科普專欄–薯不揀單 - 三十秒科學–化療效果參差的其中一道原因

化療殺滅癌細胞的效率非常參差，有些情況更反而會導致癌細胞加速生長，究竟為何會這樣?611Please respect copyright.ＰＥＮＡＮＡNebWYDfOoC
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（圖2）使用化療藥物過後，某些癌細胞的確是會歸西死亡。611Please respect copyright.ＰＥＮＡＮＡujTJHutGMF
而細胞死亡的方式有好幾種，其中兩種為Apoptosis及Necrosis。611Please respect copyright.ＰＥＮＡＮＡeAl2kfV9Mq
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如圖中所見，進行Apoptosis的細胞會呈完整球狀，屍體相對的體積較大。611Please respect copyright.ＰＥＮＡＮＡUsV28jKq6r
而進行Necrosis的細胞則會分成為不規則的碎塊，體積亦較細。611Please respect copyright.ＰＥＮＡＮＡyhnUcPQO1J
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（圖3）形象化來說，Apoptosis就是曲奇餅，而Necrosis就是曲奇餅碎。611Please respect copyright.ＰＥＮＡＮＡt5vaDlEA2M
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（圖4）癌細胞被化療藥物殺死後，若進行Necrosis，鄰近沒受化療影響的癌細胞便會啟動一道名為Macropinocytosis的機制，將死亡的細胞吞噬，作營養供用使自己繼續成長，抵禦化療藥物所帶來的困境。611Please respect copyright.ＰＥＮＡＮＡ6da7hCkpQQ
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但細胞進行Apoptosis的話，因屍體體積過大，鄰近的細胞便不能把其吞噬。611Please respect copyright.ＰＥＮＡＮＡeBAWESg2OB
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並不是所有癌細胞亦能懂得施展Macropinocytosis，而整個機制學界亦在模索之中，只知道某些基因如PI3K或Ras進行突變的話，Macropinocytosis發生的機率亦會較大。611Please respect copyright.ＰＥＮＡＮＡWM0PhVEWEn
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若能掌握整套機制及研發藥物制止Macropinocytosis的發生，並在化療藥物其間同時使用，便能壓抑癌細胞吞噬死亡細胞的機制，大大增加化療的效果。611Please respect copyright.ＰＥＮＡＮＡKZFNCzhZ5r
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。611Please respect copyright.ＰＥＮＡＮＡe6wLr8lPcY
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc611Please respect copyright.ＰＥＮＡＮＡQmmMhNN9Xo
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。611Please respect copyright.ＰＥＮＡＮＡKUUwxtN9Sy
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Link:611Please respect copyright.ＰＥＮＡＮＡKmaxGJRJro
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio611Please respect copyright.ＰＥＮＡＮＡr1oXQwpDLV
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基於WhatsApp/Facebook等問題，IG將不會再作更新，只會寄居本土LIHKG及Penana。611Please respect copyright.ＰＥＮＡＮＡkHpLwzgrEB
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Ref1:https://www.nature.com/articles/s41467-020-14928-3611Please respect copyright.ＰＥＮＡＮＡsNwJnel8eV

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