科普專欄–薯不揀單 - 三十秒科學–癌症所導致的體重流失

不少的癌症病人均會出現體重及BMI急速下降的情況，肌肉會出現萎縮，脂肪組織亦有機會有所消耗，這現象稱之為Cancer-associated cachexia(CAC)。547Please respect copyright.ＰＥＮＡＮＡqzj2G5e4e0
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與厭食症不同的是，體重的流失並沒能依靠增加進食來進行完全填補。547Please respect copyright.ＰＥＮＡＮＡbn5MckL3az
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（圖2）CAC的形成，是腫瘤與身體多種器官互動後所得出的結果，箇中涉及新陳代謝及荷爾蒙的轉變。547Please respect copyright.ＰＥＮＡＮＡN1UmU3ByRa
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（圖3）從圖中所見，老鼠出現腫瘤約21日後，腿部肌肉出現萎縮，與人類的CAC現象吻合。547Please respect copyright.ＰＥＮＡＮＡRxSZl4JfCk
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PTHrP是一種某類型的腫瘤釋放到血管的蛋白質，而往老鼠注射PTHrP蛋白質抗體的話，肌肉的萎縮程度亦有所緩和。547Please respect copyright.ＰＥＮＡＮＡ8U7mJxBlji
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只可是，往健康老鼠注射PTHrP蛋白質的話，肌肉並不會貿然萎縮，而往出現腫瘤的老鼠注射PTHrP蛋白質的話，肌肉萎縮的程度反會更加劇烈。547Please respect copyright.ＰＥＮＡＮＡc5yvvGK5W2
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這亦證明，PTHrP蛋白質只是導致癌症時候肌肉萎縮的其中一道組件，還需要癌細胞另外的付出才可達成。547Please respect copyright.ＰＥＮＡＮＡ9p0k54b9Ip
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癌症所帶來的CAC現象，會導致藥物對其他正常器官出現更強烈的副作用及毒性。這變相需要降低用藥的劑量作出配合，因而減低了滅癌的效率。547Please respect copyright.ＰＥＮＡＮＡiV5xYbgEAz
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因此，現今科學家亦在努力嘗試找出CAC的整套機制，務求找出有效的醫學方法制止CAC的產生。547Please respect copyright.ＰＥＮＡＮＡzxs1zKkpwE
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。547Please respect copyright.ＰＥＮＡＮＡLVhX41PuZR
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc547Please respect copyright.ＰＥＮＡＮＡRMxohu31b9
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。547Please respect copyright.ＰＥＮＡＮＡw9KAMJqaNp
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Link:547Please respect copyright.ＰＥＮＡＮＡZWfR6n0ryt
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio547Please respect copyright.ＰＥＮＡＮＡnFxut9G6bc
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基於WhatsApp/Facebook等問題，IG將不會再作更新，只會寄居本土LIHKG及Penana。547Please respect copyright.ＰＥＮＡＮＡztvAbhSZBJ
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Ref1:https://www.nature.com/articles/nature13528547Please respect copyright.ＰＥＮＡＮＡumxqkflkY3

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