科普專欄–薯不揀單 - 深入淺出–改造酵母以作製藥用途

現今科技發達，藥物大多數也能夠在實驗室或藥廠裡利用化學物合成出來。578Please respect copyright.ＰＥＮＡＮＡ0DHAJvbG61
578Please respect copyright.ＰＥＮＡＮＡ9M73ME2BjY
但若果藥物主要成份的結構實在是太過複雜的話，有時候利用人工合成的方法製造只會吃力不討好，不符合經濟效益。578Please respect copyright.ＰＥＮＡＮＡobOagF08rz
578Please respect copyright.ＰＥＮＡＮＡRursNgv0PM
578Please respect copyright.ＰＥＮＡＮＡDHX72Sgi38
就以治療神經肌肉問題等疾病為例的Tropane alkaloids(TAs)，主要情況下均是會從特定品種的植物裡頭提取出來;578Please respect copyright.ＰＥＮＡＮＡMOh9zRWxBR
578Please respect copyright.ＰＥＮＡＮＡaiZ2YUNZtD
隸屬TAs類別的hyoscyamine及scopolamine可以與acetylcholine receptor結合，更有著解除俄國神經毒素Novichok的能力。578Please respect copyright.ＰＥＮＡＮＡP56BFKE7Mn
578Please respect copyright.ＰＥＮＡＮＡZ3FzlrX6na
俄國神經毒素Novichok延伸閱讀：https://www.penana.com/article/477009578Please respect copyright.ＰＥＮＡＮＡpuSY4hnyct
578Please respect copyright.ＰＥＮＡＮＡFGjUzr2OZq
（圖2）科學家一直致力研究增強培植產生TAs植物的方法，但人口增長快速，相關藥物供不應求的問題開始湧現。578Please respect copyright.ＰＥＮＡＮＡnTcJ7dYCz0
578Please respect copyright.ＰＥＮＡＮＡjiai56t37a
578Please respect copyright.ＰＥＮＡＮＡ78FQZDo2xf
再加上植物佔據大量空間及資源，而且生長需時，還有害蟲侵蝕植物導致產量下降各種問題需要關注，長遠來說顯然需要另一種手段製作藥物。578Please respect copyright.ＰＥＮＡＮＡQRfGejrIgs
578Please respect copyright.ＰＥＮＡＮＡw0OYzZWF41
（圖3）近日，有科學家發表文章（Ref1)，利用生長快、易打理的酵母(yeast)來解決這問題。578Please respect copyright.ＰＥＮＡＮＡZf93cSVD36
578Please respect copyright.ＰＥＮＡＮＡwiB1wqXEfH
他們利用CRISPR基因編輯技術，將26種來自細菌及植物的基因（其中一種更是燕麥的基因）加進酵母裡頭，強迫酵母利用葡萄糖及氨基酸轉化成為有用的TAs。578Please respect copyright.ＰＥＮＡＮＡNWJxipWnin
578Please respect copyright.ＰＥＮＡＮＡEwaoCYPM7a
578Please respect copyright.ＰＥＮＡＮＡzhOtzP3QTP
CRISPR基因編輯技術延伸閱讀：https://www.penana.com/article/465369578Please respect copyright.ＰＥＮＡＮＡ0o2Y8yJPgk
578Please respect copyright.ＰＥＮＡＮＡdGZNlewcRO
過程中他們更分門別類將相應的酵素安放在酵母各個位置，以及刪走一些礙事的基因，務求令到酵母一心一意為製作藥物為主。578Please respect copyright.ＰＥＮＡＮＡdgGFjlBHhc
578Please respect copyright.ＰＥＮＡＮＡy9sTpmngZe
暫時他們做到的產量為每一公升酵母能夠生產出30-80 μg TAs，有望在1-2年後提升至每升5g，踏進真實市場裡頭運作。578Please respect copyright.ＰＥＮＡＮＡPOND13QdTM
578Please respect copyright.ＰＥＮＡＮＡhlevoEKdS2
（1g=1000mg，1mg=1000 μg)578Please respect copyright.ＰＥＮＡＮＡCNSN8HD46y
578Please respect copyright.ＰＥＮＡＮＡLHOTXC6Z0s
578Please respect copyright.ＰＥＮＡＮＡjLAsQ55Ctw
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。578Please respect copyright.ＰＥＮＡＮＡHZW3CqHL3H
578Please respect copyright.ＰＥＮＡＮＡ6TdP2661U3
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc578Please respect copyright.ＰＥＮＡＮＡCkVaYCtQIQ
578Please respect copyright.ＰＥＮＡＮＡhPUlXeriRZ
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。578Please respect copyright.ＰＥＮＡＮＡNW24O4OLeu
578Please respect copyright.ＰＥＮＡＮＡpVPIBHKIr9
Link:578Please respect copyright.ＰＥＮＡＮＡoV5fB7HVAh
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio578Please respect copyright.ＰＥＮＡＮＡ2MMwRolbqH
578Please respect copyright.ＰＥＮＡＮＡStZEgOy4HW
578Please respect copyright.ＰＥＮＡＮＡPgQapa6lB0
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。578Please respect copyright.ＰＥＮＡＮＡvRRcKm5OTR
578Please respect copyright.ＰＥＮＡＮＡxNIxBLwOnC
Ref1:https://www.nature.com/articles/s41586-020-2650-9578Please respect copyright.ＰＥＮＡＮＡXEEeBF5MeT

ns18.190.207.156da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章