科普專欄–薯不揀單 - 三十秒科學–利用藥物抑制食慾以作對抗癡肥

減低食慾從而減少進食，某程度上亦可看成為對抗肥胖或癡肥的其中一道方法。1040Please respect copyright.ＰＥＮＡＮＡg2nhu4lnoP
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一直亦有不少研究試圖探討荷爾蒙與食慾的關係，1040Please respect copyright.ＰＥＮＡＮＡNeiE2pNzU4
其中之一的目標就是設計出一款能壓抑食慾的藥物，輔助癡肥或糖尿病人的治療。1040Please respect copyright.ＰＥＮＡＮＡ2Ux9yprzhN
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(圖2)我們的食慾由下丘腦(Hypothalamus)所控制。1040Please respect copyright.ＰＥＮＡＮＡRRaJvJUi6C
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以非常簡化的角度來說，在飽肚狀態下，含有MC4R蛋白質的神經細胞便會受到刺激，我們的食慾亦會隨之受到壓抑。1040Please respect copyright.ＰＥＮＡＮＡHU4jo6afxa
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相反，在飢餓狀態下，含有MC4R蛋白質的神經細胞便會受到壓抑，我們的食慾亦會隨之而來。1040Please respect copyright.ＰＥＮＡＮＡtlRXZiMInB
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老鼠缺乏MC4R蛋白質的話，體重亦會明顯上升。1040Please respect copyright.ＰＥＮＡＮＡA7YioESdaJ
而MC4R的蛋白質因基因變異而導致部份功能的喪失，亦能在不少癡肥人士身上記錄得到。1040Please respect copyright.ＰＥＮＡＮＡZCC172S9FD
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(圖3)刺激MC4R，便能減低食慾，減低食慾，便能減低進食量，有助對抗癡肥。1040Please respect copyright.ＰＥＮＡＮＡfZWIXTCW0K
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第一代刺激MC4R的藥物基於其附帶的血壓上升副作用，不得不終止研究及停止發展。1040Please respect copyright.ＰＥＮＡＮＡ5o6mzeR9CE
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而好消息的是，最近(2020年11月)FDA批准了新一代刺激MC4R的藥物Setmelanotide，並沒有血壓上升的副作用，在符合對應的條件下可用作體重管理之用。1040Please respect copyright.ＰＥＮＡＮＡOv4SPABnzQ
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1040Please respect copyright.ＰＥＮＡＮＡKOR7uvZp5k
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1040Please respect copyright.ＰＥＮＡＮＡpEyYIKuPsL
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1040Please respect copyright.ＰＥＮＡＮＡJLdJjk778Z
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Link:1040Please respect copyright.ＰＥＮＡＮＡVEABsrXXH0
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1040Please respect copyright.ＰＥＮＡＮＡ53XvmkqHGH
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。1040Please respect copyright.ＰＥＮＡＮＡBLpUQv9Vkx
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Ref1:https://pubmed.ncbi.nlm.nih.gov/33137293/1040Please respect copyright.ＰＥＮＡＮＡTUBNohLpeu
Ref2:https://www.sciencedirect.com/science/article/pii/S22128778210004661040Please respect copyright.ＰＥＮＡＮＡG8HTLjFh2G
Ref3:https://pubmed.ncbi.nlm.nih.gov/9019399/1040Please respect copyright.ＰＥＮＡＮＡ9jiwFHqmvm
Ref4:https://pubmed.ncbi.nlm.nih.gov/12646665/1040Please respect copyright.ＰＥＮＡＮＡ0NSvVOxtFj
Ref5:https://pubmed.ncbi.nlm.nih.gov/18454148/1040Please respect copyright.ＰＥＮＡＮＡQrOKjtEYB1

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