日照工作的時候，我們腦部的神經細胞會產生與神經退化症狀有關連的β-amyloid (Aβ)。801Please respect copyright.ＰＥＮＡＮＡcmK6CUq1Ow
801Please respect copyright.ＰＥＮＡＮＡpHbT0q8Y7V
801Please respect copyright.ＰＥＮＡＮＡzEASL94D2W
在睡覺尤其是深層睡眠的時候，我們腦部的神經細胞會減少產生β-amyloid (Aβ)。同時間， β-amyloid (Aβ)會從腦脊髓液轉移到血液循環系統的靜脈，離開大腦。801Please respect copyright.ＰＥＮＡＮＡ8qb0AIcIdp
801Please respect copyright.ＰＥＮＡＮＡT030p2u6dK
夜間工作而日照時間睡覺會否達到同樣效果，暫時未有人體確實數據可以證實。801Please respect copyright.ＰＥＮＡＮＡDZcnhtLCMy
801Please respect copyright.ＰＥＮＡＮＡNFxLWtvAHY
801Please respect copyright.ＰＥＮＡＮＡF3LkkuvO4W
801Please respect copyright.ＰＥＮＡＮＡTx0aTnQRKt
（圖2）睡覺時份，位於腦脊髓液(CSF)的β-amyloid (Aβ)透過星狀細胞(astrocyte)的協助，抵達靜脈排出腦外；801Please respect copyright.ＰＥＮＡＮＡihELplBH05
801Please respect copyright.ＰＥＮＡＮＡzCNU9A2OP3
另有研究指出（Ref1)，部份的麻醉藥亦能促成同等效果。801Please respect copyright.ＰＥＮＡＮＡkNe3jyRlm4
801Please respect copyright.ＰＥＮＡＮＡEeNXjQ7xi6
淋巴系統(Lymphatic System）是排除廢物的系統，基於排除Aβ需要透過星狀細胞的幫助，學術界把整套系統命名為Glympathic system，取其Glial Cell(神經膠質細胞）及Lymphatic System（淋巴系統）的結合，雖則整個機制並沒有淋巴系統的參與（Ref5)。801Please respect copyright.ＰＥＮＡＮＡMcphqPwCFj
801Please respect copyright.ＰＥＮＡＮＡqWHH0V2jN3
年老以及神經退化症狀的患者，Glympathic system效率大幅減低，因此引致大量β-amyloid (Aβ)聚積在腦部。而大量Aβ聚積在腦部的話，亦會影響睡眠的質素，形成惡性循環(Ref6)。801Please respect copyright.ＰＥＮＡＮＡsLgGMLubmA
801Please respect copyright.ＰＥＮＡＮＡuYF8g08dL2
對比年輕人士，年老者的腦部Aβ水平平均高出17%。以同等年齡作比較的話，患有神經退化症人士的腦部Aβ水平則比健康人士平均高出31%。801Please respect copyright.ＰＥＮＡＮＡNsfS3J6iLz
801Please respect copyright.ＰＥＮＡＮＡUjzvt5R2TB
801Please respect copyright.ＰＥＮＡＮＡ6NYlmeYxe5
801Please respect copyright.ＰＥＮＡＮＡnPTAxvy7ou
（圖3）為作進一步了解睡覺與腦部Aβ水平的關係，有研究(Ref2)找來20名人士，分別嘗試進行連續31小時不准睡覺以及睡覺9小時兩種環境，繼而量度Aβ水平。801Please respect copyright.ＰＥＮＡＮＡi2B6CYykUn
801Please respect copyright.ＰＥＮＡＮＡcQynQ4Eu9R
兩種測驗環境之間，測試者平均相隔15日分別進行。結果得出，不論性別歲數，通宵一晚平均將會導致5%的Aβ上升。801Please respect copyright.ＰＥＮＡＮＡCafEp7K71H
801Please respect copyright.ＰＥＮＡＮＡ01RDYnGRev
801Please respect copyright.ＰＥＮＡＮＡtQUJmgp5RV
801Please respect copyright.ＰＥＮＡＮＡaUtYS4k5aa
（圖4）另外，他們亦發現睡眠時數與Aβ的移除有著一定程度的正面關係。而另一研究(Ref3)找來了142名試驗者，發現睡眠質素越高的話，Aβ的移除比率亦會越大。801Please respect copyright.ＰＥＮＡＮＡCutzDO9hFJ
801Please respect copyright.ＰＥＮＡＮＡuU6BZd4Rwj
只不過，亦有研究指出睡眠時數少於5小時或多於11的話，認知能力會有衰退傾向，但未知與Aβ是否有關。801Please respect copyright.ＰＥＮＡＮＡuBTx7ootHe
801Please respect copyright.ＰＥＮＡＮＡ2EB6E2rK8Q
801Please respect copyright.ＰＥＮＡＮＡ9GnUy2uWny
長遠而言，通宵會導致Aβ在腦部的聚積，增加患上神經退化症狀的機會，情況許可的話，可免就則免。801Please respect copyright.ＰＥＮＡＮＡTuiUlmzraZ
801Please respect copyright.ＰＥＮＡＮＡ5Ghu8hGdLJ
801Please respect copyright.ＰＥＮＡＮＡoUgJcQFzK2
801Please respect copyright.ＰＥＮＡＮＡKsiANOwjfy
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。801Please respect copyright.ＰＥＮＡＮＡgbxPOVb0lW
801Please respect copyright.ＰＥＮＡＮＡJY1CDpxzZR
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc801Please respect copyright.ＰＥＮＡＮＡKRr749Ro4r
801Please respect copyright.ＰＥＮＡＮＡvd8QS7HdCr
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。801Please respect copyright.ＰＥＮＡＮＡrA756SwsJF
801Please respect copyright.ＰＥＮＡＮＡCqTfkEOHw3
Link:801Please respect copyright.ＰＥＮＡＮＡxCr0dYfJTO
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio801Please respect copyright.ＰＥＮＡＮＡyLoO04iPdv
801Please respect copyright.ＰＥＮＡＮＡ80veGawVds
801Please respect copyright.ＰＥＮＡＮＡMrkp0BxTgR
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。801Please respect copyright.ＰＥＮＡＮＡot7OeC7HHH
801Please respect copyright.ＰＥＮＡＮＡFSrWzJaU9w
Ref1:https://advances.sciencemag.org/content/5/2/eaav5447801Please respect copyright.ＰＥＮＡＮＡHxWCuM3Ci2
Ref2:https://www.pnas.org/content/115/17/4483801Please respect copyright.ＰＥＮＡＮＡNyRifDp4LN
Ref3:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676720/801Please respect copyright.ＰＥＮＡＮＡNSk68LE129
Ref4:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/801Please respect copyright.ＰＥＮＡＮＡh6qTM2djzo
Ref5:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/801Please respect copyright.ＰＥＮＡＮＡjyf3d9hkPh
Ref6:https://www.nature.com/articles/nrneurol.2013.269#ref-CR13​​​​​​​8964 copyright protection797ＰＥＮＡＮＡ2fvYtAlqtL 維尼

216.73.216.228