科普專欄–薯不揀單 - 三十秒科學–脂肪酸對癌細胞的重要性

世界非常殘酷，美味可口的食物很多時候都是高脂高卡路里。965Please respect copyright.ＰＥＮＡＮＡaj1w8E2958
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如果餐單的卡路里長期是以脂肪為主導的話，又是否會更容易產生癌症呢?965Please respect copyright.ＰＥＮＡＮＡ6zfVyOnddw
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（圖2）有科學家對此進行研究（Ref1)，餵食老鼠為期7日脂肪佔總卡路里約60%的餐單，然後再透過血管移植人類的口腔癌細胞，其後密切跟進腫瘤的狀況。965Please respect copyright.ＰＥＮＡＮＡT5lR2iAKaq
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如何跟進? 就是用上集所介紹的螢光技術。965Please respect copyright.ＰＥＮＡＮＡiyu3kALrmy
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詳情可見：三十秒科學–透視癌細胞965Please respect copyright.ＰＥＮＡＮＡufIcuhcu3a
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（圖3）從圖中可以看得見，進食脂肪主導餐單的老鼠，原生腫瘤的體積不但更為巨大，而且亦有更高機率出現癌細胞轉移的情況。965Please respect copyright.ＰＥＮＡＮＡAbPYO3snJ7
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CD36是輔助細胞吸取脂肪酸的蛋白質，當癌細胞的CD36被除去的時候，莫論餐單是否由脂肪主導，原生腫瘤的體積均沒有顯著大變化，而且亦沒有出現癌細胞轉移的情況。965Please respect copyright.ＰＥＮＡＮＡ5LkZtC8HHn
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（圖4）當細胞遇上棕櫚酸約兩日後，細胞的CD36蛋白質數量亦會因而上升。965Please respect copyright.ＰＥＮＡＮＡnkp0dEFURH
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從右圖中可以清晰見得到，經過棕櫚酸「調教」過的癌細胞，移植到老鼠後會出現非常明顯的癌細胞轉移過程。965Please respect copyright.ＰＥＮＡＮＡ8ZOrtuVXvC
而當癌細胞的CD36蛋白質被移除後，癌細胞轉移過程亦再沒有發生。965Please respect copyright.ＰＥＮＡＮＡJktxl4ikSB
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現時有不少藥物嘗試針對CD36來醫治癌細胞或阻止其進行轉移的程序，但不少藥物均在第二期臨床研究裡頭因為出現副作用或效率未如預期被迫中斷。965Please respect copyright.ＰＥＮＡＮＡMGVD9FCbfQ
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或許需要更多研究理解CD36在細胞的作用或機制，才能設計出輕微副作用的治癌藥物。965Please respect copyright.ＰＥＮＡＮＡQILVmscLLX
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。965Please respect copyright.ＰＥＮＡＮＡKKsyWNex8o
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。965Please respect copyright.ＰＥＮＡＮＡ334OXz2fIG
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio965Please respect copyright.ＰＥＮＡＮＡSXvbegNT2n
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。965Please respect copyright.ＰＥＮＡＮＡ2drN5L2i8O
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Ref1:https://pubmed.ncbi.nlm.nih.gov/27974793/965Please respect copyright.ＰＥＮＡＮＡuviVXTiots

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