科普專欄–薯不揀單 - 三十秒科學–癌症所導致的體重流失(2)

此為上集的補充篇:三十秒科學–癌症所導致的體重流失440Please respect copyright.ＰＥＮＡＮＡFvv7xlP8o9
https://lih.kg/2397914440Please respect copyright.ＰＥＮＡＮＡmKY41noQ0S
440Please respect copyright.ＰＥＮＡＮＡ74t3h1sQNC
癌症惡病質(cancer cachexia)泛指因癌症而導致的體重流失，大部份情況下主要是由喪失肌肉所致，並沒法依靠進食來填補其喪失。440Please respect copyright.ＰＥＮＡＮＡA7yukCSocB
440Please respect copyright.ＰＥＮＡＮＡxxUwbrn5v8
440Please respect copyright.ＰＥＮＡＮＡ5RZhxYBv9q
在眾多癌症之中，高達接近70%的胰臟癌病人會出現cancer cachexia，總體重的損失在六個月內可高達25%。440Please respect copyright.ＰＥＮＡＮＡZPy6mL7kvo
相反，患上前列腺癌的病人僅只有約10%的人出現cancer cachexia。440Please respect copyright.ＰＥＮＡＮＡCRke3M14tv
440Please respect copyright.ＰＥＮＡＮＡ3KgpUbQe1n
440Please respect copyright.ＰＥＮＡＮＡiFX2C7vdtz
(圖2)病人出現cancer cachexia的話(以體重損失超過10%為指標)，其生存的機率亦會因而顯著下降。440Please respect copyright.ＰＥＮＡＮＡPiQ5704GFl
440Please respect copyright.ＰＥＮＡＮＡqq8qToWMLH
440Please respect copyright.ＰＥＮＡＮＡ8dBNh2EHrG
正因如此，若能了解其cancer cachexia機制並加以針對的話，將會是抵抗癌症的其中一道手法。440Please respect copyright.ＰＥＮＡＮＡHk0ACAfKgY
440Please respect copyright.ＰＥＮＡＮＡU8LNv3mGsx
440Please respect copyright.ＰＥＮＡＮＡr6VHrw54iE
(圖3)癌細胞所導致的體重流失，主要是由肌肉喪失所致。440Please respect copyright.ＰＥＮＡＮＡs7hxW2Uf8h
而當我們的肌肉受到傷害或撕裂的時候，裡頭的幹細胞以及圖中所指的細胞將會出手幫忙製造肌肉，填補其損失。440Please respect copyright.ＰＥＮＡＮＡOTrlQBwLi3
440Please respect copyright.ＰＥＮＡＮＡRmxW17awOM
440Please respect copyright.ＰＥＮＡＮＡIyxOEzrUCi
440Please respect copyright.ＰＥＮＡＮＡZJIAnGq3sN
癌細胞的厲害之處就是能夠釋出物質經由血管到達肌肉，誘導肌肉出現受傷情況之餘，並同時阻止肌肉幹細胞進行重生，因而導致肌肉流失情況發生。440Please respect copyright.ＰＥＮＡＮＡ2X0GqnZqcW
440Please respect copyright.ＰＥＮＡＮＡX8Gg9CkfAK
癌細胞之所以這樣做，其中的一道推論是希望透過破壞肌肉而使血液間的氨基酸(蛋白質)含量增加，然後借助肝臟把這些氨基酸轉變成糖份，再由血液循環系統輸送給自身所用。440Please respect copyright.ＰＥＮＡＮＡjfwpgBJ2z5
440Please respect copyright.ＰＥＮＡＮＡSCs2TZV63L
因著胰臟癌病人出現cancer cachexia的機率較高，有不少科學家均就此利用老鼠胰臟癌模型來研究cancer cachexia的機制。440Please respect copyright.ＰＥＮＡＮＡE6ndN4ZSsh
440Please respect copyright.ＰＥＮＡＮＡjiLCnJo0NA
至今已至少找出得到，癌細胞所釋出的物質會導致肌肉幹細胞一種名為Pax7的蛋白質含量不斷上升，並因而導致肌肉幹細胞沒法子進行重組肌肉舉動。440Please respect copyright.ＰＥＮＡＮＡKRRyjJse8y
440Please respect copyright.ＰＥＮＡＮＡPzhNABeSfl
440Please respect copyright.ＰＥＮＡＮＡajTjdCw96p
440Please respect copyright.ＰＥＮＡＮＡnLLUysTTit
440Please respect copyright.ＰＥＮＡＮＡf5CNq1T7Lb
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。440Please respect copyright.ＰＥＮＡＮＡNHgzPgvl6V
440Please respect copyright.ＰＥＮＡＮＡH9n6SZPlGu
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc440Please respect copyright.ＰＥＮＡＮＡKdFkzFH4Qz
440Please respect copyright.ＰＥＮＡＮＡKhh0AIg0Mv
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。440Please respect copyright.ＰＥＮＡＮＡeqHa82Fvar
440Please respect copyright.ＰＥＮＡＮＡ2CS1Vhg1Pk
Link:440Please respect copyright.ＰＥＮＡＮＡcmElH05Bxw
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio440Please respect copyright.ＰＥＮＡＮＡ2qsSKaNqWb
440Please respect copyright.ＰＥＮＡＮＡp6lq9EFGc3
440Please respect copyright.ＰＥＮＡＮＡQWVxPUVPcu
除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。440Please respect copyright.ＰＥＮＡＮＡh8J1S5CkcO
440Please respect copyright.ＰＥＮＡＮＡQRBYVoszqV
Ref1:https://www.nature.com/articles/nrdp2017105440Please respect copyright.ＰＥＮＡＮＡi8BwmRcdkY

ns216.73.216.47da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章