科普專欄–薯不揀單 - 三十秒科學–癌症所導致的體重流失(4)

要理解為何癌症會導致肌肉萎縮，其中的一道辦法就是對比萎縮肌肉與正常肌肉有甚麼分別，再以推敲其相關的機制。802Please respect copyright.ＰＥＮＡＮＡDY8L3h6k40
802Please respect copyright.ＰＥＮＡＮＡaDLGn5WPa3
802Please respect copyright.ＰＥＮＡＮＡa7onXssFEH
(圖2)研究發現，患癌老鼠的萎縮肌肉中，其名為ZIP14的蛋白質含量特別高企，且在患癌的老鼠但其肌肉並沒有萎縮的情況下， ZIP14的蛋白質含量並沒有顯著提升。802Please respect copyright.ＰＥＮＡＮＡKIxVd9iYJx
802Please respect copyright.ＰＥＮＡＮＡRmPqtVOMQ2
802Please respect copyright.ＰＥＮＡＮＡ0wEzx75rSf
(圖3)ZIP14蛋白質的主要作用是把鋅 (Zinc)輸送到細胞裡頭。802Please respect copyright.ＰＥＮＡＮＡ7AEmVOoraw
802Please respect copyright.ＰＥＮＡＮＡbQVRi4kUxh
802Please respect copyright.ＰＥＮＡＮＡ9bK5XcMVHw
科學家量度因癌症而導致萎縮的肌肉，發現肌肉的鋅 (Zinc)含量的確是比正常肌肉的為多，與其ZIP14蛋白質含量不謀而合。802Please respect copyright.ＰＥＮＡＮＡKZO43OetD5
802Please respect copyright.ＰＥＮＡＮＡhUBgeV3v1a
802Please respect copyright.ＰＥＮＡＮＡOM327Qf9wi
(圖4)利用基因工程移除ZIP14蛋白質的話，可以見得到患癌老鼠的肌肉細胞橫切面並沒有顯著的減少。802Please respect copyright.ＰＥＮＡＮＡs6gR2vOg24
802Please respect copyright.ＰＥＮＡＮＡxJdL6d6bO2
802Please respect copyright.ＰＥＮＡＮＡFXq2OoZR4s
再作一系列的實驗後，科學家推斷當癌細胞所釋出的TGFa/b物質到達肌肉位置後，便會引起肌肉ZIP14蛋白質含量上升，因而引起肌肉萎縮。802Please respect copyright.ＰＥＮＡＮＡvh7VGLk1IE
802Please respect copyright.ＰＥＮＡＮＡnalbt1VsAY
科學家們現正研究如何針對ZIP14蛋白質來抑制癌症所引致的肌肉萎縮，結果適目而待。802Please respect copyright.ＰＥＮＡＮＡkrdlNf7SIc
802Please respect copyright.ＰＥＮＡＮＡztAg8wPL3U
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。802Please respect copyright.ＰＥＮＡＮＡEaZXapWyv9
802Please respect copyright.ＰＥＮＡＮＡBEfBxlPXAP
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc802Please respect copyright.ＰＥＮＡＮＡEidImPz92f
802Please respect copyright.ＰＥＮＡＮＡ1jAC3kqAa6
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。802Please respect copyright.ＰＥＮＡＮＡ1FzVYF0NYb
802Please respect copyright.ＰＥＮＡＮＡ6Oh2noBNTV
Link:802Please respect copyright.ＰＥＮＡＮＡg7jfbdjPaa
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio802Please respect copyright.ＰＥＮＡＮＡiWmRaGd0lx
802Please respect copyright.ＰＥＮＡＮＡme2DXfN9iW
802Please respect copyright.ＰＥＮＡＮＡVDbXBugD5R
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。802Please respect copyright.ＰＥＮＡＮＡJFYdRtrECr
802Please respect copyright.ＰＥＮＡＮＡtZUkEzGsoR
Ref1:https://pubmed.ncbi.nlm.nih.gov/29875463/802Please respect copyright.ＰＥＮＡＮＡzpwFrEEOkg

ns216.73.216.237da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章