透過進食,我們能夠從食物中獲取身體所需的能量。這過程亦稱之為新陳代謝。528Please respect copyright.PENANAp0XACbZkaW528Please respect copyright.PENANAhCvNxHSWWi
528Please respect copyright.PENANAGRupyEWn4Q
有無數證據顯示,癌細胞的新陳代謝與正常的細胞有著顯著的分別。528Please respect copyright.PENANARXQor8RRs2
正因如此,有不少科學家抱有一個信念,希望透過針對癌細胞的新陳代謝來抑止癌細胞的生長,甚至是達消滅癌細胞之效。528Please respect copyright.PENANA12unmpXyuu
528Please respect copyright.PENANA84KMToLgZ1
(圖2)半胱胺酸 (Cysteine)是氨基酸的一種,亦即是組成蛋白質的基本單元。528Please respect copyright.PENANAHRsYbDHzUi528Please respect copyright.PENANA6WoZPOE7dH
528Please respect copyright.PENANACugK43Ro4Q
我們可以透過直接進食來攝取Cysteine,又或者依靠肝臟將特定兩隻氨基酸(Methionine及Serine)轉化成為Cysteine供我們所用。528Please respect copyright.PENANA4N3ppikUgT
528Please respect copyright.PENANAnpafQXO6pX
有科學家嘗試從飼養癌細胞的營養液中剔除Cysteine,發覺部份癌細胞的生長速度有所減慢,而有部份的癌細胞則趨向死亡(Ref1)。528Please respect copyright.PENANAfs3Ef5hdEv
528Please respect copyright.PENANAvE3YQ8LzwL
(圖3)從營養液剔除Cysteine後,身體攝取Cysteine的辦法便只剩下依靠肝臟將同為氨基酸的Methionine及Serine轉化成為Cysteine。528Please respect copyright.PENANAGGSfyiRD6G528Please respect copyright.PENANAnKcgwLczVx
528Please respect copyright.PENANA009jrvKFA1
而各種剔除Cysteine便會死亡的癌細胞的共通點,就是缺乏一隻名為5-methylthioadenosine phosphorylase(MTAP)的蛋白酶。528Please respect copyright.PENANAkNwEMMlbzZ
528Please respect copyright.PENANA0fmwsxyKOQ
失去MTAP後,細胞會傾向將Methionine轉化成為一系列名為Polyamine的物質,導致身體失去製作Cysteine的手段。528Please respect copyright.PENANAa6sUE9Z3St
528Please respect copyright.PENANAlez7RMQ0X0
更甚的是,產生Polyamine的過程中將會產生游離基,而制衡游離基的Glutathione卻則依靠Cysteine作為原材料。528Please respect copyright.PENANAtxnHdtbQSJ
528Please respect copyright.PENANA7iueTonuSP
因此,缺乏MTAP的癌細胞若然沒有外來Cysteine供應的話,便會因游離基數量過多而導致死亡。528Please respect copyright.PENANAsJTUzl0kwl
528Please respect copyright.PENANA4oIuMc11H3
環觀各種癌細胞,膠質母細胞瘤(Glioblastoma)有較大的機會因基因變異而失去MTAP基因。528Please respect copyright.PENANArSnNcGFj8K
528Please respect copyright.PENANAqgvA0UCSX2
根據上述研究結果,若癌症病人的癌細胞證實缺乏MTAP基因的話,在餐單中剔除進食Cysteine氨基酸或許是一個副作用相對上為微的理性選擇。528Please respect copyright.PENANAVCcuoWoX3N
528Please respect copyright.PENANAWLDyWO5eiT
528Please respect copyright.PENANAZkaAFbkCAn
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。528Please respect copyright.PENANAeS2OkjqlYN
528Please respect copyright.PENANAtnJhFK41Sy
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc528Please respect copyright.PENANAdJ1bkViafo
528Please respect copyright.PENANAp12bS9Abfl
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。528Please respect copyright.PENANAHgAEmOL2KA
528Please respect copyright.PENANA6gDvs7ZLs4
Link:528Please respect copyright.PENANA807pNnV6Ok
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio528Please respect copyright.PENANAEsx0wYfyrv
528Please respect copyright.PENANA2ctnW04m7J
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。528Please respect copyright.PENANAsojQlZehzK
528Please respect copyright.PENANAwY6NB44xWH
https://www.instagram.com/potatopigtongue/528Please respect copyright.PENANA0O4lLkkmYQ
528Please respect copyright.PENANApAhPW3NHLE
528Please respect copyright.PENANAGYkqlghjx8
Ref1:https://www.nature.com/articles/s42255-020-0253-2
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科普專欄–薯不揀單
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薯仔聞茱莉

篇 #127
深入淺出–針對新陳代謝來醫治癌症(一)
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