科普專欄–薯不揀單 - 三十秒科學–鼻噴式武肺人造抗體

現今至少有兩間公司的人造抗體(LY/REGN)被緊急認可為武肺的治療方法。528Please respect copyright.ＰＥＮＡＮＡ7xbZrk7rl7
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但基於這兩種人造抗體需經由血管注射，其間病人需卧床約一小時間，且需求人手密切監察整個過程，實際運行的成本非常高昂，因此未能普及。528Please respect copyright.ＰＥＮＡＮＡ9dLaThpzcB
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更甚的是，有數據顯示當人造抗體經血管注射後，能抵達肺部裡頭的數量少至有少(血液抗體含量比肺部抗體含量高出200-500倍有多)，且已知當今的武肺病毒變種能有效躲避兩間公司的人造抗體追捕，使至人造抗體的地位日漸式微。528Please respect copyright.ＰＥＮＡＮＡNlbfuyI1VX
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(圖2)武肺病毒最主要的作惡地方是肺部，要解決肺部抗體含量過少的問題，其中一道手段就是從鼻腔注射人造抗體，使其能較易直達肺部。528Please respect copyright.ＰＥＮＡＮＡE0ycKnJzAM
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從老鼠模型實驗中，可以見到往鼻腔注射人造抗體後，抗體(紅黃色區域)會聚集在鼻腔(N)及肺部(Lu)裡頭。528Please respect copyright.ＰＥＮＡＮＡRX4l1hNybY
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(圖3)至於解決武肺變種的問題，其中一手段就是將五個單一抗體連結成一個個體(五合一)，利用「龐大」的身驅阻礙病毒進入細胞。528Please respect copyright.ＰＥＮＡＮＡvI4N4aQ1UC
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在老鼠實驗中，鼻噴式的五合一抗體能有效阻隔英國及巴西變種等病毒，且有著預防及治療武肺的功效，同時亦沒有對老鼠的體重和明顯特徵做成任何影響。528Please respect copyright.ＰＥＮＡＮＡ2j2uLc3n48
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若能順利通過人體臨床實驗，定必為世界的安定起來重要的作用。528Please respect copyright.ＰＥＮＡＮＡQCycpkgKxB
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。528Please respect copyright.ＰＥＮＡＮＡp15IF6Nh0l
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc528Please respect copyright.ＰＥＮＡＮＡy591D2BXex
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。528Please respect copyright.ＰＥＮＡＮＡyhSMFNZqIH
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Link:528Please respect copyright.ＰＥＮＡＮＡopxCzU5cCw
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio528Please respect copyright.ＰＥＮＡＮＡzu41uhLrgx
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。528Please respect copyright.ＰＥＮＡＮＡySNTXrQQ4h
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Ref1:https://www.nature.com/articles/s41586-021-03673-2_reference.pdf528Please respect copyright.ＰＥＮＡＮＡ8ASiwXPP2n

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