科普專欄–薯不揀單 - 三十秒科學–化療效果參差的其中一道原因

化療殺滅癌細胞的效率非常參差，有些情況更反而會導致癌細胞加速生長，究竟為何會這樣?546Please respect copyright.ＰＥＮＡＮＡKiOyPkhL8m
546Please respect copyright.ＰＥＮＡＮＡY8woePR4HG
546Please respect copyright.ＰＥＮＡＮＡgeSAmdco6P
（圖2）使用化療藥物過後，某些癌細胞的確是會歸西死亡。546Please respect copyright.ＰＥＮＡＮＡ3iypLsi6mm
而細胞死亡的方式有好幾種，其中兩種為Apoptosis及Necrosis。546Please respect copyright.ＰＥＮＡＮＡpytnUmV2ee
546Please respect copyright.ＰＥＮＡＮＡgsxl1taCOJ
546Please respect copyright.ＰＥＮＡＮＡ1qDJ7bzpSl
如圖中所見，進行Apoptosis的細胞會呈完整球狀，屍體相對的體積較大。546Please respect copyright.ＰＥＮＡＮＡ6i5MU1r3uB
而進行Necrosis的細胞則會分成為不規則的碎塊，體積亦較細。546Please respect copyright.ＰＥＮＡＮＡicQqboYrtI
546Please respect copyright.ＰＥＮＡＮＡcyCEiLze2f
（圖3）形象化來說，Apoptosis就是曲奇餅，而Necrosis就是曲奇餅碎。546Please respect copyright.ＰＥＮＡＮＡOaK5VYC1RK
546Please respect copyright.ＰＥＮＡＮＡBoyEwnO1Zs
546Please respect copyright.ＰＥＮＡＮＡRswZaz5GV7
546Please respect copyright.ＰＥＮＡＮＡgCfnc5OJhW
（圖4）癌細胞被化療藥物殺死後，若進行Necrosis，鄰近沒受化療影響的癌細胞便會啟動一道名為Macropinocytosis的機制，將死亡的細胞吞噬，作營養供用使自己繼續成長，抵禦化療藥物所帶來的困境。546Please respect copyright.ＰＥＮＡＮＡldXhjqw17W
546Please respect copyright.ＰＥＮＡＮＡZlT3cNxhV4
546Please respect copyright.ＰＥＮＡＮＡvIBz8aL40p
但細胞進行Apoptosis的話，因屍體體積過大，鄰近的細胞便不能把其吞噬。546Please respect copyright.ＰＥＮＡＮＡ1f0x3BnMLr
546Please respect copyright.ＰＥＮＡＮＡGNnNIVitqX
並不是所有癌細胞亦能懂得施展Macropinocytosis，而整個機制學界亦在模索之中，只知道某些基因如PI3K或Ras進行突變的話，Macropinocytosis發生的機率亦會較大。546Please respect copyright.ＰＥＮＡＮＡkTGNDz2rsh
546Please respect copyright.ＰＥＮＡＮＡloB9a2wTJD
若能掌握整套機制及研發藥物制止Macropinocytosis的發生，並在化療藥物其間同時使用，便能壓抑癌細胞吞噬死亡細胞的機制，大大增加化療的效果。546Please respect copyright.ＰＥＮＡＮＡILb9Q4KiFh
546Please respect copyright.ＰＥＮＡＮＡ5Kpvm6MyM9
546Please respect copyright.ＰＥＮＡＮＡsLGXwkXJTi
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。546Please respect copyright.ＰＥＮＡＮＡvNQo71bwcW
546Please respect copyright.ＰＥＮＡＮＡuESGVX8v1V
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc546Please respect copyright.ＰＥＮＡＮＡzsaJl4Xruh
546Please respect copyright.ＰＥＮＡＮＡfXz0EtqtHA
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。546Please respect copyright.ＰＥＮＡＮＡM3uGfEr6A9
546Please respect copyright.ＰＥＮＡＮＡR5W5CK3uqf
Link:546Please respect copyright.ＰＥＮＡＮＡvq5PK8Vq2m
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio546Please respect copyright.ＰＥＮＡＮＡCuYE5s3qdQ
546Please respect copyright.ＰＥＮＡＮＡKTVbDMHyKA
546Please respect copyright.ＰＥＮＡＮＡOUe9Nrq6oa
基於WhatsApp/Facebook等問題，IG將不會再作更新，只會寄居本土LIHKG及Penana。546Please respect copyright.ＰＥＮＡＮＡDTRX6lZDkL
546Please respect copyright.ＰＥＮＡＮＡpNgv2nzMgP
Ref1:https://www.nature.com/articles/s41467-020-14928-3546Please respect copyright.ＰＥＮＡＮＡyxooWGmv0T

ns216.73.216.151da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章