現今科技發達,藥物大多數也能夠在實驗室或藥廠裡利用化學物合成出來。637Please respect copyright.PENANANZKmOCQSqg
637Please respect copyright.PENANAHuFfTRPodb
但若果藥物主要成份的結構實在是太過複雜的話,有時候利用人工合成的方法製造只會吃力不討好,不符合經濟效益。637Please respect copyright.PENANAP7ogSQT1ey637Please respect copyright.PENANAXnA1LxDneL
637Please respect copyright.PENANAYD1ERKpI0h
就以治療神經肌肉問題等疾病為例的Tropane alkaloids(TAs),主要情況下均是會從特定品種的植物裡頭提取出來;637Please respect copyright.PENANAyN3xY3lKle
637Please respect copyright.PENANAoAkLHqyIqi
隸屬TAs類別的hyoscyamine及scopolamine可以與acetylcholine receptor結合,更有著解除俄國神經毒素Novichok的能力。637Please respect copyright.PENANAlE7l3h9dBD
637Please respect copyright.PENANA0b3OfuFJ3e
俄國神經毒素Novichok延伸閱讀:https://www.penana.com/article/477009637Please respect copyright.PENANASNmfFkOxVT
637Please respect copyright.PENANAGWRZs8NiFf
(圖2)科學家一直致力研究增強培植產生TAs植物的方法,但人口增長快速,相關藥物供不應求的問題開始湧現。637Please respect copyright.PENANAnLumBNS5Cs637Please respect copyright.PENANAOFo6YCwKGZ
637Please respect copyright.PENANAzDVeAQaWZF
再加上植物佔據大量空間及資源,而且生長需時,還有害蟲侵蝕植物導致產量下降各種問題需要關注,長遠來說顯然需要另一種手段製作藥物。637Please respect copyright.PENANActg8xEQ6YT
637Please respect copyright.PENANAkzfgU6TtAF
(圖3)近日,有科學家發表文章(Ref1),利用生長快、易打理的酵母(yeast)來解決這問題。637Please respect copyright.PENANAugNdnUkh35
637Please respect copyright.PENANAMO5FvySRcm
他們利用CRISPR基因編輯技術,將26種來自細菌及植物的基因(其中一種更是燕麥的基因)加進酵母裡頭,強迫酵母利用葡萄糖及氨基酸轉化成為有用的TAs。637Please respect copyright.PENANAvUzwiPL35p637Please respect copyright.PENANACXeEK7pR7I
637Please respect copyright.PENANA4udZMgoZrn
CRISPR基因編輯技術延伸閱讀:https://www.penana.com/article/465369637Please respect copyright.PENANAjpd9nf2Pcu
637Please respect copyright.PENANAnULRkaIZtj
過程中他們更分門別類將相應的酵素安放在酵母各個位置,以及刪走一些礙事的基因,務求令到酵母一心一意為製作藥物為主。637Please respect copyright.PENANABSoT9gvZfO
637Please respect copyright.PENANAsbeUNRbVMv
暫時他們做到的產量為每一公升酵母能夠生產出30-80 μg TAs,有望在1-2年後提升至每升5g,踏進真實市場裡頭運作。637Please respect copyright.PENANAxoo50405e7
637Please respect copyright.PENANAYHEQjgZ9MY
(1g=1000mg,1mg=1000 μg)637Please respect copyright.PENANAgBUqZ4YiiV
637Please respect copyright.PENANAIwC6CUKTJr
637Please respect copyright.PENANAOB550a8rG0
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。637Please respect copyright.PENANAzoSdgvQtqE
637Please respect copyright.PENANAsu6u167VAg
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc637Please respect copyright.PENANAqBDaVBCokx
637Please respect copyright.PENANAtbbkAzEFIE
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。637Please respect copyright.PENANAclA5TkdF9H
637Please respect copyright.PENANAJp6DzZqk8T
Link:637Please respect copyright.PENANAqMzfQ9VFaM
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio637Please respect copyright.PENANAIRX43Xmf1r
637Please respect copyright.PENANA4B4dHryvR5
637Please respect copyright.PENANAtGBEAWXQ5E
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。637Please respect copyright.PENANA95gUq3QVCC
637Please respect copyright.PENANAg0W4mPkIye
Ref1:https://www.nature.com/articles/s41586-020-2650-9637Please respect copyright.PENANAOe04ZeQrBh
arrow_back
科普專欄–薯不揀單
more_vert
-
info_outline 資料
-
toc 目錄
-
share 分享
-
format_color_text 介面設置
-
exposure_plus_1 推薦
-
打賞
-
report_problem 檢舉
-
account_circle 登入
X
科普專欄–薯不揀單
作者:
薯仔聞茱莉

篇 #47
深入淺出–改造酵母以作製藥用途
喜歡 2
閱讀 633
書籤 150
campaign
催更 0
打賞

按此加載下一章
X
每次催更後,作者都會收到通知!
smartphone100 → 催更
×
寫下你喜歡這個故事的地方
×
對此喜歡的人