往不同動物例如老鼠及線蟲注射治療糖尿病的藥物(Metformin)後,壽命均會有顯著的增長。691Please respect copyright.PENANASiPyrgWggC691Please respect copyright.PENANAVHovh6duw4
691Please respect copyright.PENANAUU6o38NFex
有研究利用現成資料庫作對比,發現服用Metformin的糖尿病人歲數比沒有服用Metformin的健康人士為長(Ref1),亦有臨床研究嘗試為14名70歲的健康老人家注射為期6星期的Metformin,藉觀察體內的轉變以作抗衰老藥的研究基礎(Ref2)。691Please respect copyright.PENANAmtzbxEhXAp
691Please respect copyright.PENANANu5Z7sYtW5
(圖2)從圖中可見,往年輕線蟲注射Metformin的話,牠們的生存日子便會增長。691Please respect copyright.PENANAywQ8xoyAMr691Please respect copyright.PENANAakkIvrQfbu
691Please respect copyright.PENANApaE6D9U1QK
(圖3)但是,與年輕線蟲相反,往年老的線蟲注射Metformin的話,牠們的生存日子不但沒有增加,反而會減少。691Please respect copyright.PENANAuSxFzXi6Gf691Please respect copyright.PENANAWAa8UZH9Ot
691Please respect copyright.PENANA0LrHOrHWDx
691Please respect copyright.PENANAga7WszEl61
(圖4)經過一系列的實驗,科學家認為Metformin能夠驅使年輕線蟲延壽的其中一個原因,是與粒線體的整體功用有關(Ref3)。691Please respect copyright.PENANAcRRXY1RzW8691Please respect copyright.PENANAtNUOea6l10
691Please respect copyright.PENANANtOe1Rq0fL
其中,Metformin為年輕線蟲的新陳代謝作出轉變,包括增加碳水化合物的分解,減低脂肪的含量等,但年老的線蟲卻沒能夠觸發同樣的效果,反而更會因新陳代謝機制的不良負荷而增加死亡率。691Please respect copyright.PENANAOGhPhP1cXL
691Please respect copyright.PENANABgcBthP94R
文中的科學家亦就此作出質疑,既然Metformin只能使年輕線蟲而非年老線蟲延壽,那又究竟是否值得「魯莽」地對健康老人家進行Metformin的延壽研究。691Please respect copyright.PENANA2yjbIq5zrY
691Please respect copyright.PENANAMB7rtpC3jQ
691Please respect copyright.PENANAka9yTSrfTa
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。691Please respect copyright.PENANAGDkoOmGbW4
691Please respect copyright.PENANAl7qnt5jGd6
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc691Please respect copyright.PENANA6494xtGaIA
691Please respect copyright.PENANAawh7cQxCGX
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。691Please respect copyright.PENANAWqjJnGTwKx
691Please respect copyright.PENANAf4imYzhdJX
Link:691Please respect copyright.PENANATVJJuzqgQK
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio691Please respect copyright.PENANAicAwkmckRw
691Please respect copyright.PENANAUdL8nvkD2Q
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。691Please respect copyright.PENANAuV5pUgJSwx
691Please respect copyright.PENANACOIFS60sjC
https://www.instagram.com/potatopigtongue/691Please respect copyright.PENANACWWZGGQLkz
691Please respect copyright.PENANABZjHpucxlj
691Please respect copyright.PENANAt3xsKoMGRH
691Please respect copyright.PENANATqjyZS4IVE
691Please respect copyright.PENANAYM7QbnQFoG
Ref1:https://pubmed.ncbi.nlm.nih.gov/25041462/691Please respect copyright.PENANAyuf7x6n7TF
Ref2:https://pubmed.ncbi.nlm.nih.gov/29383869/691Please respect copyright.PENANA74VmQJgmci
Ref3:https://www.nature.com/articles/s42255-020-00307-1691Please respect copyright.PENANA0ekaLLCcTg
arrow_back
科普專欄–薯不揀單
more_vert
-
info_outline 資料
-
toc 目錄
-
share 分享
-
format_color_text 介面設置
-
exposure_plus_1 推薦
-
打賞
-
report_problem 檢舉
-
account_circle 登入
X
科普專欄–薯不揀單
作者:
薯仔聞茱莉

篇 #125
深入淺出–延壽藥物的研究(一)
喜歡 2
閱讀 687
書籤 150
campaign
催更 0
打賞

按此加載下一章
X
每次催更後,作者都會收到通知!
smartphone100 → 催更
×
寫下你喜歡這個故事的地方
×
對此喜歡的人