科普專欄–薯不揀單 - 三十秒科學–癌症醫療失敗個案

此篇文章並非意圖貶損任何癌症的治療方法，純粹是轉述一宗失敗個案及其原因，探討從失敗中學習的過程。751Please respect copyright.ＰＥＮＡＮＡ0GQCGqbidk
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利用免疫治療法來對抗癌症，早前我們已經花了不少篇幅講述。751Please respect copyright.ＰＥＮＡＮＡN6wCtJIxWO
延伸閱讀:https://www.penana.com/article/500206751Please respect copyright.ＰＥＮＡＮＡUccRXOvDw5
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CAR T cell治療法，就是利用基因改造技術在免疫細胞外部加插辨識細胞的組件，引導它們更有效率殲滅對應的細胞;751Please respect copyright.ＰＥＮＡＮＡjbou0FRG08
在這個層面上，亦即是癌細胞。751Please respect copyright.ＰＥＮＡＮＡCZUxCALgaj
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(圖2)2010年，一名39歲女士患上腸癌，久經不同款式化療亦未見成效，故此便嘗試當時候較為新穎的CAR T cell 療法。751Please respect copyright.ＰＥＮＡＮＡddO3ua3vyy
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她的腸癌細胞表面被診斷出持有非常多的ERBB2蛋白質，所以其治療的方式便是從她身上取得免疫細胞，再在實驗室裡培植加插能夠辨認ERBB2蛋白質的CAR T cell，再以將這些CAR T cell注入她體內，盼望這些CAR T cell會殲滅腸癌細胞。751Please respect copyright.ＰＥＮＡＮＡBGIzdgMJWy
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(圖3)不幸的是，注入CAR T cell後的15分鐘，她出現呼吸困難等症狀，隨之亦送入ICU作出治療，唯5日後亦與世祥辭。751Please respect copyright.ＰＥＮＡＮＡGz6oRwZtAI
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最後經驗屍及分析各種數據後，相信是因為肺部含有微量ERBB2蛋白質，在抵達癌細胞位置前，那些CAR T cell率先與持有ERBB2的肺部細胞結合，產生過量的免疫反應，引致肺部器官發炎及衰竭，導致氧氣沒能輸送至各器官位置。751Please respect copyright.ＰＥＮＡＮＡwGVWktXFod
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在這手術進行之前，亦有不少針對ERBB2的CAR T cell人體試驗，箇中並沒有發生相同症狀。751Please respect copyright.ＰＥＮＡＮＡroRnRjRxVk
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這相信是因為是次手術為了希望能夠順利殲滅癌細胞，其注入的T cell數量被以往實驗過多，因此就連ERBB2含量不多的肺部細胞亦被牽涉在內。751Please respect copyright.ＰＥＮＡＮＡ5FDSj8O3wJ
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無論如何，從這之經驗中可得知，ERBB2顯然並不是一道針對癌細胞的理想對象。751Please respect copyright.ＰＥＮＡＮＡ6hosR3nTp2
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。751Please respect copyright.ＰＥＮＡＮＡ4dgBwPDxDd
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。751Please respect copyright.ＰＥＮＡＮＡCUTSoJBbVQ
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。751Please respect copyright.ＰＥＮＡＮＡXBvA2dSVJL
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Ref1:https://pubmed.ncbi.nlm.nih.gov/20179677/

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