科普專欄–薯不揀單 - 三十秒科學–潛伏在另一器官的癌細胞

癌細胞從原處走到另一地方(轉移，Metastasis)，均需透過血液或淋巴系統作交通渠道。612Please respect copyright.ＰＥＮＡＮＡs0bPjtVF9v
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有不少癌細胞轉移到另一器官後會呈「休養」狀態，不迅速繁殖，而是長期潛伏在另一器官內。612Please respect copyright.ＰＥＮＡＮＡl0IvyZMBl3
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因此就算沒能檢測得到循環腫瘤細胞的存在，也不百分百等於未來不會出現癌細胞轉移事件。612Please respect copyright.ＰＥＮＡＮＡJDqxWG7zSs
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(圖2)科學家分別把人類及老鼠的癌細胞注入到老鼠模型作研究，發現癌細胞發生轉移的機率是與目的地所含的NK cell數量有關係。612Please respect copyright.ＰＥＮＡＮＡXT4ppeFq3X
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目的地所含的NK cell越多，該地方出現癌細胞轉移的機率亦會越低。612Please respect copyright.ＰＥＮＡＮＡsRSxvrA8GR
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之所以會出現這情況，除了是NK cell殺死癌細胞這可能性之外，科學家發現NK cell會釋放interferon-γ (IFN-γ)的物質，誘使癌細胞進入休養狀態，不進行自我繁殖。612Please respect copyright.ＰＥＮＡＮＡ2JOwwllUQ6
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(圖3)奈何，至少在肝臟裡頭，一種名為Hepatic stellate cells會釋出CXCL12物質，CXCL12會阻礙NK cell的生長速度。612Please respect copyright.ＰＥＮＡＮＡXbgf80TY1V
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久而久之，便再也沒有足夠的NK cell抑制癌細胞的生長，而當潛伏在另一器官的癌細胞快速繁殖之時，這亦是轉移(Metastasis)被鑑定發生之時。612Please respect copyright.ＰＥＮＡＮＡvggCxSjjhy
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對此，研發藥物或療程確保NK cell長期處於足夠水平，或許是一道避免癌細胞發生轉移的大方向。612Please respect copyright.ＰＥＮＡＮＡw89o9wMfZO
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。612Please respect copyright.ＰＥＮＡＮＡFHvL63cFsx
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio612Please respect copyright.ＰＥＮＡＮＡJwUDDQ3w2t
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Ref1:https://www.nature.com/articles/s41586-021-03614-z612Please respect copyright.ＰＥＮＡＮＡ3QZTcBe1Ke

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