科普專欄–薯不揀單 - 深入淺出–REGN武肺人造抗體的中期報告

注射武肺疫苗的主要目的，就是誘導身體產生對抗武肺病毒的抗體。507Please respect copyright.ＰＥＮＡＮＡr68FfkHd9O
507Please respect copyright.ＰＥＮＡＮＡtiEI0eaE30
507Please respect copyright.ＰＥＮＡＮＡpGgL7qyigN
但身體製造抗體需時，而且免疫系統薄弱的人士亦有可能沒法製造足夠數量的抗體。在這層面上，直接注射人造抗體的話，便能免去這兩道隱憂。507Please respect copyright.ＰＥＮＡＮＡBlzzF1shoV
507Please respect copyright.ＰＥＮＡＮＡsTp8PAPxsF
（圖2）從圖中所見，檢測者身體含有武肺抗體的話，身體的病毒數量相對上亦會較少，反之亦然。507Please respect copyright.ＰＥＮＡＮＡFCywpKwTI7
507Please respect copyright.ＰＥＮＡＮＡJPHlDmLemH
507Please respect copyright.ＰＥＮＡＮＡu8x9zzI5dR
可見病毒數量與體內抗體含量有著反比的關係。507Please respect copyright.ＰＥＮＡＮＡ2mang31EZ4
507Please respect copyright.ＰＥＮＡＮＡbMP0X59HOe
（圖3）現今有一推斷，體內武肺病毒數量越多的話，出現重症的機會亦會相繼增加。507Please respect copyright.ＰＥＮＡＮＡllNkr2kWQG
507Please respect copyright.ＰＥＮＡＮＡGiCrhwOOvO
507Please respect copyright.ＰＥＮＡＮＡ57x7jZDPxY
針對這一點，REGN公司進行臨床測試，為武肺患者注射兩款武肺人造抗體507Please respect copyright.ＰＥＮＡＮＡw793hrC1qr
casirivimab (REGN10933) 和imdevimab (REGN10987)，507Please respect copyright.ＰＥＮＡＮＡ2zu500F7Uy
觀察能否透過注射人造抗體來減低體內病毒的數量（Ref1)。507Please respect copyright.ＰＥＮＡＮＡ6WS1Jq1DWb
507Please respect copyright.ＰＥＮＡＮＡz6H4p4N7yQ
(圖4）分別往測試者注射安慰劑（灰線）、2g人造抗體（藍線）和8g人造抗體（綠線）後，可以見得到接受人造抗體注射的人士，其病毒在體內的下降速度比注射安慰劑的來得更快。507Please respect copyright.ＰＥＮＡＮＡZVCf94xpo9
507Please respect copyright.ＰＥＮＡＮＡbnmXtj17wy
507Please respect copyright.ＰＥＮＡＮＡss5m2QYYIf
（圖5）但若然在注射前已被驗出擁有武肺抗體的話，額外的人造抗體注射並不會導致病毒有顯著的加快下跌(右圖)；這有可能是體內的抗體本身已足夠應付現況。507Please respect copyright.ＰＥＮＡＮＡHmvumnu7a2
507Please respect copyright.ＰＥＮＡＮＡYL9b7mQFA8
507Please respect copyright.ＰＥＮＡＮＡXZN9lJZvzh
507Please respect copyright.ＰＥＮＡＮＡHwu5GYxcB3
（圖6）值得留意的是，本身病毒數量越多的話，人造抗體所促使的病毒量下跌效果便會越見明顯。507Please respect copyright.ＰＥＮＡＮＡqKPWNJh4UR
507Please respect copyright.ＰＥＮＡＮＡSa50VfD7g3
507Please respect copyright.ＰＥＮＡＮＡo9EYcaSTPM
亦即是代表當體外病毒數量超過某一定數量的時候，體內自身的抗體便會未能足以應付現況，而此時候所注射的人造抗體便會派上用場。507Please respect copyright.ＰＥＮＡＮＡ1RxnEGC3Cc
507Please respect copyright.ＰＥＮＡＮＡ3jv4qk5wDS
（圖7）人造抗體注射後的第28日，其濃度亦相對非常穩定，能給予注射人士一道保護時間。507Please respect copyright.ＰＥＮＡＮＡnEtav7RDf4
507Please respect copyright.ＰＥＮＡＮＡcLy7JNJoAu
507Please respect copyright.ＰＥＮＡＮＡrwOiE5uOUr
507Please respect copyright.ＰＥＮＡＮＡ8dXgUvfYde
人造抗體雖能加快病毒下降的速度，但能否預防重症這一方面並未有充份證據支持。507Please respect copyright.ＰＥＮＡＮＡN2dWJsGnUR
507Please respect copyright.ＰＥＮＡＮＡG0h1knLScU
而當患者已出現嚴重症狀後，注射人造抗體能否緩和或解決症狀亦是相當成疑。507Please respect copyright.ＰＥＮＡＮＡj7Xc9oIFc6
507Please respect copyright.ＰＥＮＡＮＡNCz2BB5Rtm
但無論如何，若然想達到在短時間內減低體內病毒的數量，人造抗體相信是其中一道的選擇。507Please respect copyright.ＰＥＮＡＮＡ7huCDKnwXT
507Please respect copyright.ＰＥＮＡＮＡbTofRnHh4y
507Please respect copyright.ＰＥＮＡＮＡVjfG75T7RH
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。507Please respect copyright.ＰＥＮＡＮＡ0XRm2TnM5n
507Please respect copyright.ＰＥＮＡＮＡuSjByiMLsD
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc507Please respect copyright.ＰＥＮＡＮＡDMHMSWLFW2
507Please respect copyright.ＰＥＮＡＮＡf6GNzD61ok
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。507Please respect copyright.ＰＥＮＡＮＡFaUbv9Wh6w
507Please respect copyright.ＰＥＮＡＮＡ0m5akakqPp
Link:507Please respect copyright.ＰＥＮＡＮＡ184TTMITHZ
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio507Please respect copyright.ＰＥＮＡＮＡmI9CdRdGiC
507Please respect copyright.ＰＥＮＡＮＡZgxquF1HBG
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。507Please respect copyright.ＰＥＮＡＮＡ1fhoYVfk7w
507Please respect copyright.ＰＥＮＡＮＡQys0WeMzy9
https://www.instagram.com/potatopigtongue/507Please respect copyright.ＰＥＮＡＮＡruzz81F0C8
507Please respect copyright.ＰＥＮＡＮＡ69ZRW7fuXT
507Please respect copyright.ＰＥＮＡＮＡMrobebvZG7
Ref1:https://www.nejm.org/doi/full/10.1056/NEJMoa2035002507Please respect copyright.ＰＥＮＡＮＡ4VKo8JBIvX