科普專欄–薯不揀單 - 深入淺出–利用受精雞蛋作癌細胞研究

癌症研究中，很多時候都會將癌細胞注入在老鼠身內，然後再試驗各種藥物，認證在實驗室細胞中所獲得的結果。597Please respect copyright.ＰＥＮＡＮＡ26McUdiPy3
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除了老鼠、兔、魚、狗、蟲等動物外，受精雞蛋亦是一款常用的實驗模型。597Please respect copyright.ＰＥＮＡＮＡfi7fETvyqX
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（圖2）受精雞蛋中存有氣囊以及充滿血管系統的外膜，提供了一道營養充足的環境。那外膜的名稱為chorioallantoic membrane (CAM) ，因而這款動物模型亦稱之為CAM model。597Please respect copyright.ＰＥＮＡＮＡkh7FD5wxk7
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在受精蛋誕下的第15日前，淋巴系統尚未完善建立，不存在免疫衝突問題，因此適合移植人類癌細胞之用。597Please respect copyright.ＰＥＮＡＮＡt6ZEBkufb2
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同時胚胎痛楚接收系統在第15日前未完整建成，若然能在第15日前完成實驗，道德爭議的問題亦相對減低。597Please respect copyright.ＰＥＮＡＮＡjLISY79i8k
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（圖3）從圖中可見，癌細胞會在血管上形成腫瘤，同時癌細胞（綠色螢光）會透過血管轉移到雞蛋各部份，甚至聚居到胚胎的肺部及腎臟位置。597Please respect copyright.ＰＥＮＡＮＡBfNAlWm6h0
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此方法可同時驗證藥物對於癌細胞繁殖及轉移能力的影響，名副其實的一雞兩味。597Please respect copyright.ＰＥＮＡＮＡtFIkAT3Fwv
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亦有研究嘗試推展把真實病人的癌細胞樣本移植到CAM model，再試用不同藥物在其上，希望藉此能找出一款最為適合醫治該病人的藥物或方法。597Please respect copyright.ＰＥＮＡＮＡ4l55XZM6lG
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。597Please respect copyright.ＰＥＮＡＮＡywiwNQvFCW
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc597Please respect copyright.ＰＥＮＡＮＡhwzwC3Vk6f
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。597Please respect copyright.ＰＥＮＡＮＡD1I0bHy5Ql
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Link:597Please respect copyright.ＰＥＮＡＮＡ1MCmitBnLs
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio597Please respect copyright.ＰＥＮＡＮＡ4AC0ucHZTv
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。597Please respect copyright.ＰＥＮＡＮＡIrPx2xggiC
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Ref1:https://pubmed.ncbi.nlm.nih.gov/23730406/597Please respect copyright.ＰＥＮＡＮＡSZAjqDYRyu
Ref2:https://www.sciencedirect.com/science/article/pii/S0925477316300363597Please respect copyright.ＰＥＮＡＮＡe7mnoUiXMj

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