科普專欄–薯不揀單 - 三十秒科學–藥物效果因人而異的其中一道解說

藥物的效用有時候因人而異，其中一道原因，可以歸究於每個人體內的腸道細菌品種有所不同所致。543Please respect copyright.ＰＥＮＡＮＡ4yCk851bat
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(圖2)口服藥物要抵達血管循環系統的話，無可避免將會途經我們的腸道。543Please respect copyright.ＰＥＮＡＮＡzkmPmOrvMz
而我們腸道的細菌有能力改造或代謝藥物，因而改變藥物結構及其效用。543Please respect copyright.ＰＥＮＡＮＡPDTOjBQ7EI
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(圖3)有科學家找來人體最為常見的76種腸道細菌品種，與271款不同界別常用的藥物共同放在一起12小時。543Please respect copyright.ＰＥＮＡＮＡzdEojf5ToX
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最終發現，271款藥物中，有多達176款藥物的濃度在被至少一種腸道細菌影響下，濃度減少了20%;543Please respect copyright.ＰＥＮＡＮＡ64sn0qOLig
而這些腸道細菌品種每款可以代謝11-95款藥物不等。543Please respect copyright.ＰＥＮＡＮＡkbTMe8xL65
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用上老鼠作動物模型，科學家更能找出所屬細菌哪一條基因負責消化/代謝藥物，引證腸道細菌影響藥物吸收的理念。543Please respect copyright.ＰＥＮＡＮＡLHbpZI9UIc
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倘若你腸道恰巧住有細菌A，而細菌A又有能力吸收你所口服的藥物，那麼藥效便有可能會大大減低。543Please respect copyright.ＰＥＮＡＮＡvpnzMT8NL5
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血液注射而非口服的藥物將有機會不受此限，因為藥物並不需一定要經過腸道裡頭。543Please respect copyright.ＰＥＮＡＮＡT4K3mC9gNz
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。543Please respect copyright.ＰＥＮＡＮＡulI2wnI8aG
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc543Please respect copyright.ＰＥＮＡＮＡnETvjpg4zU
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。543Please respect copyright.ＰＥＮＡＮＡyHuX6neH5O
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Link:543Please respect copyright.ＰＥＮＡＮＡWhP4XIWFoN
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio543Please respect copyright.ＰＥＮＡＮＡ3g6ESwOnIK
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。543Please respect copyright.ＰＥＮＡＮＡZCfXLXHc7J
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Ref1:https://www.nature.com/articles/s41586-019-1291-3543Please respect copyright.ＰＥＮＡＮＡqwWrz98rWi

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