往不同動物例如老鼠及線蟲注射治療糖尿病的藥物(Metformin)後,壽命均會有顯著的增長。420Please respect copyright.PENANAfPrI2Upqvp420Please respect copyright.PENANA8V1kZyRlwD
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有研究利用現成資料庫作對比,發現服用Metformin的糖尿病人歲數比沒有服用Metformin的健康人士為長(Ref1),亦有臨床研究嘗試為14名70歲的健康老人家注射為期6星期的Metformin,藉觀察體內的轉變以作抗衰老藥的研究基礎(Ref2)。420Please respect copyright.PENANAmPG7OzLzRJ
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(圖2)從圖中可見,往年輕線蟲注射Metformin的話,牠們的生存日子便會增長。420Please respect copyright.PENANA3SvWOQPELL420Please respect copyright.PENANA4UnY38cQsk
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(圖3)但是,與年輕線蟲相反,往年老的線蟲注射Metformin的話,牠們的生存日子不但沒有增加,反而會減少。420Please respect copyright.PENANA5CaAIjapOk420Please respect copyright.PENANAGTX3eUYQwe
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(圖4)經過一系列的實驗,科學家認為Metformin能夠驅使年輕線蟲延壽的其中一個原因,是與粒線體的整體功用有關(Ref3)。420Please respect copyright.PENANAdmbAaRyRNu420Please respect copyright.PENANABQt7YMrKWB
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其中,Metformin為年輕線蟲的新陳代謝作出轉變,包括增加碳水化合物的分解,減低脂肪的含量等,但年老的線蟲卻沒能夠觸發同樣的效果,反而更會因新陳代謝機制的不良負荷而增加死亡率。420Please respect copyright.PENANAFmPuh5sFer
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文中的科學家亦就此作出質疑,既然Metformin只能使年輕線蟲而非年老線蟲延壽,那又究竟是否值得「魯莽」地對健康老人家進行Metformin的延壽研究。420Please respect copyright.PENANAllwQHjYLVT
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。420Please respect copyright.PENANARXVfXC5oib
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc420Please respect copyright.PENANA7FoOEMXsTa
420Please respect copyright.PENANAnwTlzYnG7o
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。420Please respect copyright.PENANAQEEJrzTHKK
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Link:420Please respect copyright.PENANAXaYMIq9Fvs
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio420Please respect copyright.PENANA9X7TNnAbLF
420Please respect copyright.PENANAeXNUzAn4wz
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。420Please respect copyright.PENANAbjmkasN52s
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https://www.instagram.com/potatopigtongue/420Please respect copyright.PENANAPXYQHH2QzJ
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Ref1:https://pubmed.ncbi.nlm.nih.gov/25041462/420Please respect copyright.PENANAnm19HSstkY
Ref2:https://pubmed.ncbi.nlm.nih.gov/29383869/420Please respect copyright.PENANASaqje9biAb
Ref3:https://www.nature.com/articles/s42255-020-00307-1420Please respect copyright.PENANA0SDHKWUPMm
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科普專欄–薯不揀單
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薯仔聞茱莉
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ISSUE #125
深入淺出–延壽藥物的研究(一)
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