科普專欄–薯不揀單 - 三十秒科學–癌症醫療失敗個案

此篇文章並非意圖貶損任何癌症的治療方法，純粹是轉述一宗失敗個案及其原因，探討從失敗中學習的過程。580Please respect copyright.ＰＥＮＡＮＡo3n3md5byI
580Please respect copyright.ＰＥＮＡＮＡnnLqRPgdHz
利用免疫治療法來對抗癌症，早前我們已經花了不少篇幅講述。580Please respect copyright.ＰＥＮＡＮＡWlZR9UkmNV
延伸閱讀:https://www.penana.com/article/500206580Please respect copyright.ＰＥＮＡＮＡfOOSdddOGP
580Please respect copyright.ＰＥＮＡＮＡeq9OuQoqkl
580Please respect copyright.ＰＥＮＡＮＡbnwcxav6L2
CAR T cell治療法，就是利用基因改造技術在免疫細胞外部加插辨識細胞的組件，引導它們更有效率殲滅對應的細胞;580Please respect copyright.ＰＥＮＡＮＡp9KIXU7dee
在這個層面上，亦即是癌細胞。580Please respect copyright.ＰＥＮＡＮＡzhOol3D6c2
580Please respect copyright.ＰＥＮＡＮＡZoedoK4cZl
(圖2)2010年，一名39歲女士患上腸癌，久經不同款式化療亦未見成效，故此便嘗試當時候較為新穎的CAR T cell 療法。580Please respect copyright.ＰＥＮＡＮＡYrl3z7WomV
580Please respect copyright.ＰＥＮＡＮＡBkAH9adkiM
580Please respect copyright.ＰＥＮＡＮＡnsamsTomJk
她的腸癌細胞表面被診斷出持有非常多的ERBB2蛋白質，所以其治療的方式便是從她身上取得免疫細胞，再在實驗室裡培植加插能夠辨認ERBB2蛋白質的CAR T cell，再以將這些CAR T cell注入她體內，盼望這些CAR T cell會殲滅腸癌細胞。580Please respect copyright.ＰＥＮＡＮＡCUBXOS1REj
580Please respect copyright.ＰＥＮＡＮＡlFEgtArJZl
580Please respect copyright.ＰＥＮＡＮＡQFYJuMRQqO
(圖3)不幸的是，注入CAR T cell後的15分鐘，她出現呼吸困難等症狀，隨之亦送入ICU作出治療，唯5日後亦與世祥辭。580Please respect copyright.ＰＥＮＡＮＡOFfY1m82kN
580Please respect copyright.ＰＥＮＡＮＡPAHgnlvP88
580Please respect copyright.ＰＥＮＡＮＡVhVM1a9vNm
最後經驗屍及分析各種數據後，相信是因為肺部含有微量ERBB2蛋白質，在抵達癌細胞位置前，那些CAR T cell率先與持有ERBB2的肺部細胞結合，產生過量的免疫反應，引致肺部器官發炎及衰竭，導致氧氣沒能輸送至各器官位置。580Please respect copyright.ＰＥＮＡＮＡ2VazDL039u
580Please respect copyright.ＰＥＮＡＮＡAD3ycpE3LF
在這手術進行之前，亦有不少針對ERBB2的CAR T cell人體試驗，箇中並沒有發生相同症狀。580Please respect copyright.ＰＥＮＡＮＡNnbuYvVNG1
580Please respect copyright.ＰＥＮＡＮＡWj19S7y5wY
這相信是因為是次手術為了希望能夠順利殲滅癌細胞，其注入的T cell數量被以往實驗過多，因此就連ERBB2含量不多的肺部細胞亦被牽涉在內。580Please respect copyright.ＰＥＮＡＮＡFUanJAjKso
580Please respect copyright.ＰＥＮＡＮＡItegl3uWNL
無論如何，從這之經驗中可得知，ERBB2顯然並不是一道針對癌細胞的理想對象。580Please respect copyright.ＰＥＮＡＮＡG2sCFEMdZd
580Please respect copyright.ＰＥＮＡＮＡmX6GD9vlv8
580Please respect copyright.ＰＥＮＡＮＡ0avdPep5UD
580Please respect copyright.ＰＥＮＡＮＡUZlQ3AeFO3
580Please respect copyright.ＰＥＮＡＮＡj0II75QrYV
580Please respect copyright.ＰＥＮＡＮＡ8ATUGAjJdH
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。580Please respect copyright.ＰＥＮＡＮＡkr8u02FUn4
580Please respect copyright.ＰＥＮＡＮＡ1fRnlqlzQC
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc580Please respect copyright.ＰＥＮＡＮＡp4Cn0WhP3q
580Please respect copyright.ＰＥＮＡＮＡmTMtuvFQ95
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。580Please respect copyright.ＰＥＮＡＮＡafHtgwp2pb
580Please respect copyright.ＰＥＮＡＮＡv31MFd0wPX
Link:580Please respect copyright.ＰＥＮＡＮＡGplhUkFoUr
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio580Please respect copyright.ＰＥＮＡＮＡG6nrkJ97o5
580Please respect copyright.ＰＥＮＡＮＡUyxgIKtlBy
580Please respect copyright.ＰＥＮＡＮＡnKNo7jBm6u
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。580Please respect copyright.ＰＥＮＡＮＡ6ZmY0FMtlf
580Please respect copyright.ＰＥＮＡＮＡELJ9KokwKf
Ref1:https://pubmed.ncbi.nlm.nih.gov/20179677/

580Please respect copyright.ＰＥＮＡＮＡSfbQQ68TYR

ns216.73.216.228da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章