科普專欄–薯不揀單 - <<深入淺出–武肺會否在急凍雞翼上大量繁殖>>

近日有急凍雞翼及其他產品被測量出擁有武肺存在，但武肺能否在雞翼或其他食物上大量繁殖呢？977Please respect copyright.ＰＥＮＡＮＡDO8ns9kSwf
977Please respect copyright.ＰＥＮＡＮＡdvImADhduD
答案是，不可以。977Please respect copyright.ＰＥＮＡＮＡKJ0Ru8ALyU
977Please respect copyright.ＰＥＮＡＮＡukoLJS22aY
武肺進行大量繁殖的話，必需要借助活生生的細胞幫忙，而其中先決的一步就是要進入細胞體內。977Please respect copyright.ＰＥＮＡＮＡDmsxFOhsIL
977Please respect copyright.ＰＥＮＡＮＡmmGFw6z1IA
武肺可否入侵細胞，基本上視乎可唔可以達成下列3個條件。977Please respect copyright.ＰＥＮＡＮＡR0pYaEveTE
（圖1）977Please respect copyright.ＰＥＮＡＮＡ6pdttA3zvT
977Please respect copyright.ＰＥＮＡＮＡQTOlnmRw1u
977Please respect copyright.ＰＥＮＡＮＡM8B09vJhe9
1. S protein與細胞表面的ACE2觸碰。977Please respect copyright.ＰＥＮＡＮＡcT9nOXCD5w
977Please respect copyright.ＰＥＮＡＮＡzcLigcwqKE
2. 細胞表面ACE2與S protein的形狀吻合，亦即是「啱嘴形」。977Please respect copyright.ＰＥＮＡＮＡipmIddeqtT
977Please respect copyright.ＰＥＮＡＮＡHSpgJMAKrE
3. 細胞表面擁有TMPRSS2蛋白質，能夠對S protein進行切割。977Please respect copyright.ＰＥＮＡＮＡtzumqtEh72
977Please respect copyright.ＰＥＮＡＮＡGneAtCpClO
滿足3大條件後，病毒就有能力能夠入侵細胞。977Please respect copyright.ＰＥＮＡＮＡaHXD3zHfrv
當然，入侵細胞後還有很多因素決定武肺能否大量繁殖，但急凍雞翼連活生生的細胞也沒有，根本無可能可以大量繁殖。977Please respect copyright.ＰＥＮＡＮＡ5iVNTlpZ1J
977Please respect copyright.ＰＥＮＡＮＡch5xbzoSIj
何謂S protein和ACE2，可到我之前所寫的文章溫故知新。977Please respect copyright.ＰＥＮＡＮＡfkpZIMok95
https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/issue/9977Please respect copyright.ＰＥＮＡＮＡ08UzzMmM7L
977Please respect copyright.ＰＥＮＡＮＡWsGlq82a35
977Please respect copyright.ＰＥＮＡＮＡB8qmGkl4ZZ
977Please respect copyright.ＰＥＮＡＮＡsh7PWrrVyu
（圖2）977Please respect copyright.ＰＥＮＡＮＡ5rkpTF2Yec
第二點所謂的「啱嘴型」，所指的就是ACE2的形狀能否與武肺的S protein形狀吻合，就好像砌Puzzle一樣，兩者不吻合的話就無法連結一起，勉強亦無幸福。977Please respect copyright.ＰＥＮＡＮＡhPbeoNfnOr
977Please respect copyright.ＰＥＮＡＮＡ0Zdim3NfZK
如圖中所見，正因為老鼠ACE2唔啱嘴型，所以武肺無法引致老鼠患上肺炎等病徵，袁教授等人因此亦改用啱嘴型的倉鼠作為武肺的動物實驗模型。977Please respect copyright.ＰＥＮＡＮＡDzeW50EuB2
977Please respect copyright.ＰＥＮＡＮＡEcWXV7B4R8
（Ref 1)有科學家嘗試將武肺打落豬、雞和鴨身上，最終無法在牠們的任何器官身上找到武肺，而且亦沒有出現任何病徵，因此斷定牠們並不會受到武肺感染。977Please respect copyright.ＰＥＮＡＮＡCSYHwHx0Tm
977Please respect copyright.ＰＥＮＡＮＡMriD4Xoj9L
977Please respect copyright.ＰＥＮＡＮＡo1JKUOkslA
（圖3）977Please respect copyright.ＰＥＮＡＮＡzzVnERb4fV
關於第三點，肺(Lung)及腎臟(Kidney)同樣擁有一定數量的ACE2及TMPRSS2（Ref2)，因此將會成為武肺的主要針對對象。977Please respect copyright.ＰＥＮＡＮＡxxWtTNQws1
977Please respect copyright.ＰＥＮＡＮＡgWGh1Z1e1C
而心臟(Heart) 同樣擁有一定數量的ACE2，某程度亦解釋了為何武肺患者康復後會被發現心臟出現異樣。977Please respect copyright.ＰＥＮＡＮＡY8xLEvCGPX
977Please respect copyright.ＰＥＮＡＮＡgmHjtpV7eP
977Please respect copyright.ＰＥＮＡＮＡNykDALqlxq
而男性器官睪丸(Testis)，亦是ACE2數量較多的器官（圖中沒有列出），所以，嗯......977Please respect copyright.ＰＥＮＡＮＡi1ZBYRYT8P
977Please respect copyright.ＰＥＮＡＮＡQFu2nPyDiJ
977Please respect copyright.ＰＥＮＡＮＡ5BRipmRgMY
977Please respect copyright.ＰＥＮＡＮＡQh3PgBFexP
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。977Please respect copyright.ＰＥＮＡＮＡJeXqHPBsaX
977Please respect copyright.ＰＥＮＡＮＡ8nCjw60PtV
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc977Please respect copyright.ＰＥＮＡＮＡSAAy1ZXcq0
977Please respect copyright.ＰＥＮＡＮＡGAG0UyCEwc
同時亦可以在Penana網站裡按「買一嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。977Please respect copyright.ＰＥＮＡＮＡmd5cDMwmsC
977Please respect copyright.ＰＥＮＡＮＡYNoO9eTVLc
Link:977Please respect copyright.ＰＥＮＡＮＡjZesfnVGWs
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio977Please respect copyright.ＰＥＮＡＮＡPmkn0iJRT1
977Please respect copyright.ＰＥＮＡＮＡn2hRNneujY
977Please respect copyright.ＰＥＮＡＮＡnzWiKeQdXf
有興趣接收科普資訊的話，歡迎follow IG: potatopigtongue。977Please respect copyright.ＰＥＮＡＮＡwfTeWxk9Nz
977Please respect copyright.ＰＥＮＡＮＡcPY1IWWFqx
977Please respect copyright.ＰＥＮＡＮＡDE1rrKoZUO
977Please respect copyright.ＰＥＮＡＮＡaIjenc1Uu4
977Please respect copyright.ＰＥＮＡＮＡve9xzRhOUU
977Please respect copyright.ＰＥＮＡＮＡSpZ8XACjaR
Ref1:https://science.sciencemag.org/content/368/6494/1016977Please respect copyright.ＰＥＮＡＮＡp3sq2kLu2U
977Please respect copyright.ＰＥＮＡＮＡQPBZdSE81Z
Ref2:https://www.sciencedirect.com/science/article/pii/S221323172030820X#fig1977Please respect copyright.ＰＥＮＡＮＡ7udIHnrq9D

ns216.73.216.224da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章