyright.ＰＥＮＡＮＡVwUwlEHeaX

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