現今科技發達,藥物大多數也能夠在實驗室或藥廠裡利用化學物合成出來。397Please respect copyright.PENANAp9Id8b8yve
397Please respect copyright.PENANAHFJtNB5W2q
但若果藥物主要成份的結構實在是太過複雜的話,有時候利用人工合成的方法製造只會吃力不討好,不符合經濟效益。397Please respect copyright.PENANAWwPhZ4ErId
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就以治療神經肌肉問題等疾病為例的Tropane alkaloids(TAs),主要情況下均是會從特定品種的植物裡頭提取出來;397Please respect copyright.PENANA26hqnzl5az
397Please respect copyright.PENANA3PXQseFraR
隸屬TAs類別的hyoscyamine及scopolamine可以與acetylcholine receptor結合,更有著解除俄國神經毒素Novichok的能力。397Please respect copyright.PENANA49zLvLAkDi
397Please respect copyright.PENANAlWxQK2qFPf
俄國神經毒素Novichok延伸閱讀:https://www.penana.com/article/477009397Please respect copyright.PENANAKubVHvwzkp
397Please respect copyright.PENANAdl99uCTBru
(圖2)科學家一直致力研究增強培植產生TAs植物的方法,但人口增長快速,相關藥物供不應求的問題開始湧現。397Please respect copyright.PENANAobJn4qWNbz
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再加上植物佔據大量空間及資源,而且生長需時,還有害蟲侵蝕植物導致產量下降各種問題需要關注,長遠來說顯然需要另一種手段製作藥物。397Please respect copyright.PENANAZGwOw4QP0y
397Please respect copyright.PENANAzyHhjHO6d5
(圖3)近日,有科學家發表文章(Ref1),利用生長快、易打理的酵母(yeast)來解決這問題。397Please respect copyright.PENANAyOWpKUZGFh
397Please respect copyright.PENANAckNtg5HcjI
他們利用CRISPR基因編輯技術,將26種來自細菌及植物的基因(其中一種更是燕麥的基因)加進酵母裡頭,強迫酵母利用葡萄糖及氨基酸轉化成為有用的TAs。397Please respect copyright.PENANAzGzNb2URmm
397Please respect copyright.PENANAQcIIpTDyKM
397Please respect copyright.PENANAp87H1QEwfr
CRISPR基因編輯技術延伸閱讀:https://www.penana.com/article/465369397Please respect copyright.PENANATkBHEQoplz
397Please respect copyright.PENANAKke9nzGoqC
過程中他們更分門別類將相應的酵素安放在酵母各個位置,以及刪走一些礙事的基因,務求令到酵母一心一意為製作藥物為主。397Please respect copyright.PENANAjC5sKFdfy7
397Please respect copyright.PENANATePRniBlNZ
暫時他們做到的產量為每一公升酵母能夠生產出30-80 μg TAs,有望在1-2年後提升至每升5g,踏進真實市場裡頭運作。397Please respect copyright.PENANAZlVRrVk1os
397Please respect copyright.PENANAhqcFDoaSwQ
(1g=1000mg,1mg=1000 μg)397Please respect copyright.PENANAXUAOV0K4oL
397Please respect copyright.PENANA7m0CX4RbpF
397Please respect copyright.PENANAz5xfYskZGo
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。397Please respect copyright.PENANAHIrQeuS7dU
397Please respect copyright.PENANAs5xytrnUa1
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc397Please respect copyright.PENANAlZ6eDdISEx
397Please respect copyright.PENANARrVcoSSk8f
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。397Please respect copyright.PENANAFgyOli6qoY
397Please respect copyright.PENANAOzGZPNzs53
Link:397Please respect copyright.PENANAOMJBqZkhAC
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio397Please respect copyright.PENANAgactlBdUrJ
397Please respect copyright.PENANAM5BOKYPUzG
397Please respect copyright.PENANAh3eLEwpGRr
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。397Please respect copyright.PENANACF1nnWaWo1
397Please respect copyright.PENANA3W2izQFmkZ
Ref1:https://www.nature.com/articles/s41586-020-2650-9397Please respect copyright.PENANAJOUL2SNpmB
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科普專欄–薯不揀單
Author:
薯仔聞茱莉
ISSUE #47
深入淺出–改造酵母以作製藥用途
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