科普專欄–薯不揀單 - 三十秒科學–降膽固醇藥

油並無法容易溶於水裡，因此當脂肪從我們身體的血液循環系統時，便需要依靠蛋白質的輔助，合體成為脂蛋白(Lipoprotein)，才能方便於血液中流動行走。821Please respect copyright.ＰＥＮＡＮＡhvjhVWE8Q8
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（圖2）根據密度及體積，脂蛋白可分成為不同種類。821Please respect copyright.ＰＥＮＡＮＡfJm7sEFXVT
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Low Density Lipoprotein(LDL)主要負責從肝臟把油脂傳送到各器官，而血液LDL含量長期高企的話，患上心臟病或中風的機會亦會高企，因此經常被冠稱為壞膽固醇。821Please respect copyright.ＰＥＮＡＮＡr89KM1PQGX
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而當細胞尤其是肝臟細胞內的膽固醇過多的話，便會以High Density Lipoprotein(HDL)的形式排出細胞外。821Please respect copyright.ＰＥＮＡＮＡMqB39XOdKH
細胞內含有過多膽固醇的話便會觸發細胞進行死亡的機制，基於HDL能把它們帶出細胞外，避免壞事發生，因此亦被稱之為好膽固醇。821Please respect copyright.ＰＥＮＡＮＡ1SWlGh6UpK
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（圖3）細胞可從外間直接攝取膽固醇，又或者是從其他原料自行製作膽固醇。821Please respect copyright.ＰＥＮＡＮＡpZ2GMjHeUL
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降膽固醇藥Statin能夠抑制其中一隻參與製作膽固醇過程的酶素，導致膽固醇的製作無法順利完成。821Please respect copyright.ＰＥＮＡＮＡr4VTcxwjuu
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而細胞在藥物的誤導下，以為是自己因為吸收不足夠的LDL，所以無法製作膽固醇，因此便會增大吸收外間LDL的能力，得出的結果就是把血液裡的壞膽固醇含量大幅度下降。821Please respect copyright.ＰＥＮＡＮＡq5Swdnbnzl
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能降低血液LDL含量固然是一件好事，畢竟血液LDL含量與心臟病中風等疾病有著密切的關聯。821Please respect copyright.ＰＥＮＡＮＡ6yYfReGjYu
但亦有一些統計數據指出服用Statin會增加患癌風險，其機制現時尚未能搞得清楚。821Please respect copyright.ＰＥＮＡＮＡSJtCX48mWH
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Statin藥物所抑制的製作膽固醇的機制，箇中亦包含其他有用的有機物及代謝物製作。821Please respect copyright.ＰＥＮＡＮＡZEhrH8cJLJ
干涉到那些有機物的製作會否促成癌症生長，還需要大量的研究作出探討。821Please respect copyright.ＰＥＮＡＮＡE4jFzvrXkO
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。821Please respect copyright.ＰＥＮＡＮＡNhuUPeZjZC
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc821Please respect copyright.ＰＥＮＡＮＡeQlhNPQZgw
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。821Please respect copyright.ＰＥＮＡＮＡiSU5arvoMH
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Link:821Please respect copyright.ＰＥＮＡＮＡC846ytCbUY
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio821Please respect copyright.ＰＥＮＡＮＡTPzyGlaUId
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除非Facebook及IG重開侵侵的account，否則我的IG將不會再作更新，只會寄居本土LIHKG及Penana。821Please respect copyright.ＰＥＮＡＮＡAUa576qDpE
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Ref1:https://pubmed.ncbi.nlm.nih.gov/8561503/821Please respect copyright.ＰＥＮＡＮＡyOkBabvrOK
Ref2:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225778/821Please respect copyright.ＰＥＮＡＮＡwTFFmei2k2

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