化療殺滅癌細胞的效率非常參差,有些情況更反而會導致癌細胞加速生長,究竟為何會這樣?573Please respect copyright.PENANAy0KvAcRrWX573Please respect copyright.PENANA6loVMxvjV3
573Please respect copyright.PENANAgqGOh33GmJ
(圖2)使用化療藥物過後,某些癌細胞的確是會歸西死亡。573Please respect copyright.PENANAdFofbg4KG3
而細胞死亡的方式有好幾種,其中兩種為Apoptosis及Necrosis。573Please respect copyright.PENANAE1kaun7LAq573Please respect copyright.PENANA4ekMla3SVP
573Please respect copyright.PENANAPSBZJgocl5
如圖中所見,進行Apoptosis的細胞會呈完整球狀,屍體相對的體積較大。573Please respect copyright.PENANA4M0DVJvTtz
而進行Necrosis的細胞則會分成為不規則的碎塊,體積亦較細。573Please respect copyright.PENANA6YtBu9zhIN
573Please respect copyright.PENANAUXqSeZmuxc
(圖3)形象化來說,Apoptosis就是曲奇餅,而Necrosis就是曲奇餅碎。573Please respect copyright.PENANA7kimJHv9h3573Please respect copyright.PENANAfRuvuGHPQM
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(圖4)癌細胞被化療藥物殺死後,若進行Necrosis,鄰近沒受化療影響的癌細胞便會啟動一道名為Macropinocytosis的機制,將死亡的細胞吞噬,作營養供用使自己繼續成長,抵禦化療藥物所帶來的困境。573Please respect copyright.PENANAWm47GZZvjx573Please respect copyright.PENANAM4eM6opfW9
573Please respect copyright.PENANA3HQRgNgYoA
但細胞進行Apoptosis的話,因屍體體積過大,鄰近的細胞便不能把其吞噬。573Please respect copyright.PENANAWwS4j8xtD2
573Please respect copyright.PENANA7efpqRfzhD
並不是所有癌細胞亦能懂得施展Macropinocytosis,而整個機制學界亦在模索之中,只知道某些基因如PI3K或Ras進行突變的話,Macropinocytosis發生的機率亦會較大。573Please respect copyright.PENANAnugBJJCUdY
573Please respect copyright.PENANAj1tkR1e6FP
若能掌握整套機制及研發藥物制止Macropinocytosis的發生,並在化療藥物其間同時使用,便能壓抑癌細胞吞噬死亡細胞的機制,大大增加化療的效果。573Please respect copyright.PENANAzClJhOwejM
573Please respect copyright.PENANAUHKVFFNKsZ
573Please respect copyright.PENANAumugDarH2S
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。573Please respect copyright.PENANAtY7JJz4HcM
573Please respect copyright.PENANA3AGMY4vgUw
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc573Please respect copyright.PENANALsu0RIMiXh
573Please respect copyright.PENANAOcDpHDmiED
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。573Please respect copyright.PENANAZFqpHH9yqN
573Please respect copyright.PENANAjAAP3uQHLb
Link:573Please respect copyright.PENANA9u7Qp2AafK
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio573Please respect copyright.PENANAiKgFf5ZqzS
573Please respect copyright.PENANAl5lwH8BPzp
573Please respect copyright.PENANAw0VD8554CH
基於WhatsApp/Facebook等問題,IG將不會再作更新,只會寄居本土LIHKG及Penana。573Please respect copyright.PENANABLSbnqULSg
573Please respect copyright.PENANAJgGQdX1vFc
Ref1:https://www.nature.com/articles/s41467-020-14928-3573Please respect copyright.PENANAptVzC3CU7y
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薯仔聞茱莉

篇 #143
三十秒科學–化療效果參差的其中一道原因
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