科普專欄–薯不揀單 - 深入淺出–免疫治療(Immunotherapy)手段醫治癌症(4)

這系列的第一集，我們講解了PD1/PDL1的運作原理。731Please respect copyright.ＰＥＮＡＮＡPgtfTjZgez
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第二集我們講述CTLA4與T cell功用的關係。731Please respect copyright.ＰＥＮＡＮＡM362TIExnm
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第三集我們講述增加T cell順利到達癌細胞位置的其中一種手段。731Please respect copyright.ＰＥＮＡＮＡvdTgtbbcCJ
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而這一集我們將講解一道關於檢測阻擋PD1的抗體Pembrolizumab成效的研究。731Please respect copyright.ＰＥＮＡＮＡqmKou01MeU
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關於阻檔PD1的原理及初心，可參閱第一集，其後可直接跳過第二第三集來到第四集本集。731Please respect copyright.ＰＥＮＡＮＡgfghbrwmuk
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（圖2）現今約只有20%的病人能夠從免疫治療中獲取長遠且持續的正面效果。731Please respect copyright.ＰＥＮＡＮＡ9MJAqUZSkP
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其有效的程度實屬可圈可點，如果有方法能夠盡快得知免疫治療沒有預期成效的話，那就可以即時轉用其他治療手段，把握時候嘗試用第二種方法入手打擊癌症。731Please respect copyright.ＰＥＮＡＮＡdlje5gdV4Z
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對此，有科學家嘗試量度血液中癌細胞的DNA含量，觀察能否藉此方法預判免疫治療的效果（Ref1)。731Please respect copyright.ＰＥＮＡＮＡEACMSYIBXg
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(圖3）癌細胞DNA之所以會出現在血液中，主要由兩大途徑所成。731Please respect copyright.ＰＥＮＡＮＡPh0Ehk43Oe
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1.癌細胞會利用血液循環系統或者淋巴系統轉移到第二個位置，731Please respect copyright.ＰＥＮＡＮＡxAjUUI6MPI
因此血液會有癌細胞的DNA。731Please respect copyright.ＰＥＮＡＮＡoEwGgYMx8r
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2.癌細胞亦會往外釋出名Exosome的物質，裡頭亦含有癌細胞的DNA。731Please respect copyright.ＰＥＮＡＮＡNaYXS658Wo
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在這裡，我們暫稱癌細胞在血液中的DNA為ctDNA，Circulating Tumor DNA。731Please respect copyright.ＰＥＮＡＮＡMZdErgfQNn
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（圖4）圖中為利用阻擋PD1的抗體Pembrolizumab作治療的兩名病人結果。731Please respect copyright.ＰＥＮＡＮＡmp1oUPvwDk
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紅線為電腦斷層掃描觀察癌細胞大小的影像，而黑線為量度癌細胞在血液(ctDNA)的含量，可見黑線(量度ctDNA的含量)能夠更快預判免疫治療結果成效。731Please respect copyright.ＰＥＮＡＮＡfK3XInPZ1a
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而且，有另外10名接受免疫治療的病人在初期(服用藥物後6-7星期)錄得ctDNA完全下降，亦同樣能夠比電腦斷層掃描觀察更早一步預判成效。731Please respect copyright.ＰＥＮＡＮＡu2FVaXN9Gp
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而研究中有45名免疫治療的病人在初期沒有錄得任何的ctDNA跌幅，癌細胞的體積在其後亦沒有明顯縮細。731Please respect copyright.ＰＥＮＡＮＡFe0XflW3JU
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對比含放射性的電腦斷層掃描，量度血液的ctDNA只需抽取病人的血液便可，明顯簡單且快捷。731Please respect copyright.ＰＥＮＡＮＡzfU18qlc7Q
只不過每名病人的ctDNA排組均不一樣，先前需要拿取部份癌細胞組織，才能夠有效設計檢測ctDNA的方針。731Please respect copyright.ＰＥＮＡＮＡR74NFftJLr
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無論如何，若然日後能有研究進一步確立此方法的成效及可信性，定必大可增加對抗癌症的效益。731Please respect copyright.ＰＥＮＡＮＡtBxfDkR9lu
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另一方面，透過檢測血液的DNA來預先得知癌細胞的存在，亦是日後檢驗及預防癌症的主流大方向。731Please respect copyright.ＰＥＮＡＮＡLMvU9AFQdV
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。731Please respect copyright.ＰＥＮＡＮＡMfuNxSAHUc
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc731Please respect copyright.ＰＥＮＡＮＡ8k67TFYwJr
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。731Please respect copyright.ＰＥＮＡＮＡtK6RlzyYjd
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio731Please respect copyright.ＰＥＮＡＮＡbO28vjydgN
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。731Please respect copyright.ＰＥＮＡＮＡwPs7GgeIJ9
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Ref1:https://www.nature.com/articles/s43018-020-009731Please respect copyright.ＰＥＮＡＮＡHTVDpYB7lO

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