科普專欄–薯不揀單 - 三十秒科學–化療效果參差的其中一道原因

化療殺滅癌細胞的效率非常參差，有些情況更反而會導致癌細胞加速生長，究竟為何會這樣?601Please respect copyright.ＰＥＮＡＮＡnnPrMvM5ge
601Please respect copyright.ＰＥＮＡＮＡEruk2PIu8v
601Please respect copyright.ＰＥＮＡＮＡN9aG1NFZrz
（圖2）使用化療藥物過後，某些癌細胞的確是會歸西死亡。601Please respect copyright.ＰＥＮＡＮＡ57o7u6hq9I
而細胞死亡的方式有好幾種，其中兩種為Apoptosis及Necrosis。601Please respect copyright.ＰＥＮＡＮＡDOcT4Lq7Ea
601Please respect copyright.ＰＥＮＡＮＡDxZqEPr1O7
601Please respect copyright.ＰＥＮＡＮＡpPT4H78xdd
如圖中所見，進行Apoptosis的細胞會呈完整球狀，屍體相對的體積較大。601Please respect copyright.ＰＥＮＡＮＡfqlMLD36pj
而進行Necrosis的細胞則會分成為不規則的碎塊，體積亦較細。601Please respect copyright.ＰＥＮＡＮＡv6wFqq5ZTT
601Please respect copyright.ＰＥＮＡＮＡygp0s2YilG
（圖3）形象化來說，Apoptosis就是曲奇餅，而Necrosis就是曲奇餅碎。601Please respect copyright.ＰＥＮＡＮＡu9JyB2na1Z
601Please respect copyright.ＰＥＮＡＮＡK6W76ctdQ4
601Please respect copyright.ＰＥＮＡＮＡoJXnqKrngJ
601Please respect copyright.ＰＥＮＡＮＡ6UMSfsI9Jy
（圖4）癌細胞被化療藥物殺死後，若進行Necrosis，鄰近沒受化療影響的癌細胞便會啟動一道名為Macropinocytosis的機制，將死亡的細胞吞噬，作營養供用使自己繼續成長，抵禦化療藥物所帶來的困境。601Please respect copyright.ＰＥＮＡＮＡ5dvZwDGBQ9
601Please respect copyright.ＰＥＮＡＮＡhcumKdipPz
601Please respect copyright.ＰＥＮＡＮＡldKy3vLpM4
但細胞進行Apoptosis的話，因屍體體積過大，鄰近的細胞便不能把其吞噬。601Please respect copyright.ＰＥＮＡＮＡALxXsbMdA0
601Please respect copyright.ＰＥＮＡＮＡaSRk8enwsb
並不是所有癌細胞亦能懂得施展Macropinocytosis，而整個機制學界亦在模索之中，只知道某些基因如PI3K或Ras進行突變的話，Macropinocytosis發生的機率亦會較大。601Please respect copyright.ＰＥＮＡＮＡfoHt8O98jw
601Please respect copyright.ＰＥＮＡＮＡYEnjYPOweT
若能掌握整套機制及研發藥物制止Macropinocytosis的發生，並在化療藥物其間同時使用，便能壓抑癌細胞吞噬死亡細胞的機制，大大增加化療的效果。601Please respect copyright.ＰＥＮＡＮＡs2IFfG7IiV
601Please respect copyright.ＰＥＮＡＮＡ7DNfct3nu1
601Please respect copyright.ＰＥＮＡＮＡnNnuWtVk2y
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。601Please respect copyright.ＰＥＮＡＮＡJ6QDZNp84V
601Please respect copyright.ＰＥＮＡＮＡD6GKXeEy5i
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc601Please respect copyright.ＰＥＮＡＮＡdwZvW4wCN5
601Please respect copyright.ＰＥＮＡＮＡQLxL455gIa
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。601Please respect copyright.ＰＥＮＡＮＡlxXdFaEW32
601Please respect copyright.ＰＥＮＡＮＡQ5diEZBjuE
Link:601Please respect copyright.ＰＥＮＡＮＡ5rsGb1EnQA
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio601Please respect copyright.ＰＥＮＡＮＡiVqgMyM3Wm
601Please respect copyright.ＰＥＮＡＮＡJrS76pU7cs
601Please respect copyright.ＰＥＮＡＮＡzP0zy8MTic
基於WhatsApp/Facebook等問題，IG將不會再作更新，只會寄居本土LIHKG及Penana。601Please respect copyright.ＰＥＮＡＮＡHAh2vlW0xr
601Please respect copyright.ＰＥＮＡＮＡz9V1g9gsuu
Ref1:https://www.nature.com/articles/s41467-020-14928-3601Please respect copyright.ＰＥＮＡＮＡ7UAw4zuNdU

ns216.73.216.248da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章