科普專欄–薯不揀單 - 深入淺出–從深海生物中發掘出抗真菌藥物

真菌感染(Fungi Infection)約引致全球每年約二百萬人的死亡，而現今對抗真菌(Fungi)的藥物類別主要共分為三大類別。623Please respect copyright.ＰＥＮＡＮＡWTDf7idqfP
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（圖2）三大類別的藥物機制雖有不同，但最終目的均是透過破壞真菌的外層結構來抑制其生長。623Please respect copyright.ＰＥＮＡＮＡ2yFaXCBVje
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1.Azole623Please respect copyright.ＰＥＮＡＮＡzmPMZyCMzG
抑制構成細胞膜的Ergosterol產生623Please respect copyright.ＰＥＮＡＮＡiQ265WjAs3
2. Polyene623Please respect copyright.ＰＥＮＡＮＡpyrRl70gJA
消耗細胞膜的Ergosterol623Please respect copyright.ＰＥＮＡＮＡ6srIlQI9f6
3. Echinocandins623Please respect copyright.ＰＥＮＡＮＡ7hLR2iBb0f
抑制構成細胞外層的糖分組織產生623Please respect copyright.ＰＥＮＡＮＡ1tZ4lreOqB
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（圖3）然而，現今出現了某一類別的Candida auris，上述三款的藥物均對它無法作出顯著功效。623Please respect copyright.ＰＥＮＡＮＡQQkYNaotaP
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它能夠透過血液循環系統走進全身各部位，引發感染。623Please respect copyright.ＰＥＮＡＮＡjluhjRdSdP
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就在2018年，英國急症室病人出現大規模Candida auris的感染，後來證實為共用探熱針所致（Ref1)。623Please respect copyright.ＰＥＮＡＮＡSfZe9fVhkt
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(圖4）有科學家近日發表文章（Ref2)，在居住在深海生物的微生物中分離出命名為Turbinmicin的天然物質。623Please respect copyright.ＰＥＮＡＮＡBNKfjWp5Xp
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Turbinmicin能有效抑制不同真菌品種，包括Candida auris。623Please respect copyright.ＰＥＮＡＮＡd39WHkfmYW
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它的機制乃為影響內部的蛋白質運輸，與現今三類抑制外圍結構的機制不同，可能因而能夠擊殺得到抵擋現今三大類藥物的Candida auris。623Please respect copyright.ＰＥＮＡＮＡPQD4tYuUeW
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它並不會對人體的紅血球造成傷害，高劑量的使用亦沒有對老鼠做成影響，同時亦能治理Candida auris在老鼠體內所引發的感染。623Please respect copyright.ＰＥＮＡＮＡ2yzUE8cBvb
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但會否引起副作用或其他問題，還需要進一步的研究確實後，才能開啟人類試驗。623Please respect copyright.ＰＥＮＡＮＡgHCiRub301
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深海一直是未被深入發掘的領域，這一次找到對抗耐藥真菌曙光，日後可能會繼續有意想不到的驚喜。623Please respect copyright.ＰＥＮＡＮＡpb8baNTF2B
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。623Please respect copyright.ＰＥＮＡＮＡijByLoc3lv
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc623Please respect copyright.ＰＥＮＡＮＡBqGgnzlN9y
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。623Please respect copyright.ＰＥＮＡＮＡIsUEX8W68K
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Link:623Please respect copyright.ＰＥＮＡＮＡGag0rdSn62
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio623Please respect copyright.ＰＥＮＡＮＡ7ZeV7WNNJ0
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。623Please respect copyright.ＰＥＮＡＮＡVS4AAFFvcy
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Ref1:https://www.nejm.org/doi/full/10.1056/NEJMc1900112623Please respect copyright.ＰＥＮＡＮＡiCSTnxCh1U
Ref2:https://science.sciencemag.org/content/370/6519/974623Please respect copyright.ＰＥＮＡＮＡe0Y42xZzeS

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