科普專欄–薯不揀單 - 深入淺出–從深海生物中發掘出抗真菌藥物

真菌感染(Fungi Infection)約引致全球每年約二百萬人的死亡，而現今對抗真菌(Fungi)的藥物類別主要共分為三大類別。673Please respect copyright.ＰＥＮＡＮＡrPWZfKJKJy
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（圖2）三大類別的藥物機制雖有不同，但最終目的均是透過破壞真菌的外層結構來抑制其生長。673Please respect copyright.ＰＥＮＡＮＡ1UezRLjgTP
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1.Azole673Please respect copyright.ＰＥＮＡＮＡJV0CS515dC
抑制構成細胞膜的Ergosterol產生673Please respect copyright.ＰＥＮＡＮＡ4OXh7BCBUa
2. Polyene673Please respect copyright.ＰＥＮＡＮＡHhXqP8tzEp
消耗細胞膜的Ergosterol673Please respect copyright.ＰＥＮＡＮＡTen3wpMR8o
3. Echinocandins673Please respect copyright.ＰＥＮＡＮＡO5IpvDI46A
抑制構成細胞外層的糖分組織產生673Please respect copyright.ＰＥＮＡＮＡ31hyMcAbLQ
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（圖3）然而，現今出現了某一類別的Candida auris，上述三款的藥物均對它無法作出顯著功效。673Please respect copyright.ＰＥＮＡＮＡa28f1QE5cI
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它能夠透過血液循環系統走進全身各部位，引發感染。673Please respect copyright.ＰＥＮＡＮＡ1Jq2kNwDoB
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就在2018年，英國急症室病人出現大規模Candida auris的感染，後來證實為共用探熱針所致（Ref1)。673Please respect copyright.ＰＥＮＡＮＡvCzpOFptlv
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(圖4）有科學家近日發表文章（Ref2)，在居住在深海生物的微生物中分離出命名為Turbinmicin的天然物質。673Please respect copyright.ＰＥＮＡＮＡDsJyzhGNfP
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Turbinmicin能有效抑制不同真菌品種，包括Candida auris。673Please respect copyright.ＰＥＮＡＮＡOpaXGeCev7
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它的機制乃為影響內部的蛋白質運輸，與現今三類抑制外圍結構的機制不同，可能因而能夠擊殺得到抵擋現今三大類藥物的Candida auris。673Please respect copyright.ＰＥＮＡＮＡVr1j96y7HX
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它並不會對人體的紅血球造成傷害，高劑量的使用亦沒有對老鼠做成影響，同時亦能治理Candida auris在老鼠體內所引發的感染。673Please respect copyright.ＰＥＮＡＮＡnUGByLYShU
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但會否引起副作用或其他問題，還需要進一步的研究確實後，才能開啟人類試驗。673Please respect copyright.ＰＥＮＡＮＡM3gxwV9G4p
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深海一直是未被深入發掘的領域，這一次找到對抗耐藥真菌曙光，日後可能會繼續有意想不到的驚喜。673Please respect copyright.ＰＥＮＡＮＡnT4Go7BpTU
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。673Please respect copyright.ＰＥＮＡＮＡtWhQSRPTyW
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc673Please respect copyright.ＰＥＮＡＮＡYqiMGDgEcs
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。673Please respect copyright.ＰＥＮＡＮＡIlX75QT8oR
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。673Please respect copyright.ＰＥＮＡＮＡKmoYZ9jFFw
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Ref1:https://www.nejm.org/doi/full/10.1056/NEJMc1900112673Please respect copyright.ＰＥＮＡＮＡgEjwD7vkzZ
Ref2:https://science.sciencemag.org/content/370/6519/974673Please respect copyright.ＰＥＮＡＮＡBlNA45jjpb

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