科普專欄–薯不揀單 - 深入淺出–肛門塞藥的最新一道研究

肛門塞藥較會常用在兒童或不清醒的病人身上。基於大腸的表面面積非常大，而且鄰近血液循環系統，所以肝門塞藥大多時候均會比口服藥物更有效率進入血液裡頭。959Please respect copyright.ＰＥＮＡＮＡxHNJl2NgGC
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只不過最終是以口服還是肛門塞藥服用，請遵照醫生的吩咐及指示。959Please respect copyright.ＰＥＮＡＮＡbpYN4v6U4f
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（圖2）有科學家受腸道鉤蟲啟發，設計出勾狀式藥物，並發表文章匯報成果（Ref1)。959Please respect copyright.ＰＥＮＡＮＡytFCexkDlk
勾狀式藥物附上蠟質塗層，遇上體溫後便會溶化，並引致金屬制的勾爪抓緊腸道組織。959Please respect copyright.ＰＥＮＡＮＡRYVW3NMIPA
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（圖3）利用儀器以高壓方式將勾狀式藥物送進腸道位置後，藥物便會從插著腸道內的金屬爪管道排出，進入血液循環系統裡頭。959Please respect copyright.ＰＥＮＡＮＡKnYN7efdNa
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（圖4）如圖中所見，紅線為勾狀式裝置包裝藥物肛塞進入老鼠腸道，而黑線為直接將藥物肛塞進入老鼠腸道的結果。959Please respect copyright.ＰＥＮＡＮＡ0mEjyeI7n4
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利用勾狀式裝置包裝的方式送藥，藥物停留在血液的時間明顯有所增長!959Please respect copyright.ＰＥＮＡＮＡfsKmBqh32A
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而經過計算後，意欲往70kg成人輸送10mg Ketorolac的話，大概需要4900個1.5mm長的勾狀藥物。959Please respect copyright.ＰＥＮＡＮＡo5lv6kFx7k
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文中的所有研究結果均透過老鼠身上所得，能否套用在人類身上使用為未知之數。959Please respect copyright.ＰＥＮＡＮＡqjGYEhZFD9
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另一關於腸道送藥的研究，可參閱:https://www.penana.com/article/475900959Please respect copyright.ＰＥＮＡＮＡN5Z3lm61fm
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。959Please respect copyright.ＰＥＮＡＮＡNmIigCRTcm
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc959Please respect copyright.ＰＥＮＡＮＡxU3kAet6hf
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。959Please respect copyright.ＰＥＮＡＮＡZIb2vO5Nft
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio959Please respect copyright.ＰＥＮＡＮＡEgx92HoZvT
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。959Please respect copyright.ＰＥＮＡＮＡnI28a27ymn
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https://www.instagram.com/potatopigtongue/959Please respect copyright.ＰＥＮＡＮＡI5bbd5I8xg
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Ref1:https://advances.sciencemag.org/content/6/44/eabb4133959Please respect copyright.ＰＥＮＡＮＡOIbZywnp95

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