真菌感染(Fungi Infection)約引致全球每年約二百萬人的死亡,而現今對抗真菌(Fungi)的藥物類別主要共分為三大類別。600Please respect copyright.PENANAsfVe6SAahx600Please respect copyright.PENANAobWXqao4Xt
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(圖2)三大類別的藥物機制雖有不同,但最終目的均是透過破壞真菌的外層結構來抑制其生長。600Please respect copyright.PENANAiQOceVqCB4600Please respect copyright.PENANAtVgaAeqPfj
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1.Azole600Please respect copyright.PENANAsuVAsZHglP
抑制構成細胞膜的Ergosterol產生600Please respect copyright.PENANAX235ETeKJ5
2. Polyene600Please respect copyright.PENANA5wBj4CDhD9
消耗細胞膜的Ergosterol600Please respect copyright.PENANASZFJcaECgt
3. Echinocandins600Please respect copyright.PENANArSsCVM98ag
抑制構成細胞外層的糖分組織產生600Please respect copyright.PENANAiG0ZZt0qyh
600Please respect copyright.PENANAynkhYrJF58
600Please respect copyright.PENANA3oxCaRDGGv
(圖3)然而,現今出現了某一類別的Candida auris,上述三款的藥物均對它無法作出顯著功效。600Please respect copyright.PENANAVUGE2xb8kC600Please respect copyright.PENANAdzI1nH3i9Q
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它能夠透過血液循環系統走進全身各部位,引發感染。600Please respect copyright.PENANAz4zLu8ZoEs
600Please respect copyright.PENANA2P6qPa6m1D
就在2018年,英國急症室病人出現大規模Candida auris的感染,後來證實為共用探熱針所致(Ref1)。600Please respect copyright.PENANAVRPaSetey3
600Please respect copyright.PENANANCvSDaPjgd
(圖4)有科學家近日發表文章(Ref2),在居住在深海生物的微生物中分離出命名為Turbinmicin的天然物質。600Please respect copyright.PENANAR0m5G9sjSW600Please respect copyright.PENANAC29ULghBIb
600Please respect copyright.PENANAVfVtUqRIBR
Turbinmicin能有效抑制不同真菌品種,包括Candida auris。600Please respect copyright.PENANAWjcCw6s49j
600Please respect copyright.PENANA7TjKFOhtkw
它的機制乃為影響內部的蛋白質運輸,與現今三類抑制外圍結構的機制不同,可能因而能夠擊殺得到抵擋現今三大類藥物的Candida auris。600Please respect copyright.PENANArguuPTvtgt
600Please respect copyright.PENANAnD56lLgxYK
它並不會對人體的紅血球造成傷害,高劑量的使用亦沒有對老鼠做成影響,同時亦能治理Candida auris在老鼠體內所引發的感染。600Please respect copyright.PENANA06a7ou9Cz3
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但會否引起副作用或其他問題,還需要進一步的研究確實後,才能開啟人類試驗。600Please respect copyright.PENANA9QtGohxnnU
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深海一直是未被深入發掘的領域,這一次找到對抗耐藥真菌曙光,日後可能會繼續有意想不到的驚喜。600Please respect copyright.PENANAvjxqXzHA9a
600Please respect copyright.PENANASkJUZGuemF
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。600Please respect copyright.PENANAmtuf24egSh
600Please respect copyright.PENANAgljY6pY7cl
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc600Please respect copyright.PENANAj66P2M5EG6
600Please respect copyright.PENANAgBIGqDYlJZ
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。600Please respect copyright.PENANAa7jrvEsQT0
600Please respect copyright.PENANAsIJM5BEJ7i
Link:600Please respect copyright.PENANAJX4wR6k2lU
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio600Please respect copyright.PENANAr0rJNqmXQm
600Please respect copyright.PENANAyqQHdnVv0D
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。600Please respect copyright.PENANAFS8W3XWRyt
600Please respect copyright.PENANAtIzQMGWnvl
https://www.instagram.com/potatopigtongue/600Please respect copyright.PENANAetIGoml2C3
600Please respect copyright.PENANA5EItW070Eu
Ref1:https://www.nejm.org/doi/full/10.1056/NEJMc1900112600Please respect copyright.PENANAhsANz6EYuG
Ref2:https://science.sciencemag.org/content/370/6519/974600Please respect copyright.PENANARTwWx1lfFJ
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科普專欄–薯不揀單
作者:
薯仔聞茱莉

篇 #108
深入淺出–從深海生物中發掘出抗真菌藥物
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