科普專欄–薯不揀單 - 三十秒科學–中國武肺(Cansino)疫苗與牛津疫苗的方別

國藥及科興是中國兩款滅活病毒疫苗。而科興數據其可信性之高，就連公開聲稱戴口罩便沒法說話的梁卓偉院長也怕怕唔敢打。630Please respect copyright.ＰＥＮＡＮＡAlzsT2D1GJ
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大概是因為中國頭兩款疫苗過於「聲名大噪」，其第三款疫苗康希諾疫苗的關注度則相對較為低。而事實上，康希諾(Cansino)的疫苗設計其實是跟牛津疫苗非常相似。630Please respect copyright.ＰＥＮＡＮＡfTefR5zwoL
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(圖2)圖中為康希諾及牛津疫苗兩款疫苗的扼要原理。630Please respect copyright.ＰＥＮＡＮＡUnzVmPkX3d
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1.疫苗的主要成份為已被削弱複製能力且無害的病毒，內含武肺S蛋白的DNA資訊。630Please respect copyright.ＰＥＮＡＮＡ3NMPDn9xlu
2. 病毒進入人體細胞。630Please respect copyright.ＰＥＮＡＮＡPTqVkz6e4j
3. 人體細胞利用病毒內含的武肺S蛋白DNA資訊，製作武肺S蛋白。630Please respect copyright.ＰＥＮＡＮＡT5vIDypKCj
4.免疫系統的相關細胞辨認武肺S蛋白是為外來之物，因而製作相應的抗體。630Please respect copyright.ＰＥＮＡＮＡiQz8sA6QqG
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（圖3）因為康希諾疫苗所用的是人類常見的感冒病毒，約4-6成的人早已擁有對抗這感冒病毒的抗體，因此病毒還沒能進入細胞之前（圖2的步驟2），便早已被自身的抗體攔截。630Please respect copyright.ＰＥＮＡＮＡrViLw8wdWX
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而牛津所用的是黑猩猩所搵到的感冒病毒，原理上人體並沒有對應的抗體，因此亦相對上更易進入細胞。630Please respect copyright.ＰＥＮＡＮＡCn7LTcERp8
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以這方面來看，牛津疫苗的設計比康希諾技勝一籌。630Please respect copyright.ＰＥＮＡＮＡOmwd7Uj5f3
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最近Bloomberg (Ref3)表示Cansino疫苗的保護效率達65.7%，而它跟Johnson&Johnson的疫苗一樣，均是一次性的方式注射。630Please respect copyright.ＰＥＮＡＮＡrYsAmejQdw
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延伸閱讀:630Please respect copyright.ＰＥＮＡＮＡwWKI0u9aaV
深入淺出–林鄭注射輝瑞/科興疫苗的最壞後果630Please respect copyright.ＰＥＮＡＮＡoY9cFlLYIl
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。630Please respect copyright.ＰＥＮＡＮＡXfOiCl4oG8
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Ref1:https://science.sciencemag.org/content/370/6522/1263630Please respect copyright.ＰＥＮＡＮＡrg3njcjqEv
Ref2:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067905/630Please respect copyright.ＰＥＮＡＮＡLMgTcSXhuS
Ref3:https://www.bloomberg.com/news/articles/2021-02-08/pakistan-says-cansino-s-covid-vaccine-shows-65-7-efficacy630Please respect copyright.ＰＥＮＡＮＡKrY1W0kgq7

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