肛門塞藥較會常用在兒童或不清醒的病人身上。基於大腸的表面面積非常大,而且鄰近血液循環系統,所以肝門塞藥大多時候均會比口服藥物更有效率進入血液裡頭。602Please respect copyright.PENANAsix7FWkiyv
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只不過最終是以口服還是肛門塞藥服用,請遵照醫生的吩咐及指示。602Please respect copyright.PENANAcwdnbnFYxy
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(圖2)有科學家受腸道鉤蟲啟發,設計出勾狀式藥物,並發表文章匯報成果(Ref1)。602Please respect copyright.PENANAV1RC9fCZvn
勾狀式藥物附上蠟質塗層,遇上體溫後便會溶化,並引致金屬制的勾爪抓緊腸道組織。602Please respect copyright.PENANAUgMVxVdGxU
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(圖3)利用儀器以高壓方式將勾狀式藥物送進腸道位置後,藥物便會從插著腸道內的金屬爪管道排出,進入血液循環系統裡頭。602Please respect copyright.PENANAcEhLeA8mAc
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(圖4)如圖中所見,紅線為勾狀式裝置包裝藥物肛塞進入老鼠腸道,而黑線為直接將藥物肛塞進入老鼠腸道的結果。602Please respect copyright.PENANAGW004aezKP
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利用勾狀式裝置包裝的方式送藥,藥物停留在血液的時間明顯有所增長!602Please respect copyright.PENANATIexRHoqIl
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而經過計算後,意欲往70kg成人輸送10mg Ketorolac的話,大概需要4900個1.5mm長的勾狀藥物。602Please respect copyright.PENANA3En7jhanjO
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文中的所有研究結果均透過老鼠身上所得,能否套用在人類身上使用為未知之數。602Please respect copyright.PENANAjiHNFWT7k3
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另一關於腸道送藥的研究,可參閱:https://www.penana.com/article/475900602Please respect copyright.PENANAkfXKedvrv0
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。602Please respect copyright.PENANAenYwghgYrm
602Please respect copyright.PENANAQcOOdV3dYv
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc602Please respect copyright.PENANAhS9PRLD9qt
602Please respect copyright.PENANAL5p92hU5Cl
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。602Please respect copyright.PENANArwFt3kOOpM
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Link:602Please respect copyright.PENANA5u6g8MdkA5
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio602Please respect copyright.PENANAh600qxpO2U
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有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。602Please respect copyright.PENANAkk82ztXxfa
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https://www.instagram.com/potatopigtongue/602Please respect copyright.PENANADgAOn4vDZa
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Ref1:https://advances.sciencemag.org/content/6/44/eabb4133602Please respect copyright.PENANAKvY1rQJaI8
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科普專欄–薯不揀單
Author:
薯仔聞茱莉
ISSUE #96
深入淺出–肛門塞藥的最新一道研究
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