透過進食,我們能夠從食物中獲取身體所需的能量。這過程亦稱之為新陳代謝。530Please respect copyright.PENANACT9WlyELyP530Please respect copyright.PENANADWNYM6eaiT
530Please respect copyright.PENANAqrBRjG1lHo
有無數證據顯示,癌細胞的新陳代謝與正常的細胞有著顯著的分別。530Please respect copyright.PENANAd7MaNCvpcU
正因如此,有不少科學家抱有一個信念,希望透過針對癌細胞的新陳代謝來抑止癌細胞的生長,甚至是達消滅癌細胞之效。530Please respect copyright.PENANApePjKUOcqQ
530Please respect copyright.PENANAwSJZAgt7OR
(圖2)半胱胺酸 (Cysteine)是氨基酸的一種,亦即是組成蛋白質的基本單元。530Please respect copyright.PENANAziEcAGnfp2530Please respect copyright.PENANANOtcNhSsZH
530Please respect copyright.PENANA0WkCDXKVxf
我們可以透過直接進食來攝取Cysteine,又或者依靠肝臟將特定兩隻氨基酸(Methionine及Serine)轉化成為Cysteine供我們所用。530Please respect copyright.PENANATWlmr8cdxS
530Please respect copyright.PENANAo524JDIyY8
有科學家嘗試從飼養癌細胞的營養液中剔除Cysteine,發覺部份癌細胞的生長速度有所減慢,而有部份的癌細胞則趨向死亡(Ref1)。530Please respect copyright.PENANARHviDaU1D5
530Please respect copyright.PENANAMnoGNXREbP
(圖3)從營養液剔除Cysteine後,身體攝取Cysteine的辦法便只剩下依靠肝臟將同為氨基酸的Methionine及Serine轉化成為Cysteine。530Please respect copyright.PENANAXIiY3lhWTN530Please respect copyright.PENANARTmlNIYyyy
530Please respect copyright.PENANAZuk58Y4Fp9
而各種剔除Cysteine便會死亡的癌細胞的共通點,就是缺乏一隻名為5-methylthioadenosine phosphorylase(MTAP)的蛋白酶。530Please respect copyright.PENANAk6N3QdiHrS
530Please respect copyright.PENANAwwbivTuJzT
失去MTAP後,細胞會傾向將Methionine轉化成為一系列名為Polyamine的物質,導致身體失去製作Cysteine的手段。530Please respect copyright.PENANAMdYL74giLf
530Please respect copyright.PENANAefMJZe6QLZ
更甚的是,產生Polyamine的過程中將會產生游離基,而制衡游離基的Glutathione卻則依靠Cysteine作為原材料。530Please respect copyright.PENANAmWWSWmMUmZ
530Please respect copyright.PENANATTnYfloBM9
因此,缺乏MTAP的癌細胞若然沒有外來Cysteine供應的話,便會因游離基數量過多而導致死亡。530Please respect copyright.PENANAsj2iHi9Di8
530Please respect copyright.PENANASyP73HbJyK
環觀各種癌細胞,膠質母細胞瘤(Glioblastoma)有較大的機會因基因變異而失去MTAP基因。530Please respect copyright.PENANAGGDCfjwLsT
530Please respect copyright.PENANARh36IxepSF
根據上述研究結果,若癌症病人的癌細胞證實缺乏MTAP基因的話,在餐單中剔除進食Cysteine氨基酸或許是一個副作用相對上為微的理性選擇。530Please respect copyright.PENANAAaCuFPINXb
530Please respect copyright.PENANAvXQAjTNhim
530Please respect copyright.PENANAKTb2eBlMH2
如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。530Please respect copyright.PENANArLn7b5wlsa
530Please respect copyright.PENANApx1014rAaW
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc530Please respect copyright.PENANAQSr3Ccc2PM
530Please respect copyright.PENANAsYdbTBw5Uz
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。530Please respect copyright.PENANAgfMFIC3THa
530Please respect copyright.PENANAATWqv48vqa
Link:530Please respect copyright.PENANAdOGe0MElm5
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio530Please respect copyright.PENANAb3c2qsSSh6
530Please respect copyright.PENANAyQMW7VCQFl
有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。530Please respect copyright.PENANAXAhWlrCqGF
530Please respect copyright.PENANAU7iVVsXzyc
https://www.instagram.com/potatopigtongue/530Please respect copyright.PENANAo7xZIxQOjR
530Please respect copyright.PENANApOtFvQoCGU
530Please respect copyright.PENANAs4v9srHZWK
Ref1:https://www.nature.com/articles/s42255-020-0253-2
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科普專欄–薯不揀單
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薯仔聞茱莉

篇 #127
深入淺出–針對新陳代謝來醫治癌症(一)
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