科普專欄–薯不揀單 - 深入淺出–從深海生物中發掘出抗真菌藥物

真菌感染(Fungi Infection)約引致全球每年約二百萬人的死亡，而現今對抗真菌(Fungi)的藥物類別主要共分為三大類別。596Please respect copyright.ＰＥＮＡＮＡRwA3Q2vGXq
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（圖2）三大類別的藥物機制雖有不同，但最終目的均是透過破壞真菌的外層結構來抑制其生長。596Please respect copyright.ＰＥＮＡＮＡwW86sIwu7G
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1.Azole596Please respect copyright.ＰＥＮＡＮＡmmuwb3denf
抑制構成細胞膜的Ergosterol產生596Please respect copyright.ＰＥＮＡＮＡVTUbdMYds1
2. Polyene596Please respect copyright.ＰＥＮＡＮＡj8uoJDQK0N
消耗細胞膜的Ergosterol596Please respect copyright.ＰＥＮＡＮＡZr9KQiDq66
3. Echinocandins596Please respect copyright.ＰＥＮＡＮＡELWK2eVXHq
抑制構成細胞外層的糖分組織產生596Please respect copyright.ＰＥＮＡＮＡVx8j1sLNLE
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（圖3）然而，現今出現了某一類別的Candida auris，上述三款的藥物均對它無法作出顯著功效。596Please respect copyright.ＰＥＮＡＮＡRXUpQB75S8
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它能夠透過血液循環系統走進全身各部位，引發感染。596Please respect copyright.ＰＥＮＡＮＡtAhaKpZtb4
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就在2018年，英國急症室病人出現大規模Candida auris的感染，後來證實為共用探熱針所致（Ref1)。596Please respect copyright.ＰＥＮＡＮＡj10Ip022Ev
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(圖4）有科學家近日發表文章（Ref2)，在居住在深海生物的微生物中分離出命名為Turbinmicin的天然物質。596Please respect copyright.ＰＥＮＡＮＡNSEiAYiQMk
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Turbinmicin能有效抑制不同真菌品種，包括Candida auris。596Please respect copyright.ＰＥＮＡＮＡbYVm2FCCh2
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它的機制乃為影響內部的蛋白質運輸，與現今三類抑制外圍結構的機制不同，可能因而能夠擊殺得到抵擋現今三大類藥物的Candida auris。596Please respect copyright.ＰＥＮＡＮＡIMOA50Pibm
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它並不會對人體的紅血球造成傷害，高劑量的使用亦沒有對老鼠做成影響，同時亦能治理Candida auris在老鼠體內所引發的感染。596Please respect copyright.ＰＥＮＡＮＡefVx7uHyhJ
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但會否引起副作用或其他問題，還需要進一步的研究確實後，才能開啟人類試驗。596Please respect copyright.ＰＥＮＡＮＡcuXWpBPf1a
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深海一直是未被深入發掘的領域，這一次找到對抗耐藥真菌曙光，日後可能會繼續有意想不到的驚喜。596Please respect copyright.ＰＥＮＡＮＡ6dFpFxWuAa
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。596Please respect copyright.ＰＥＮＡＮＡY7He0y4r1T
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc596Please respect copyright.ＰＥＮＡＮＡEqeBF8C2x2
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。596Please respect copyright.ＰＥＮＡＮＡO3DVYIPpN7
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Link:596Please respect copyright.ＰＥＮＡＮＡbqmhVQvRDE
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio596Please respect copyright.ＰＥＮＡＮＡeGmecmNllA
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。596Please respect copyright.ＰＥＮＡＮＡtzgpLaNYSX
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Ref1:https://www.nejm.org/doi/full/10.1056/NEJMc1900112596Please respect copyright.ＰＥＮＡＮＡgDPJnNy7hl
Ref2:https://science.sciencemag.org/content/370/6519/974596Please respect copyright.ＰＥＮＡＮＡt0MXoFZtjY

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