骨髓(Bone Marrow)是不少幹細胞的聚居地，而紅血球、白血球、血小板等都是從骨髓裡頭的幹細胞而來。1382Please respect copyright.ＰＥＮＡＮＡoV5mK8xQXL
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（圖2）老鼠在跑動滾輪運動四星期後，其頭腦骨髓裡專門負責製造免疫細胞的幹細胞數量並沒有明顯改變。1382Please respect copyright.ＰＥＮＡＮＡwp4ToUL6hf
而在運動時候所用到的腳骨內，專門負責製造免疫細胞的幹細胞數量則有所增加。1382Please respect copyright.ＰＥＮＡＮＡL6LWQnF76X
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（圖3）研究發現（Ref1)，骨髓裡某類型的幹細胞表面有著名為Pizeo1的蛋白質。1382Please respect copyright.ＰＥＮＡＮＡygRKENw9pH
當它受到運動等的物理刺激後，便會催動自身幹細胞演變成為骨細胞，同時亦會釋放物質，誘導其他幹細胞演變成為與免疫系統有關的細胞。1382Please respect copyright.ＰＥＮＡＮＡDW8bBiAMGN
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缺乏Pizeo1蛋白質的老鼠當受到細菌感染的時候，所產生的免疫系統細胞數量亦明顯比擁有Pizeo1蛋白質的老鼠為少。1382Please respect copyright.ＰＥＮＡＮＡ2IQ0NooqSU
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而除運動外，歲數亦會影響與免疫系統有關的幹細胞數量，18個月大的老鼠其數量明顯少於2個月大的老鼠。1382Please respect copyright.ＰＥＮＡＮＡxAtspxaIFA
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若人類亦是採用相同機制的話，這或許是其中一道解釋運動能提升身體免疫力的理據。1382Please respect copyright.ＰＥＮＡＮＡuDaPlQvQbE
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1382Please respect copyright.ＰＥＮＡＮＡP8DEsj3Z8q
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Ref1:https://www.nature.com/articles/s41586-021-03298-51382Please respect copyright.ＰＥＮＡＮＡkzFjbuVIbn
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