真菌感染(Fungi Infection)約引致全球每年約二百萬人的死亡,而現今對抗真菌(Fungi)的藥物類別主要共分為三大類別。650Please respect copyright.PENANAvi1NpqRTQ5650Please respect copyright.PENANArRLpwIuyPr
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(圖2)三大類別的藥物機制雖有不同,但最終目的均是透過破壞真菌的外層結構來抑制其生長。650Please respect copyright.PENANAgNPE6NM284650Please respect copyright.PENANA2a23KstiBj
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1.Azole650Please respect copyright.PENANANsrQQnXlfp
抑制構成細胞膜的Ergosterol產生650Please respect copyright.PENANArMcMFM8dFY
2. Polyene650Please respect copyright.PENANA3IdDmSbuqA
消耗細胞膜的Ergosterol650Please respect copyright.PENANA2QukMk6WGl
3. Echinocandins650Please respect copyright.PENANA85Yg37xmBY
抑制構成細胞外層的糖分組織產生650Please respect copyright.PENANA3FNYQgvf4n
650Please respect copyright.PENANAIGZOpTMpmt
650Please respect copyright.PENANAeFlcK3emQh
(圖3)然而,現今出現了某一類別的Candida auris,上述三款的藥物均對它無法作出顯著功效。650Please respect copyright.PENANAgfVz8v77X4650Please respect copyright.PENANAkbf8ftpY39
650Please respect copyright.PENANAS7N7leSNA6
它能夠透過血液循環系統走進全身各部位,引發感染。650Please respect copyright.PENANAIp6iYIffp4
650Please respect copyright.PENANAIQ7ED4UO7E
就在2018年,英國急症室病人出現大規模Candida auris的感染,後來證實為共用探熱針所致(Ref1)。650Please respect copyright.PENANAvC20to4G9V
650Please respect copyright.PENANAhct6zFOImP
(圖4)有科學家近日發表文章(Ref2),在居住在深海生物的微生物中分離出命名為Turbinmicin的天然物質。650Please respect copyright.PENANAO3yUxaZjy1650Please respect copyright.PENANAhRTwPS5G1z
650Please respect copyright.PENANAzqZtm2v6lu
Turbinmicin能有效抑制不同真菌品種,包括Candida auris。650Please respect copyright.PENANAJkErSOrYO4
650Please respect copyright.PENANADASC3hm0aS
它的機制乃為影響內部的蛋白質運輸,與現今三類抑制外圍結構的機制不同,可能因而能夠擊殺得到抵擋現今三大類藥物的Candida auris。650Please respect copyright.PENANA0bzSto1VLe
650Please respect copyright.PENANA8OojR1yOh7
它並不會對人體的紅血球造成傷害,高劑量的使用亦沒有對老鼠做成影響,同時亦能治理Candida auris在老鼠體內所引發的感染。650Please respect copyright.PENANAF37brevO8n
650Please respect copyright.PENANAQDwwP47g76
但會否引起副作用或其他問題,還需要進一步的研究確實後,才能開啟人類試驗。650Please respect copyright.PENANAMQbGaACPn9
650Please respect copyright.PENANAn3JIGpeVrw
650Please respect copyright.PENANA3FCgZn37DC
深海一直是未被深入發掘的領域,這一次找到對抗耐藥真菌曙光,日後可能會繼續有意想不到的驚喜。650Please respect copyright.PENANAsX29CdMkmr
650Please respect copyright.PENANAziCJrsZDKX
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。650Please respect copyright.PENANA8B2piQz8VD
650Please respect copyright.PENANAQyGuGcE2Nx
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc650Please respect copyright.PENANAOQ9kO1Lr0b
650Please respect copyright.PENANA5W6QTPDDt6
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。650Please respect copyright.PENANAyDq7rvfdbu
650Please respect copyright.PENANA2EDaTQ7vHc
Link:650Please respect copyright.PENANApNvIZ9DtnC
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio650Please respect copyright.PENANA2nGUhbqMfL
650Please respect copyright.PENANAj0fR9VZBSP
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。650Please respect copyright.PENANAZvlHNHWgdc
650Please respect copyright.PENANAwhXxxWjfWK
https://www.instagram.com/potatopigtongue/650Please respect copyright.PENANAdRWUlpSKnC
650Please respect copyright.PENANASYeQWqyG2p
Ref1:https://www.nejm.org/doi/full/10.1056/NEJMc1900112650Please respect copyright.PENANABj2J1V1Iwu
Ref2:https://science.sciencemag.org/content/370/6519/974650Please respect copyright.PENANAykp9H8vuHq
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科普專欄–薯不揀單
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科普專欄–薯不揀單
Author:
薯仔聞茱莉

ISSUE #108
深入淺出–從深海生物中發掘出抗真菌藥物
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