科普專欄–薯不揀單 - 三十秒科學–藥物效果因人而異的其中一道解說

藥物的效用有時候因人而異，其中一道原因，可以歸究於每個人體內的腸道細菌品種有所不同所致。550Please respect copyright.ＰＥＮＡＮＡWdEnYGFe5T
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(圖2)口服藥物要抵達血管循環系統的話，無可避免將會途經我們的腸道。550Please respect copyright.ＰＥＮＡＮＡdu3jWWhDSC
而我們腸道的細菌有能力改造或代謝藥物，因而改變藥物結構及其效用。550Please respect copyright.ＰＥＮＡＮＡj4bvDitXYI
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(圖3)有科學家找來人體最為常見的76種腸道細菌品種，與271款不同界別常用的藥物共同放在一起12小時。550Please respect copyright.ＰＥＮＡＮＡuxcSuOR3am
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最終發現，271款藥物中，有多達176款藥物的濃度在被至少一種腸道細菌影響下，濃度減少了20%;550Please respect copyright.ＰＥＮＡＮＡ0It8DlKysl
而這些腸道細菌品種每款可以代謝11-95款藥物不等。550Please respect copyright.ＰＥＮＡＮＡfQmkaGTCfc
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用上老鼠作動物模型，科學家更能找出所屬細菌哪一條基因負責消化/代謝藥物，引證腸道細菌影響藥物吸收的理念。550Please respect copyright.ＰＥＮＡＮＡA2uCfB1XTg
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倘若你腸道恰巧住有細菌A，而細菌A又有能力吸收你所口服的藥物，那麼藥效便有可能會大大減低。550Please respect copyright.ＰＥＮＡＮＡARqx3dLpGN
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血液注射而非口服的藥物將有機會不受此限，因為藥物並不需一定要經過腸道裡頭。550Please respect copyright.ＰＥＮＡＮＡSd9Z0ddHLl
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。550Please respect copyright.ＰＥＮＡＮＡwpwt3TG5bb
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。550Please respect copyright.ＰＥＮＡＮＡIGTYHpTPMk
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Link:550Please respect copyright.ＰＥＮＡＮＡIansEtWvA3
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio550Please respect copyright.ＰＥＮＡＮＡOSEvv4cuQi
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。550Please respect copyright.ＰＥＮＡＮＡoV3g8X3grw
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Ref1:https://www.nature.com/articles/s41586-019-1291-3550Please respect copyright.ＰＥＮＡＮＡWlyF8xlHfD

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