科普專欄–薯不揀單 - 深入淺出–從深海生物中發掘出抗真菌藥物

真菌感染(Fungi Infection)約引致全球每年約二百萬人的死亡，而現今對抗真菌(Fungi)的藥物類別主要共分為三大類別。625Please respect copyright.ＰＥＮＡＮＡAvrUXur7dw
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（圖2）三大類別的藥物機制雖有不同，但最終目的均是透過破壞真菌的外層結構來抑制其生長。625Please respect copyright.ＰＥＮＡＮＡXQYi4NH4em
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1.Azole625Please respect copyright.ＰＥＮＡＮＡ61IRHDBWV1
抑制構成細胞膜的Ergosterol產生625Please respect copyright.ＰＥＮＡＮＡnjT2Bvqfms
2. Polyene625Please respect copyright.ＰＥＮＡＮＡmAgW3pUyah
消耗細胞膜的Ergosterol625Please respect copyright.ＰＥＮＡＮＡzQrZiIouxF
3. Echinocandins625Please respect copyright.ＰＥＮＡＮＡH8qV1ER0oH
抑制構成細胞外層的糖分組織產生625Please respect copyright.ＰＥＮＡＮＡ3F3nB6KPKK
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（圖3）然而，現今出現了某一類別的Candida auris，上述三款的藥物均對它無法作出顯著功效。625Please respect copyright.ＰＥＮＡＮＡHTtUpt3c5i
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它能夠透過血液循環系統走進全身各部位，引發感染。625Please respect copyright.ＰＥＮＡＮＡl533DeetwO
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就在2018年，英國急症室病人出現大規模Candida auris的感染，後來證實為共用探熱針所致（Ref1)。625Please respect copyright.ＰＥＮＡＮＡQAuTfi9fbH
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(圖4）有科學家近日發表文章（Ref2)，在居住在深海生物的微生物中分離出命名為Turbinmicin的天然物質。625Please respect copyright.ＰＥＮＡＮＡNISCzd1tFd
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Turbinmicin能有效抑制不同真菌品種，包括Candida auris。625Please respect copyright.ＰＥＮＡＮＡFwGVoTshDU
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它的機制乃為影響內部的蛋白質運輸，與現今三類抑制外圍結構的機制不同，可能因而能夠擊殺得到抵擋現今三大類藥物的Candida auris。625Please respect copyright.ＰＥＮＡＮＡ8Vuf1oobUv
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它並不會對人體的紅血球造成傷害，高劑量的使用亦沒有對老鼠做成影響，同時亦能治理Candida auris在老鼠體內所引發的感染。625Please respect copyright.ＰＥＮＡＮＡBstFn8XGVP
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但會否引起副作用或其他問題，還需要進一步的研究確實後，才能開啟人類試驗。625Please respect copyright.ＰＥＮＡＮＡxw5YIjFq92
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深海一直是未被深入發掘的領域，這一次找到對抗耐藥真菌曙光，日後可能會繼續有意想不到的驚喜。625Please respect copyright.ＰＥＮＡＮＡ6bY3yH9iPg
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。625Please respect copyright.ＰＥＮＡＮＡ8sCGctm9oT
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc625Please respect copyright.ＰＥＮＡＮＡFOf6v2f3gi
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。625Please respect copyright.ＰＥＮＡＮＡgclXZAcYym
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio625Please respect copyright.ＰＥＮＡＮＡOimAb3wofk
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。625Please respect copyright.ＰＥＮＡＮＡ1OladwJ6RC
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Ref1:https://www.nejm.org/doi/full/10.1056/NEJMc1900112625Please respect copyright.ＰＥＮＡＮＡHnJeJlJ4wi
Ref2:https://science.sciencemag.org/content/370/6519/974625Please respect copyright.ＰＥＮＡＮＡ2eW2u6qyjt

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