科普專欄–薯不揀單 - 三十秒科學–脂肪酸對癌細胞的重要性

世界非常殘酷，美味可口的食物很多時候都是高脂高卡路里。916Please respect copyright.ＰＥＮＡＮＡkDDmLTpUGV
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如果餐單的卡路里長期是以脂肪為主導的話，又是否會更容易產生癌症呢?916Please respect copyright.ＰＥＮＡＮＡJmQT7alucr
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（圖2）有科學家對此進行研究（Ref1)，餵食老鼠為期7日脂肪佔總卡路里約60%的餐單，然後再透過血管移植人類的口腔癌細胞，其後密切跟進腫瘤的狀況。916Please respect copyright.ＰＥＮＡＮＡ1huI6ov1m3
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如何跟進? 就是用上集所介紹的螢光技術。916Please respect copyright.ＰＥＮＡＮＡwtIyOtn5Yh
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詳情可見：三十秒科學–透視癌細胞916Please respect copyright.ＰＥＮＡＮＡs3PAKMG5R1
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（圖3）從圖中可以看得見，進食脂肪主導餐單的老鼠，原生腫瘤的體積不但更為巨大，而且亦有更高機率出現癌細胞轉移的情況。916Please respect copyright.ＰＥＮＡＮＡxOiu1vCjiM
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CD36是輔助細胞吸取脂肪酸的蛋白質，當癌細胞的CD36被除去的時候，莫論餐單是否由脂肪主導，原生腫瘤的體積均沒有顯著大變化，而且亦沒有出現癌細胞轉移的情況。916Please respect copyright.ＰＥＮＡＮＡwpzDYjIkFX
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（圖4）當細胞遇上棕櫚酸約兩日後，細胞的CD36蛋白質數量亦會因而上升。916Please respect copyright.ＰＥＮＡＮＡ09534jOlhB
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從右圖中可以清晰見得到，經過棕櫚酸「調教」過的癌細胞，移植到老鼠後會出現非常明顯的癌細胞轉移過程。916Please respect copyright.ＰＥＮＡＮＡsjNWxakquw
而當癌細胞的CD36蛋白質被移除後，癌細胞轉移過程亦再沒有發生。916Please respect copyright.ＰＥＮＡＮＡx6ZqsuGo1U
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現時有不少藥物嘗試針對CD36來醫治癌細胞或阻止其進行轉移的程序，但不少藥物均在第二期臨床研究裡頭因為出現副作用或效率未如預期被迫中斷。916Please respect copyright.ＰＥＮＡＮＡosfxg3QYri
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或許需要更多研究理解CD36在細胞的作用或機制，才能設計出輕微副作用的治癌藥物。916Please respect copyright.ＰＥＮＡＮＡ56URfhqYRH
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。916Please respect copyright.ＰＥＮＡＮＡWbBGPoZs5X
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc916Please respect copyright.ＰＥＮＡＮＡBM1uDqUADF
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio916Please respect copyright.ＰＥＮＡＮＡICUk6s0nO2
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。916Please respect copyright.ＰＥＮＡＮＡzdDxaSwLfE
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Ref1:https://pubmed.ncbi.nlm.nih.gov/27974793/916Please respect copyright.ＰＥＮＡＮＡ4fKfisncIC

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