科普專欄–薯不揀單 - 三十秒科學–蛇齋餅糉

癌細胞逃避免疫細胞追殺的手段何其之多，除了較早前提及的PD1/PD1L手段之外，他們亦會用上民建聯蛇齋餅糉的手段應對免疫細胞。446Please respect copyright.ＰＥＮＡＮＡSFlG5wK4zS
446Please respect copyright.ＰＥＮＡＮＡ3C6jtzkvqH
446Please respect copyright.ＰＥＮＡＮＡbCmfAYV4oW
PD1/PD1L手段:https://lih.kg/gzGnLS446Please respect copyright.ＰＥＮＡＮＡ51YMX3H0Hj
446Please respect copyright.ＰＥＮＡＮＡVpo592GyvE
446Please respect copyright.ＰＥＮＡＮＡdvuxjYcQgq
（圖2）癌細胞(尤其是腦癌)會表達大量的TDO蛋白酶，TDO蛋白酶會將從外來吸取的氨基酸Tryptophan代謝成為Kynureine;446Please respect copyright.ＰＥＮＡＮＡ0AYnGPUgZ0
整個代謝過程是在癌細胞的內部發生。446Please respect copyright.ＰＥＮＡＮＡcbLF7l9W2B
446Please respect copyright.ＰＥＮＡＮＡpjDm42AORK
446Please respect copyright.ＰＥＮＡＮＡ3uCRsbfFaF
（圖3）癌細胞可以自用Kynurenine來觸發AhR蛋白質，輔助自己的生長。446Please respect copyright.ＰＥＮＡＮＡcpOOBt6yPe

446Please respect copyright.ＰＥＮＡＮＡjGCd3bQDYW
同時間，癌細胞亦可將Kynurenine排出四周，而當周遭的免疫細胞吸取Kynurenine後，他們殲滅癌細胞的能力便會下降。446Please respect copyright.ＰＥＮＡＮＡJf3i6kaWZp
446Please respect copyright.ＰＥＮＡＮＡhcCSBrFZk5
亦即是說，當免疫細胞獲取癌細胞所提供的蛇齋餅糉（Kynurenine）後，隨之便會被成功收買，不再侵襲癌細胞。446Please respect copyright.ＰＥＮＡＮＡMZ7GcGJLgK
446Please respect copyright.ＰＥＮＡＮＡ1nAU03WUhI
（圖4）除Kynurenine外，二噁英亦能觸發AhR蛋白質，為癌細胞締造一道美好的生存環境。446Please respect copyright.ＰＥＮＡＮＡsyAJz1xto7

446Please respect copyright.ＰＥＮＡＮＡd20b1kz2Vn
446Please respect copyright.ＰＥＮＡＮＡK6KF622BbN
現今有不少癌症藥物正試圖阻隔AhR蛋白質的觸發來消滅癌症，但亦有證據指出過度阻隔AhR蛋白質有機會反而助長癌細胞的生長，以及引發不良的過敏炎症。446Please respect copyright.ＰＥＮＡＮＡBzZUHQwVgf
446Please respect copyright.ＰＥＮＡＮＡWBYho1jYFK
除研發阻隔AhR蛋白質藥物外，亦有一道方向是研發藥物減低周遭的Kynurenine濃度，減低癌細胞弱化周遭免疫細胞的能力。446Please respect copyright.ＰＥＮＡＮＡ340vyUwYNN
446Please respect copyright.ＰＥＮＡＮＡbqFXs2BSBl
若然成功，或許能配合現有的免疫治療PD1方法加強效果，消滅癌症。446Please respect copyright.ＰＥＮＡＮＡBctJBdInJw
446Please respect copyright.ＰＥＮＡＮＡa02fvho1QJ
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。446Please respect copyright.ＰＥＮＡＮＡIjIriKmsqI
446Please respect copyright.ＰＥＮＡＮＡh8ebGJoWqE
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc446Please respect copyright.ＰＥＮＡＮＡjhnmPFrWzm
446Please respect copyright.ＰＥＮＡＮＡdCvJpjsBlQ
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。446Please respect copyright.ＰＥＮＡＮＡpBfhZBEmAT
446Please respect copyright.ＰＥＮＡＮＡOgebAw1B9h
Link:446Please respect copyright.ＰＥＮＡＮＡISXprMKGgc
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio446Please respect copyright.ＰＥＮＡＮＡpk0cTXVeRW
446Please respect copyright.ＰＥＮＡＮＡMzTsYywPgN
446Please respect copyright.ＰＥＮＡＮＡ5AJkfpC0e3
基於WhatsApp/Facebook等問題，IG將不會再作更新，只會寄居本土LIHKG及Penana。446Please respect copyright.ＰＥＮＡＮＡb9qIWq4Du1
446Please respect copyright.ＰＥＮＡＮＡbm1Btg0M82
Ref1:https://www.nature.com/articles/nature10491446Please respect copyright.ＰＥＮＡＮＡll5sFzBtzg
Ref2:https://www.sciencedirect.com/science/article/pii/S0165614717302249446Please respect copyright.ＰＥＮＡＮＡr9Z722aMTa

ns18.222.226.15da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章