科普專欄–薯不揀單 - 三十秒科學–癌症所導致的體重流失(3)

癌細胞從原位轉移到另一器官，亦即是Metastasis，是癌病患者主要的死因。543Please respect copyright.ＰＥＮＡＮＡ4oJ9T1kOrw
543Please respect copyright.ＰＥＮＡＮＡ2IAO41NQrD
543Please respect copyright.ＰＥＮＡＮＡti4cDm4rFb
「有趣的是」，癌細胞雖近乎不會轉移到肌肉位置裡頭，但卻能從遠處釋放物質，經由血管抵達肌肉位置，催使肌肉萎縮，亦即是癌症惡病質(cancer cachexia)。543Please respect copyright.ＰＥＮＡＮＡPBw225h8yW
543Please respect copyright.ＰＥＮＡＮＡxoZWSzjV0b
(圖2)肌肉萎縮不但之令病人變得虛弱，難以接近正常劑量的化療，更為致命的是，當心臟肌肉及橫隔膜肌肉亦遭受到萎縮的時候，病人便會因呼吸困難等問題而逝死。543Please respect copyright.ＰＥＮＡＮＡnTqhjDtFA6
543Please respect copyright.ＰＥＮＡＮＡLpbg4f2X12
543Please respect copyright.ＰＥＮＡＮＡpSxuUTP3ig
早在1858年已有科學家指出cancer cachexia的存在，但至今2021年仍是沒有FDA認可藥物治療cancer cachexia。543Please respect copyright.ＰＥＮＡＮＡc4GQb5UAUN
543Please respect copyright.ＰＥＮＡＮＡ99CyeZh2e8
(圖3)現時有不少臨床研究希望可以制衡cancer cachexia，普遍均是從營養方面入手。543Please respect copyright.ＰＥＮＡＮＡSkCPohuT9e
543Please respect copyright.ＰＥＮＡＮＡf6iYeWvt9p
543Please respect copyright.ＰＥＮＡＮＡ71EtL3AOPK
但結果大多數是只能夠增加病人的脂肪組織，而沒能夠填補已萎縮的肌肉。543Please respect copyright.ＰＥＮＡＮＡ8xBHM8Br8B
543Please respect copyright.ＰＥＮＡＮＡfE0hycBS1d
有一點值得注意的是，肌肉細胞並非是死去，純粹是其分解蛋白質的進程比生產蛋白質的進程來得更快，因而形成萎縮。543Please respect copyright.ＰＥＮＡＮＡi5WCFYeYbA
543Please respect copyright.ＰＥＮＡＮＡyxdMnqSop5
543Please respect copyright.ＰＥＮＡＮＡKUFRvwcVB7
(圖4)從研究Cancer cachexia的老鼠模型中可以看到，患癌的老鼠不但更為細小，其手腕的握力度亦有所下降。543Please respect copyright.ＰＥＮＡＮＡFzQ584cEKf
543Please respect copyright.ＰＥＮＡＮＡuLiBesYFM2
543Please respect copyright.ＰＥＮＡＮＡProsECU064
觀察肌肉細胞橫切面的面積時，亦可以看到肌肉細胞的面積明顯有所縮細。543Please respect copyright.ＰＥＮＡＮＡyMbNsMBqib
543Please respect copyright.ＰＥＮＡＮＡu6eEsct1we
543Please respect copyright.ＰＥＮＡＮＡZ9tUE7sCRz
543Please respect copyright.ＰＥＮＡＮＡADfhNaHNCN
下集將會講解Cancer cachexia的老鼠模型所得出的其中一道結果。543Please respect copyright.ＰＥＮＡＮＡENjeZ8r8jJ
543Please respect copyright.ＰＥＮＡＮＡaA2sWSZM5f
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。543Please respect copyright.ＰＥＮＡＮＡLIjK6yL8AP
543Please respect copyright.ＰＥＮＡＮＡiS1JvuDS2j
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc543Please respect copyright.ＰＥＮＡＮＡjId7MVwTMw
543Please respect copyright.ＰＥＮＡＮＡc8GqTNV4LH
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。543Please respect copyright.ＰＥＮＡＮＡltbYrQgJuu
543Please respect copyright.ＰＥＮＡＮＡeq5jaEKDaI
Link:543Please respect copyright.ＰＥＮＡＮＡJscNSwvBUu
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio543Please respect copyright.ＰＥＮＡＮＡYZQPxRBtGP
543Please respect copyright.ＰＥＮＡＮＡNm43fK30si
543Please respect copyright.ＰＥＮＡＮＡOt9z9DCbyf
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。543Please respect copyright.ＰＥＮＡＮＡpjj9ZIrzX3
543Please respect copyright.ＰＥＮＡＮＡvqBkDrhbHQ
Ref1:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015555/543Please respect copyright.ＰＥＮＡＮＡnStn9rMcMI

ns216.73.216.228da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章