科普專欄–薯不揀單 - 深入淺出–建構人造腸道厚膜的藥物

腸道是人體吸收葡萄糖的主要地方，亦是消化乳糖酵素(Lactase）的聚居地。1013Please respect copyright.ＰＥＮＡＮＡOuL8NXxs6X
缺乏Lactase的人並不建議進食含有乳糖的產品，否則會釀起肚痾、腹痛、作嘔等症狀，學名為Lactose Intolerance。1013Please respect copyright.ＰＥＮＡＮＡGUSJii6LKH
1013Please respect copyright.ＰＥＮＡＮＡaTMjazktjX
1013Please respect copyright.ＰＥＮＡＮＡjkqKIMUX5X
1013Please respect copyright.ＰＥＮＡＮＡheis2hIZtY
同時，腸道亦是寄生蟲的蝸居，飲用不乾淨水的話有機會讓血吸蟲寄生在腸道之中，引起血吸蟲病（Schistosomiasis)，為全球第二大僅次於瘧疾(Malaria)的寄生蟲病。1013Please respect copyright.ＰＥＮＡＮＡVd8RPUClhf
1013Please respect copyright.ＰＥＮＡＮＡVBcb8vcctk
1013Please respect copyright.ＰＥＮＡＮＡYAcThB6VZz
（圖2）近日，有科學家發表文章（Ref1)，他們研發出一款口服藥物，主要利用豬隻作為動物模型，證實豬隻吞下藥物後的12分鐘會腸道形成厚膜。1013Please respect copyright.ＰＥＮＡＮＡncSKQOYMxA
1013Please respect copyright.ＰＥＮＡＮＡOeh55dzCCG
1013Please respect copyright.ＰＥＮＡＮＡWY6QV2s6mI
此厚膜不會在其他器官上形成，而在24小時後厚膜亦會自然脫落，排出體外。1013Please respect copyright.ＰＥＮＡＮＡxIuvf33Tmz
1013Please respect copyright.ＰＥＮＡＮＡ22Tv1kgPRG
（圖3）根據口服藥物的配方不同，厚膜的特性亦能隨之轉變。1013Please respect copyright.ＰＥＮＡＮＡM9JX2XhUOO
1013Please respect copyright.ＰＥＮＡＮＡ3ovFYoBu4G
1013Please respect copyright.ＰＥＮＡＮＡKEV0ZILIeK
厚膜可配載消化乳糖酵素(Lactase)，對比沒有厚膜，能增強20倍酵素的能力，可消除Lactose Intolerance的問題。1013Please respect copyright.ＰＥＮＡＮＡdD4JorLXc5
1013Please respect copyright.ＰＥＮＡＮＡYk05P7S8Sr
而增強厚膜密度的話，亦可減少腸道吸收葡萄糖七成能力，這特點尤其受益於糖尿病人，能大幅度阻上血糖飄升。1013Please respect copyright.ＰＥＮＡＮＡFdgPZBuGcC
1013Please respect copyright.ＰＥＮＡＮＡXuJp5bELvh
另外，厚膜亦可配載殺寄生蟲藥(Praziquantel)，增加藥物滯留在腸道的時間，更有效率殺滅寄生蟲。1013Please respect copyright.ＰＥＮＡＮＡxHRSqaAG25
1013Please respect copyright.ＰＥＮＡＮＡbJjx7dUe5O
1013Please respect copyright.ＰＥＮＡＮＡT1YnynJhrH
（圖4）最為振奮的是，此方法在人類腸道組織亦見效，而且藥物對各種實驗室人體細胞亦無呈現有害效果。1013Please respect copyright.ＰＥＮＡＮＡqoH96If2OB
1013Please respect copyright.ＰＥＮＡＮＡiDNj3GXe53
1013Please respect copyright.ＰＥＮＡＮＡKWFt0SCbd2
老鼠服用藥物28日後，體重血壓等一切正常。1013Please respect copyright.ＰＥＮＡＮＡwAgGHR6qwj
1013Please respect copyright.ＰＥＮＡＮＡ4PTEeqzabv
若然此藥物能進一步在人類進行試驗的話，確立藥物運作正常及不會帶來任何副作用或安全問題的話，絕對大有潛質會成為治理糖尿病的新一代藥物。1013Please respect copyright.ＰＥＮＡＮＡAprJsq6d2M
1013Please respect copyright.ＰＥＮＡＮＡpiLjfmVEnN
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1013Please respect copyright.ＰＥＮＡＮＡs88nJYBFre
1013Please respect copyright.ＰＥＮＡＮＡJqj8I4AUpf
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1013Please respect copyright.ＰＥＮＡＮＡwJZB4TULoO
1013Please respect copyright.ＰＥＮＡＮＡEaiCVh46QE
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1013Please respect copyright.ＰＥＮＡＮＡCl1iWHxrgS
1013Please respect copyright.ＰＥＮＡＮＡl9lyYINwzY
Link:1013Please respect copyright.ＰＥＮＡＮＡ1AOpwqOjQA
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1013Please respect copyright.ＰＥＮＡＮＡPNip5kRwx1
1013Please respect copyright.ＰＥＮＡＮＡvp7j2r6AFc
1013Please respect copyright.ＰＥＮＡＮＡlZ9oZ4J4xf
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。1013Please respect copyright.ＰＥＮＡＮＡxgVuBiyBQf
1013Please respect copyright.ＰＥＮＡＮＡh11PhmFmIY
1013Please respect copyright.ＰＥＮＡＮＡt0DtSdPBaM
1013Please respect copyright.ＰＥＮＡＮＡ60uJq4ufbI
Ref1:https://stm.sciencemag.org/content/12/558/eabc0441

ns216.73.216.224da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章