科普專欄–薯不揀單 - <<深入淺出–武肺會否在急凍雞翼上大量繁殖>>

近日有急凍雞翼及其他產品被測量出擁有武肺存在，但武肺能否在雞翼或其他食物上大量繁殖呢？1008Please respect copyright.ＰＥＮＡＮＡt6sVGLSLFW
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答案是，不可以。1008Please respect copyright.ＰＥＮＡＮＡEazvmxLM4l
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武肺進行大量繁殖的話，必需要借助活生生的細胞幫忙，而其中先決的一步就是要進入細胞體內。1008Please respect copyright.ＰＥＮＡＮＡGJez9syJjO
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武肺可否入侵細胞，基本上視乎可唔可以達成下列3個條件。1008Please respect copyright.ＰＥＮＡＮＡjrhWpdvaHg
（圖1）1008Please respect copyright.ＰＥＮＡＮＡRzxJirtQJn
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1. S protein與細胞表面的ACE2觸碰。1008Please respect copyright.ＰＥＮＡＮＡDHeeBUmq1n
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2. 細胞表面ACE2與S protein的形狀吻合，亦即是「啱嘴形」。1008Please respect copyright.ＰＥＮＡＮＡXvfgMDZCIn
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3. 細胞表面擁有TMPRSS2蛋白質，能夠對S protein進行切割。1008Please respect copyright.ＰＥＮＡＮＡskDhUHwnEn
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滿足3大條件後，病毒就有能力能夠入侵細胞。1008Please respect copyright.ＰＥＮＡＮＡFS197307MT
當然，入侵細胞後還有很多因素決定武肺能否大量繁殖，但急凍雞翼連活生生的細胞也沒有，根本無可能可以大量繁殖。1008Please respect copyright.ＰＥＮＡＮＡONOez34E8k
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何謂S protein和ACE2，可到我之前所寫的文章溫故知新。1008Please respect copyright.ＰＥＮＡＮＡAAbRgv72ZH
https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/issue/91008Please respect copyright.ＰＥＮＡＮＡVJ9KHTjJ2V
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（圖2）1008Please respect copyright.ＰＥＮＡＮＡctnNF9MrpA
第二點所謂的「啱嘴型」，所指的就是ACE2的形狀能否與武肺的S protein形狀吻合，就好像砌Puzzle一樣，兩者不吻合的話就無法連結一起，勉強亦無幸福。1008Please respect copyright.ＰＥＮＡＮＡShIrfJGuq2
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如圖中所見，正因為老鼠ACE2唔啱嘴型，所以武肺無法引致老鼠患上肺炎等病徵，袁教授等人因此亦改用啱嘴型的倉鼠作為武肺的動物實驗模型。1008Please respect copyright.ＰＥＮＡＮＡh7UsFkdmeW
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（Ref 1)有科學家嘗試將武肺打落豬、雞和鴨身上，最終無法在牠們的任何器官身上找到武肺，而且亦沒有出現任何病徵，因此斷定牠們並不會受到武肺感染。1008Please respect copyright.ＰＥＮＡＮＡjeUh8a1ORF
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（圖3）1008Please respect copyright.ＰＥＮＡＮＡwElBVLhtu9
關於第三點，肺(Lung)及腎臟(Kidney)同樣擁有一定數量的ACE2及TMPRSS2（Ref2)，因此將會成為武肺的主要針對對象。1008Please respect copyright.ＰＥＮＡＮＡdVwosMIF1J
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而心臟(Heart) 同樣擁有一定數量的ACE2，某程度亦解釋了為何武肺患者康復後會被發現心臟出現異樣。1008Please respect copyright.ＰＥＮＡＮＡCXWWuQ0mj9
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而男性器官睪丸(Testis)，亦是ACE2數量較多的器官（圖中沒有列出），所以，嗯......1008Please respect copyright.ＰＥＮＡＮＡUKqMHIlttZ
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1008Please respect copyright.ＰＥＮＡＮＡdvTCCQL3AD
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1008Please respect copyright.ＰＥＮＡＮＡq41MNY4eSm
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同時亦可以在Penana網站裡按「買一嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1008Please respect copyright.ＰＥＮＡＮＡCLOL4nixxK
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1008Please respect copyright.ＰＥＮＡＮＡOapvgQcQZf
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有興趣接收科普資訊的話，歡迎follow IG: potatopigtongue。1008Please respect copyright.ＰＥＮＡＮＡrvuqi9MKzV
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Ref1:https://science.sciencemag.org/content/368/6494/10161008Please respect copyright.ＰＥＮＡＮＡDPsOQO8nUh
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Ref2:https://www.sciencedirect.com/science/article/pii/S221323172030820X#fig11008Please respect copyright.ＰＥＮＡＮＡM6t8PmjRn6

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