癌症一直是備受關注的議題,至今已累積不少證據,癌細胞的新陳代謝與普通細胞有著與別不同的地方。803Please respect copyright.PENANAWLDoVwYxMZ
803Please respect copyright.PENANAHSlW6PgzUT
不少科學家深信,若然能夠針對癌細胞獨有的新陳代謝機制,將能更有效及針對性抑壓癌細胞的生長,甚至是殲滅它們。803Please respect copyright.PENANAENL297bKhD
803Please respect copyright.PENANA23Qe4q9aPf
近日,有科學家發表文章(Ref1),提出新的證據顯示新陳代謝對於癌細胞擴展的重要性。803Please respect copyright.PENANAjYkNHIIhsm
803Please respect copyright.PENANArNwxnt82xJ
圖1)講解文章內容之前,我們需要快速學習一下相關的術語。803Please respect copyright.PENANAJkWPVG58Fv
803Please respect copyright.PENANA6kU31Ihaez
803Please respect copyright.PENANAcX35Rpot1c
腫瘤由原來的位置轉移到另外一個器官,整個過程我們稱之為Metastasis。803Please respect copyright.PENANAYycfR3ttQ1
803Please respect copyright.PENANA5OBAoc8KX6
Primary Tumor(原發腫瘤)就是指原本被發現的癌細胞所在地,癌細胞會透過血液循環系統(Blood Circulatory System)或者淋巴系統(Lymphatic System)而從原本的位置轉移到另外一個器官,若然癌細胞能夠在第二個器官順利安頓下來及繁殖生長的話,我們會稱那腫瘤為Secondary Tumor(繼發性腫瘤)。803Please respect copyright.PENANASrcNZw7Bbw
803Please respect copyright.PENANApM0hgWQJDq
803Please respect copyright.PENANAJR166p0ad0
非常遺憾地,很多癌症病人的死因就在於Metastasis的發生,亦即是繼發性腫瘤的出現。803Please respect copyright.PENANAUduxmfo5h4
所以現今有不少科學家致力研究癌細胞Metastasis的機制,希望可以找出有效的方法阻止其發生。803Please respect copyright.PENANAckDYOGjMH1
803Please respect copyright.PENANA5a28WsJng4
803Please respect copyright.PENANAUwe6NsLVQx
(圖2)科學家們分別從30歲以下人士及60歲以上人士抽取其血清用作培養癌細胞之用。803Please respect copyright.PENANAzAiDzLISXY
803Please respect copyright.PENANA6CSzP0fsab
803Please respect copyright.PENANAjfYrjtaiD5
他們發現,利用60歲以上人士血清培養過的癌細胞,將比30歲以下人士的803Please respect copyright.PENANAaFE3HoDDi5
1.更呈化療藥物抗藥性803Please respect copyright.PENANAM2TIihj0Ax
2.更容易使癌細胞出現Metastasis803Please respect copyright.PENANARiyMkCKc0U
803Please respect copyright.PENANAwejIKUSQz1
803Please respect copyright.PENANAqyk9GC9DwO
(圖3)經過一大輪的實驗後,科學家們發現60歲以上人士的血清含有更多methylmalonic acid (MMA)。803Please respect copyright.PENANAtF3PwPGaNM
803Please respect copyright.PENANAG3DUSJygOX
803Please respect copyright.PENANA6b3aUM9DoO
當清除血清裡的MMA過後,血清亦因而失去誘導癌細胞發生Metastasis的功能;803Please respect copyright.PENANApafcSvRwm4
MMA的來源,已知是由代謝蛋白質及脂肪的時候會產生出來。803Please respect copyright.PENANASijNjL43en
803Please respect copyright.PENANAYqKGhJsuWa
而他們亦證實,脂肪結構會協助MMA更有效率進入癌細胞,誘發一系列的過程誘使Metastasis發生。803Please respect copyright.PENANALQL9AI3IYg
803Please respect copyright.PENANAMASmog2nJo
確實究竟是甚麼的脂肪結構,以及為何年老人士會有較多的MMA,暫時還沒能搞清楚。803Please respect copyright.PENANAZk5GfapbMk
803Please respect copyright.PENANAJATNTv19Z8
缺乏維他命B12,已被確定為會引致更多MMA的產生,但是從60歲以上人士的血清裡頭並沒有發現維他命B12與血清的MMA有直接的關聯,相信一定是有其他的原因導致MMA濃度的增加。803Please respect copyright.PENANAYUJ7YcIxTg
803Please respect copyright.PENANAihBeyvcNZB
要注意的是,文章所說的是,MMA有著誘導癌細胞進行Metastasis功效,而不是指MMA能夠誘導細胞轉化成為癌細胞。803Please respect copyright.PENANAIaIyBUU6Kb
803Please respect copyright.PENANAq0FvBRyL9f
803Please respect copyright.PENANAACgQMDHF0Z
總結來說,隨著歲數的增加,我們身體裡的MMA濃度亦會增加,提供了一個「良好」的環境讓癌細胞進行Metastasis。803Please respect copyright.PENANA9RGIWWCHB0
803Please respect copyright.PENANATwPYnECk3N
無論如何,如何想利用這結果來進一步發展日後的癌細胞醫療方法,還需要深入搞清楚裡頭的機制才行。803Please respect copyright.PENANAyySsPRjBoB
803Please respect copyright.PENANAAI34VLeWhj
803Please respect copyright.PENANAjPQLsKBzj3
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。803Please respect copyright.PENANAz4fya9DuLu
803Please respect copyright.PENANAhHCbOG0jH7
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc803Please respect copyright.PENANABx8cGbBV6J
803Please respect copyright.PENANAx1mYzCgXv0
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。803Please respect copyright.PENANA6f6xOklIqf
803Please respect copyright.PENANAlhaI1N3GIa
Link:803Please respect copyright.PENANADnxwK9GF7X
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio803Please respect copyright.PENANAzOP4UW4Un7
803Please respect copyright.PENANAbRHEG4NJKP
803Please respect copyright.PENANABO6eKgnKcP
有興趣接收科普資訊的話,歡迎follow IG: potatopigtongue。803Please respect copyright.PENANAKSytSs3cY5
803Please respect copyright.PENANARLSVexnT6R
803Please respect copyright.PENANAASZ0m5tTyh
Ref1:https://www.nature.com/articles/s41586-020-2630-0
arrow_back
科普專欄–薯不揀單
more_vert
-
info_outline Info
-
toc Table of Contents
-
share Share
-
format_color_text Display Settings
-
exposure_plus_1 Recommend
-
Sponsor
-
report_problem Report
-
account_circle Login
Search stories, writers or societies
Continue ReadingClear All
What Others Are ReadingRefresh
X
Never miss what's happening on Penana!
科普專欄–薯不揀單
Author:
薯仔聞茱莉
ISSUE #27
深入淺出–新陳代謝對於癌細胞的影響(一)
LIKES 1
READS 799
BOOKMARKS 148
campaign
Request update 0
Sponsor
Login with Facebook
or Sign up/Login to comment or bookmark!
Click to load the next chapter
X
After each update request, the author will receive a notification!
smartphone100 → Request update
X
Sponsor again
Click to login
Login first to show your name as a sponsor.
Thank you for supporting the story! :)
Please Login first.
×
Write down what you like about the story
×
Reading Theme:
Font Size:
Line Spacing:
Paragraph Spacing:
Load the next issue automatically
Reset to default
×
People Who Like This