這系列的第一集,我們講解了PD1/PDL1的運作原理。1340Please respect copyright.PENANACGJswR3Lji
Link: https://www.penana.com/article/4711251340Please respect copyright.PENANAj6YkL4Wwzm
1340Please respect copyright.PENANANvpIY5BUVR
第二集我們講述了CTLA4與T cell功用的關係。1340Please respect copyright.PENANAfU0vORa4c5
Link:https://www.penana.com/article/4724801340Please respect copyright.PENANAAgqMBrMDGQ1340Please respect copyright.PENANAAedm9CdwZw
1340Please respect copyright.PENANAaZ6EZffSdN
今次第三集這一篇,我們將會講述增加T cell有效抵達癌細胞所在位置的其中一種手段。1340Please respect copyright.PENANASLBZLD0n2T
1340Please respect copyright.PENANAD3HRo5ITXo
(圖2)有不少種類的癌細胞會抑壓與免疫系統相關的機制(RIG-1,JAK,PKR等等),從而盡量減低T cell或免疫細胞前來自身位置的機會。1340Please respect copyright.PENANARR0ohplMj9
1340Please respect copyright.PENANArL6WkRWEGE
但免疫系統機制的喪失或銳弱,換來的將會是失去抵禦病毒入侵的能力。1340Please respect copyright.PENANAhxviqEXPhU
1340Please respect copyright.PENANAhstKRjb8Lk1340Please respect copyright.PENANAMQP20iy65M
1340Please respect copyright.PENANA5dV7HjZEYK
而能夠在癌細胞裡頭任意進行複製及破壞的病毒,又不會對普通細胞進行過大傷害的,我們稱它為Oncolytic virus。1340Please respect copyright.PENANASn7SVYxTjn
1340Please respect copyright.PENANASO6HpMLup0
這些Oncolytic virus可以是自然存在的病毒,亦可以是被基因改造過的人工病毒。1340Please respect copyright.PENANAYbtiGRUwdl
2006年,中國批准利用Oncolytic virus手段醫治鼻咽癌,而2015年美國FDA及歐洲EMA亦批准這種手段可以用在醫治皮膚癌之上。1340Please respect copyright.PENANAMZ9xzqVb3y
1340Please respect copyright.PENANARidiJVFuaE
(圖3)近日有科學家發表文章(Ref1),結合Oncolytic virus及免疫系統治療方式來醫治實驗室細胞及老鼠身上的癌細胞。1340Please respect copyright.PENANABvjtoc7rMT1340Please respect copyright.PENANAopLd909SDw
1340Please respect copyright.PENANAWL02XCp206
他們利用基因改造方式製作Oncolytic virus,目的就是想細胞被病毒感染後會不斷產生沒有功用的tCD19組件。1340Please respect copyright.PENANAsnJRgyq5Rx
1340Please respect copyright.PENANAxaW8t859fg
在圖中可以清楚看得見,標記為藍色的癌細胞受到病毒感染後,會在自己外圍生產被標記為粉紅色的tCD19組件。1340Please respect copyright.PENANAbRJv5abmb9
1340Please respect copyright.PENANAe8PHAjVUuO
其後,他們製作出能夠辨認tCD19的T cell(整套技術的學術名稱為Chimeric antigen receptor T cell,這裡我們稱之為tCD19-CAR T cell),再放入老鼠身體之內。1340Please respect copyright.PENANAXeNWOvTBo9
1340Please respect copyright.PENANAD7SyEKVEi6
這些tCD19-CAR T cell只會辨認外圍擁有tCD19的細胞,並對其進行殲滅。1340Please respect copyright.PENANAsqbpGJNjqX
1340Please respect copyright.PENANARo2oKJ6PDO
因為tCD19並不自然存在普通細胞裡,所以它們只會殺滅受病毒感染的癌細胞;1340Please respect copyright.PENANAr5GPoprEPZ
普通健康細胞擁有健全的免疫系統相關機制,因此能夠阻止病毒在自己裡頭繁殖,亦避免了tCD19的產生。1340Please respect copyright.PENANAJN7MxdIIVR
1340Please respect copyright.PENANAig7eh25jtI
他們在文章清楚顯示,加進Oncolytic virus及tCD19-CAR T cell後能夠有效殺滅老鼠身上的癌細胞。同時他們亦發現得到,癌細胞被殺滅後會同時釋發出病毒,而病毒亦會順之然感染附近的癌細胞,以火燒連環船的方式將tCD19散發開去。1340Please respect copyright.PENANAFm5ExaFPO3
1340Please respect copyright.PENANA26bwq49DIG
這種手段能否在人體上實際運用,還需要一系列的改進及臨床實驗才能得出結論,但無疑的是若然能夠成功配上Oncolytic Virus及CAR Tcell的組合,定必能夠加強免疫細胞鎖定癌細胞所在位置的能力,以三管齊下的方式(PD1/CLTA4/Virus-CARTCell)把癌細胞滅絕。1340Please respect copyright.PENANArm60zhDW5d
1340Please respect copyright.PENANA9s0yQEfE1W1340Please respect copyright.PENANASzIyL5APKA
1340Please respect copyright.PENANAPJRpFIVRY8
1340Please respect copyright.PENANAIWIElzQ8Zw
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。1340Please respect copyright.PENANAdPjRxdspsh
1340Please respect copyright.PENANArn9exK9onl
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1340Please respect copyright.PENANAB8Jc0MofTU
1340Please respect copyright.PENANAaB0Rs5h8Ej
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。1340Please respect copyright.PENANAqNItgEBDag
1340Please respect copyright.PENANAw8STvj6rSg
Link:1340Please respect copyright.PENANAkJJzSzow5D
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1340Please respect copyright.PENANAyyDjGOp9qP
1340Please respect copyright.PENANA9B9HEwtcI0
1340Please respect copyright.PENANAtT0uGbOz9w
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。1340Please respect copyright.PENANA0jwqBphiLq
1340Please respect copyright.PENANAObp2SPoSKc
Ref1:https://stm.sciencemag.org/content/12/559/eaaz1863
arrow_back
科普專欄–薯不揀單
more_vert
-
info_outline 資料
-
toc 目錄
-
share 分享
-
format_color_text 介面設置
-
exposure_plus_1 推薦
-
打賞
-
report_problem 檢舉
-
account_circle 登入
X
科普專欄–薯不揀單
作者:
薯仔聞茱莉

篇 #44
深入淺出–免疫治療(Immunotherapy)手段醫治癌症(3)
喜歡 5
閱讀 1336
書籤 150
campaign
催更 0
打賞

按此加載下一章
X
每次催更後,作者都會收到通知!
smartphone100 → 催更
×
寫下你喜歡這個故事的地方
×
對此喜歡的人