此篇文章並非意圖貶損任何癌症的治療方法,純粹是轉述一宗失敗個案及其原因,探討從失敗中學習的過程。317Please respect copyright.PENANAGxNReuUd54
317Please respect copyright.PENANA78WmrXs5i8
利用免疫治療法來對抗癌症,早前我們已經花了不少篇幅講述。317Please respect copyright.PENANAiOQwQErKQ2
延伸閱讀:https://www.penana.com/article/500206317Please respect copyright.PENANAhQsKYWInZa
317Please respect copyright.PENANARaVVpfaAKX
317Please respect copyright.PENANAh9QBdVW0Fz
CAR T cell治療法,就是利用基因改造技術在免疫細胞外部加插辨識細胞的組件,引導它們更有效率殲滅對應的細胞;317Please respect copyright.PENANAmiIx71o0G7
在這個層面上,亦即是癌細胞。317Please respect copyright.PENANAd3GpkTaskU
317Please respect copyright.PENANAEfTL7ziXrN
(圖2)2010年,一名39歲女士患上腸癌,久經不同款式化療亦未見成效,故此便嘗試當時候較為新穎的CAR T cell 療法。317Please respect copyright.PENANAeCAkESIKqf
317Please respect copyright.PENANAuWGs5onpuw
317Please respect copyright.PENANAps5nQzQ5M2
她的腸癌細胞表面被診斷出持有非常多的ERBB2蛋白質,所以其治療的方式便是從她身上取得免疫細胞,再在實驗室裡培植加插能夠辨認ERBB2蛋白質的CAR T cell,再以將這些CAR T cell注入她體內,盼望這些CAR T cell會殲滅腸癌細胞。317Please respect copyright.PENANA6ruSxVBTRH
317Please respect copyright.PENANAPpuOzM2eGI
317Please respect copyright.PENANAJdU1ILeCly
(圖3)不幸的是,注入CAR T cell後的15分鐘,她出現呼吸困難等症狀,隨之亦送入ICU作出治療,唯5日後亦與世祥辭。317Please respect copyright.PENANAv3lOAjz1tw
317Please respect copyright.PENANA6eSVB3Pawg
317Please respect copyright.PENANAACAJafZmRq
最後經驗屍及分析各種數據後,相信是因為肺部含有微量ERBB2蛋白質,在抵達癌細胞位置前,那些CAR T cell率先與持有ERBB2的肺部細胞結合,產生過量的免疫反應,引致肺部器官發炎及衰竭,導致氧氣沒能輸送至各器官位置。317Please respect copyright.PENANAkW6HEmMGVl
317Please respect copyright.PENANAOwKRZsD8jL
在這手術進行之前,亦有不少針對ERBB2的CAR T cell人體試驗,箇中並沒有發生相同症狀。317Please respect copyright.PENANASJEkAEbf1n
317Please respect copyright.PENANApMmEOM4Ync
這相信是因為是次手術為了希望能夠順利殲滅癌細胞,其注入的T cell數量被以往實驗過多,因此就連ERBB2含量不多的肺部細胞亦被牽涉在內。317Please respect copyright.PENANA1nSSp8HwIY
317Please respect copyright.PENANAECZZ7VhdYm
無論如何,從這之經驗中可得知,ERBB2顯然並不是一道針對癌細胞的理想對象。317Please respect copyright.PENANAoIx4A6w7fm
317Please respect copyright.PENANAPkzZKp1GEb
317Please respect copyright.PENANAo3f7bBhvmT
317Please respect copyright.PENANAoT0YWN3kej
317Please respect copyright.PENANAayrgLFhrwF
317Please respect copyright.PENANAIUwgpEj0Fa
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。317Please respect copyright.PENANAv4JKnqwc3v
317Please respect copyright.PENANAlDtBFi8jUi
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc317Please respect copyright.PENANA7i9bl9s8ex
317Please respect copyright.PENANAyWF8iKomVa
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。317Please respect copyright.PENANAzhFcvVUn7Z
317Please respect copyright.PENANAafVsfdr0GD
Link:317Please respect copyright.PENANAduFzfxoF5v
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio317Please respect copyright.PENANAcSJrvYntB5
317Please respect copyright.PENANAghIxIeMHV7
317Please respect copyright.PENANALDuqI5swTc
除非Facebook及IG重開侵侵的account,否則我的IG將不會再作更新,只會寄居本土LIHKG及Penana。317Please respect copyright.PENANAKiqqzOMN4W
317Please respect copyright.PENANAqDsRd7M3Wm
Ref1:https://pubmed.ncbi.nlm.nih.gov/20179677/
317Please respect copyright.PENANAPF4vW8bhXk