現今科技發達,藥物大多數也能夠在實驗室或藥廠裡利用化學物合成出來。635Please respect copyright.PENANAXNlU90ObqL
635Please respect copyright.PENANA0JKrzemEQJ
但若果藥物主要成份的結構實在是太過複雜的話,有時候利用人工合成的方法製造只會吃力不討好,不符合經濟效益。635Please respect copyright.PENANAavN9pgJCQT635Please respect copyright.PENANA7CFcWy8Zf2
635Please respect copyright.PENANAOv2PYuYAzo
就以治療神經肌肉問題等疾病為例的Tropane alkaloids(TAs),主要情況下均是會從特定品種的植物裡頭提取出來;635Please respect copyright.PENANAqMZyx8xyBQ
635Please respect copyright.PENANARb4N5haVTb
隸屬TAs類別的hyoscyamine及scopolamine可以與acetylcholine receptor結合,更有著解除俄國神經毒素Novichok的能力。635Please respect copyright.PENANAZKmuoLIOrp
635Please respect copyright.PENANAljw0RozsP4
俄國神經毒素Novichok延伸閱讀:https://www.penana.com/article/477009635Please respect copyright.PENANAN1DInpqZR6
635Please respect copyright.PENANA2HPRCcVKIK
(圖2)科學家一直致力研究增強培植產生TAs植物的方法,但人口增長快速,相關藥物供不應求的問題開始湧現。635Please respect copyright.PENANAVLeNdkCxdk635Please respect copyright.PENANAF5CUHjRKcR
635Please respect copyright.PENANADoHiuncCFf
再加上植物佔據大量空間及資源,而且生長需時,還有害蟲侵蝕植物導致產量下降各種問題需要關注,長遠來說顯然需要另一種手段製作藥物。635Please respect copyright.PENANABtAaRhQz1o
635Please respect copyright.PENANARKHWQGA8MX
(圖3)近日,有科學家發表文章(Ref1),利用生長快、易打理的酵母(yeast)來解決這問題。635Please respect copyright.PENANAfLtSNF33NY
635Please respect copyright.PENANAze4IRRVCjt
他們利用CRISPR基因編輯技術,將26種來自細菌及植物的基因(其中一種更是燕麥的基因)加進酵母裡頭,強迫酵母利用葡萄糖及氨基酸轉化成為有用的TAs。635Please respect copyright.PENANAXphjzLeE7E635Please respect copyright.PENANAAdVQAoahVi
635Please respect copyright.PENANANxVg0xqyAy
CRISPR基因編輯技術延伸閱讀:https://www.penana.com/article/465369635Please respect copyright.PENANANylRcabMky
635Please respect copyright.PENANAjpg7W4BM76
過程中他們更分門別類將相應的酵素安放在酵母各個位置,以及刪走一些礙事的基因,務求令到酵母一心一意為製作藥物為主。635Please respect copyright.PENANAoceDeFwSIc
635Please respect copyright.PENANAEfWpEKH945
暫時他們做到的產量為每一公升酵母能夠生產出30-80 μg TAs,有望在1-2年後提升至每升5g,踏進真實市場裡頭運作。635Please respect copyright.PENANAiqhjWOyCQD
635Please respect copyright.PENANA9rrpPLieYn
(1g=1000mg,1mg=1000 μg)635Please respect copyright.PENANACq5lQjSIFP
635Please respect copyright.PENANA8HrHXHDgnT
635Please respect copyright.PENANAGasZOTMR2i
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。635Please respect copyright.PENANAdIo3ujFXw5
635Please respect copyright.PENANAFczJBvpoDi
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc635Please respect copyright.PENANARE0YopwAeL
635Please respect copyright.PENANA1D3YpW3v0x
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。635Please respect copyright.PENANASqihrT651M
635Please respect copyright.PENANASzua5wZsnt
Link:635Please respect copyright.PENANA2oNanaau2B
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio635Please respect copyright.PENANAliLuM8hPrV
635Please respect copyright.PENANASDyoxC1inJ
635Please respect copyright.PENANAa59OPauHpT
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。635Please respect copyright.PENANAlOVpBupkGd
635Please respect copyright.PENANAXDXa7TnPK3
Ref1:https://www.nature.com/articles/s41586-020-2650-9635Please respect copyright.PENANAAOQab8uF1U
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科普專欄–薯不揀單
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薯仔聞茱莉

篇 #47
深入淺出–改造酵母以作製藥用途
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