科普專欄–薯不揀單 - 三十秒科學–基因突變對細胞的影響力（二)

腸道是我們身體其中一道消化器官，其內壁表面含有名為絨毛(villi)的結構，輔助營養的吸收;442Please respect copyright.ＰＥＮＡＮＡsydog3GXuR
而絨毛與絨毛之間，則有名為crypt的凹陷結構。442Please respect copyright.ＰＥＮＡＮＡU9fyz3pa5e
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(圖2)凹陷的crypt結構大多由幹細胞構成，它們會自我複製及演化，且不斷向上發展到達villi結構，形成可負責幫忙吸取營養的細胞。442Please respect copyright.ＰＥＮＡＮＡMY8I4ZIXC7
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(圖3)若位於crypt的幹細胞出現相應的基因突變(KrasG12D /PIK3CAH1047R )，它們會釋放出界別為BMP activator及WNT inactivator的物質，而當鄰近的正常細胞吸取這些物質後，出現基因突變的機率亦會提升。442Please respect copyright.ＰＥＮＡＮＡr9Il9XFfGC
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換句話說，只要一顆位於crypt的幹細胞出現突變的話，便會出現火燒連環船一樣的效果，一傳十十傳百的透導各鄰近的細胞出現異變，成為癌細胞的一份子。442Please respect copyright.ＰＥＮＡＮＡnLHbariMyP
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。442Please respect copyright.ＰＥＮＡＮＡf4NHl2T62R
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio442Please respect copyright.ＰＥＮＡＮＡgyyH0tIG8l
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Ref1:https://www.nature.com/articles/s41586-021-03605-0

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