科普專欄–薯不揀單 - 深入淺出–阿斯匹靈與化療藥物並用的研究

腫瘤內有一小部份的細胞被稱之為Cancer Stem Cells(CSC)，他們對於腫瘤的發展有著莫大的功用。550Please respect copyright.ＰＥＮＡＮＡnvAQ8jPdW7
550Please respect copyright.ＰＥＮＡＮＡpAUY4KvQ7A
化療過後，大部份的癌細胞均會被殲滅，而很多時候只剩下這些CSC能夠生存；550Please respect copyright.ＰＥＮＡＮＡJgq6YUM0tY
學術界大多數會稱呼這現象為Minimal Residual Disease。550Please respect copyright.ＰＥＮＡＮＡfPX5CQGWuw
550Please respect copyright.ＰＥＮＡＮＡTfkGb9zBpv
這些一息尚存的CSC會在某一刻再度發展出新的腫瘤，而與之前腫瘤不同的是，他們會展現出抗藥性，較早前所用的化療藥物再不會對他們見效。550Please respect copyright.ＰＥＮＡＮＡYMeguuGYhX
550Please respect copyright.ＰＥＮＡＮＡ1afzZvnDKI
正因如此，現今有不少針對CSC研究一直進行中，希望可以找出辦法消滅這些CSC。550Please respect copyright.ＰＥＮＡＮＡJDrkZHhPcK
550Please respect copyright.ＰＥＮＡＮＡcf1a65ZqYB
550Please respect copyright.ＰＥＮＡＮＡmkeoGZzyUt
（圖2）CSC之所以非常之難消滅，原因就是他有各式各樣的機制躲避化療追擊，如陳同佳這天下大仆街一樣詭計多端。550Please respect copyright.ＰＥＮＡＮＡNpikjJ1JOi
550Please respect copyright.ＰＥＮＡＮＡVPCA3ILZOn
550Please respect copyright.ＰＥＮＡＮＡBSO4rESdsh
其中一例就是CSC會產生名為ABCG2的蛋白質，這些ABCG2蛋白質有著將化療藥物排出細胞體外的效果，導致化療藥物無法長期留在細胞內，大幅度失去藥效。550Please respect copyright.ＰＥＮＡＮＡ3zgyhQRHOs
550Please respect copyright.ＰＥＮＡＮＡUg2MlTAwr5
（圖3）有科學家發現（Ref1)，名為SMAR1蛋白質有抑制ABCG2產生的功效。亦即是說，SMAR1蛋白質含量越低的話，ABCG2就越容易能夠生產出來。550Please respect copyright.ＰＥＮＡＮＡMGfxLdgVen
550Please respect copyright.ＰＥＮＡＮＡBCXrclmiUa
550Please respect copyright.ＰＥＮＡＮＡ4syJ0pyiIg
550Please respect copyright.ＰＥＮＡＮＡgq00Jmnle1
550Please respect copyright.ＰＥＮＡＮＡVyLHQ6003i
而CSC內有兩隻名為OCT4及SOX2的蛋白質，他們能夠抑制SMAR1的蛋白質產生，導致ABCG2更容易產生出來，令細胞更容易將藥物排出體外。550Please respect copyright.ＰＥＮＡＮＡ2XYrvQCEIA
550Please respect copyright.ＰＥＮＡＮＡCWqRhzwafr
550Please respect copyright.ＰＥＮＡＮＡZP0xcyFta8
（圖4）尋覓已知資料一輪後，阿斯匹靈為已證實可抑制OCT4及SOX2蛋白質的藥物，同時亦不會被ABCG2有效排出。550Please respect copyright.ＰＥＮＡＮＡ169YF3Q5Nc
550Please respect copyright.ＰＥＮＡＮＡ0OoujHlhIi
550Please respect copyright.ＰＥＮＡＮＡSH6ewPxCpm
這裡無疑會產生一道詢問，若果利用阿斯匹靈抑制ABCG2的產生，同時再加上化療藥物的話，會否是殺死CSC的一道妙計呢?550Please respect copyright.ＰＥＮＡＮＡHzbF19rZem
550Please respect copyright.ＰＥＮＡＮＡ1uUiEblltm
550Please respect copyright.ＰＥＮＡＮＡiq04oXvWPw
（圖5）在老鼠實驗中，同時用上阿斯匹靈及化療藥物Doxorubicin的話，的確可以令腫瘤大幅度縮小。550Please respect copyright.ＰＥＮＡＮＡ9AuIuvSnNR
550Please respect copyright.ＰＥＮＡＮＡmfI2GszSqG
550Please respect copyright.ＰＥＮＡＮＡSwRUVeLxCE
但在這實驗中，單獨用上阿斯匹靈已能導致腫瘤縮小，而且文章亦沒有確實證據指出腫瘤縮小的原因是否因為少了CSC的緣故。550Please respect copyright.ＰＥＮＡＮＡZegnkHFrug
550Please respect copyright.ＰＥＮＡＮＡZ0g7qFhMOq
雖有理論證據在背後支持，但用上阿斯匹靈輔助化療效果的理論還需要確實的實驗結果再作進一步的證實。550Please respect copyright.ＰＥＮＡＮＡrOQrQ7wCwK
550Please respect copyright.ＰＥＮＡＮＡfNED3pInj4
550Please respect copyright.ＰＥＮＡＮＡEWtT6N7XqW
到底阿斯匹靈輔助化療效果的理論得以確實先，還是陳同住到台灣自首先呢？550Please respect copyright.ＰＥＮＡＮＡD3payxsDMe
550Please respect copyright.ＰＥＮＡＮＡ2jy5uJjzeG
答案呼之欲出！550Please respect copyright.ＰＥＮＡＮＡK5AlGffBaI
550Please respect copyright.ＰＥＮＡＮＡ6Oj4xdlzgt
550Please respect copyright.ＰＥＮＡＮＡNTLUaRSump
550Please respect copyright.ＰＥＮＡＮＡ01M2xNdiFO
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。550Please respect copyright.ＰＥＮＡＮＡt9jspkjnTw
550Please respect copyright.ＰＥＮＡＮＡ67AnbIjnkG
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc550Please respect copyright.ＰＥＮＡＮＡ77OwboVX6x
550Please respect copyright.ＰＥＮＡＮＡtuLMUjoKRV
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。550Please respect copyright.ＰＥＮＡＮＡ299lKVEIm3
550Please respect copyright.ＰＥＮＡＮＡuqAMDZIwpG
Link:550Please respect copyright.ＰＥＮＡＮＡNGWP0BwE7D
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio550Please respect copyright.ＰＥＮＡＮＡXXAqD7dCuV
550Please respect copyright.ＰＥＮＡＮＡQ6IknhafFx
550Please respect copyright.ＰＥＮＡＮＡ1p8imElugM
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。550Please respect copyright.ＰＥＮＡＮＡQIAEK6x4Tf
550Please respect copyright.ＰＥＮＡＮＡgCF9Qw6gj9
https://www.instagram.com/potatopigtongue/550Please respect copyright.ＰＥＮＡＮＡz9hLp9arc7
550Please respect copyright.ＰＥＮＡＮＡyaarfJRdxh
Ref1:https://stke.sciencemag.org/content/13/654/eaay6077550Please respect copyright.ＰＥＮＡＮＡGsARM4dt7A

ns216.73.216.216da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章