科普專欄–薯不揀單 - 三十秒科學–中國武肺(Cansino)疫苗與牛津疫苗的方別

國藥及科興是中國兩款滅活病毒疫苗。而科興數據其可信性之高，就連公開聲稱戴口罩便沒法說話的梁卓偉院長也怕怕唔敢打。597Please respect copyright.ＰＥＮＡＮＡP09TYTRBav
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大概是因為中國頭兩款疫苗過於「聲名大噪」，其第三款疫苗康希諾疫苗的關注度則相對較為低。而事實上，康希諾(Cansino)的疫苗設計其實是跟牛津疫苗非常相似。597Please respect copyright.ＰＥＮＡＮＡegfu7W9GmK
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(圖2)圖中為康希諾及牛津疫苗兩款疫苗的扼要原理。597Please respect copyright.ＰＥＮＡＮＡB4y4aJsR4K
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1.疫苗的主要成份為已被削弱複製能力且無害的病毒，內含武肺S蛋白的DNA資訊。597Please respect copyright.ＰＥＮＡＮＡVSQYmC0LxO
2. 病毒進入人體細胞。597Please respect copyright.ＰＥＮＡＮＡ5eWePZ3D6A
3. 人體細胞利用病毒內含的武肺S蛋白DNA資訊，製作武肺S蛋白。597Please respect copyright.ＰＥＮＡＮＡA9a7Uxxi4C
4.免疫系統的相關細胞辨認武肺S蛋白是為外來之物，因而製作相應的抗體。597Please respect copyright.ＰＥＮＡＮＡaqazzA8vfi
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（圖3）因為康希諾疫苗所用的是人類常見的感冒病毒，約4-6成的人早已擁有對抗這感冒病毒的抗體，因此病毒還沒能進入細胞之前（圖2的步驟2），便早已被自身的抗體攔截。597Please respect copyright.ＰＥＮＡＮＡIfRVcNRAMu
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而牛津所用的是黑猩猩所搵到的感冒病毒，原理上人體並沒有對應的抗體，因此亦相對上更易進入細胞。597Please respect copyright.ＰＥＮＡＮＡYEAzUQqo3M
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以這方面來看，牛津疫苗的設計比康希諾技勝一籌。597Please respect copyright.ＰＥＮＡＮＡYzgaIh7hS5
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最近Bloomberg (Ref3)表示Cansino疫苗的保護效率達65.7%，而它跟Johnson&Johnson的疫苗一樣，均是一次性的方式注射。597Please respect copyright.ＰＥＮＡＮＡrKtp8kblW1
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延伸閱讀:597Please respect copyright.ＰＥＮＡＮＡv8EZY8w0rf
深入淺出–林鄭注射輝瑞/科興疫苗的最壞後果597Please respect copyright.ＰＥＮＡＮＡD1bYHzFI19
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。597Please respect copyright.ＰＥＮＡＮＡw3weAp3tMf
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc597Please respect copyright.ＰＥＮＡＮＡuXG7VHaz0e
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。597Please respect copyright.ＰＥＮＡＮＡvZMcxt3fZc
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Link:597Please respect copyright.ＰＥＮＡＮＡSILGqRew4T
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Ref1:https://science.sciencemag.org/content/370/6522/1263597Please respect copyright.ＰＥＮＡＮＡugAvKCIG2Z
Ref2:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067905/597Please respect copyright.ＰＥＮＡＮＡ8g8uSSvwxV
Ref3:https://www.bloomberg.com/news/articles/2021-02-08/pakistan-says-cansino-s-covid-vaccine-shows-65-7-efficacy597Please respect copyright.ＰＥＮＡＮＡJT4eSjGgU8

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