科普專欄–薯不揀單 - 深入淺出–延壽藥物的研究(一)

往不同動物例如老鼠及線蟲注射治療糖尿病的藥物(Metformin)後，壽命均會有顯著的增長。755Please respect copyright.ＰＥＮＡＮＡ5ifs8Peggv
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有研究利用現成資料庫作對比，發現服用Metformin的糖尿病人歲數比沒有服用Metformin的健康人士為長(Ref1)，亦有臨床研究嘗試為14名70歲的健康老人家注射為期6星期的Metformin，藉觀察體內的轉變以作抗衰老藥的研究基礎(Ref2)。755Please respect copyright.ＰＥＮＡＮＡCW14pVigov
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（圖2）從圖中可見，往年輕線蟲注射Metformin的話，牠們的生存日子便會增長。755Please respect copyright.ＰＥＮＡＮＡVMR32Fw2ai
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（圖3）但是，與年輕線蟲相反，往年老的線蟲注射Metformin的話，牠們的生存日子不但沒有增加，反而會減少。755Please respect copyright.ＰＥＮＡＮＡ3dXt98C2Ji
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（圖4）經過一系列的實驗，科學家認為Metformin能夠驅使年輕線蟲延壽的其中一個原因，是與粒線體的整體功用有關(Ref3)。755Please respect copyright.ＰＥＮＡＮＡ90VdVEzOcU
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其中，Metformin為年輕線蟲的新陳代謝作出轉變，包括增加碳水化合物的分解，減低脂肪的含量等，但年老的線蟲卻沒能夠觸發同樣的效果，反而更會因新陳代謝機制的不良負荷而增加死亡率。755Please respect copyright.ＰＥＮＡＮＡqpZOZo41aM
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文中的科學家亦就此作出質疑，既然Metformin只能使年輕線蟲而非年老線蟲延壽，那又究竟是否值得「魯莽」地對健康老人家進行Metformin的延壽研究。755Please respect copyright.ＰＥＮＡＮＡ2fxk3Uu9Zo
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。755Please respect copyright.ＰＥＮＡＮＡClaLfdATw2
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc755Please respect copyright.ＰＥＮＡＮＡOCHVAoSDYv
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。755Please respect copyright.ＰＥＮＡＮＡdXC6pN4sH5
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio755Please respect copyright.ＰＥＮＡＮＡ9B2TVRVSEu
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。755Please respect copyright.ＰＥＮＡＮＡ1blNsyDndw
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Ref1:https://pubmed.ncbi.nlm.nih.gov/25041462/755Please respect copyright.ＰＥＮＡＮＡAPoYj46RI7
Ref2:https://pubmed.ncbi.nlm.nih.gov/29383869/755Please respect copyright.ＰＥＮＡＮＡMhqqtuerge
Ref3:https://www.nature.com/articles/s42255-020-00307-1755Please respect copyright.ＰＥＮＡＮＡokDgEUCm85

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