科普專欄–薯不揀單 - 深入淺出–阿斯匹靈與化療藥物並用的研究

腫瘤內有一小部份的細胞被稱之為Cancer Stem Cells(CSC)，他們對於腫瘤的發展有著莫大的功用。576Please respect copyright.ＰＥＮＡＮＡGQkAinTd9e
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化療過後，大部份的癌細胞均會被殲滅，而很多時候只剩下這些CSC能夠生存；576Please respect copyright.ＰＥＮＡＮＡ1jrnjQ0K40
學術界大多數會稱呼這現象為Minimal Residual Disease。576Please respect copyright.ＰＥＮＡＮＡVc7yUsPFCi
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這些一息尚存的CSC會在某一刻再度發展出新的腫瘤，而與之前腫瘤不同的是，他們會展現出抗藥性，較早前所用的化療藥物再不會對他們見效。576Please respect copyright.ＰＥＮＡＮＡs3oCaBZP0z
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正因如此，現今有不少針對CSC研究一直進行中，希望可以找出辦法消滅這些CSC。576Please respect copyright.ＰＥＮＡＮＡ29AjEy0N6Z
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（圖2）CSC之所以非常之難消滅，原因就是他有各式各樣的機制躲避化療追擊，如陳同佳這天下大仆街一樣詭計多端。576Please respect copyright.ＰＥＮＡＮＡYGgjiovVF3
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其中一例就是CSC會產生名為ABCG2的蛋白質，這些ABCG2蛋白質有著將化療藥物排出細胞體外的效果，導致化療藥物無法長期留在細胞內，大幅度失去藥效。576Please respect copyright.ＰＥＮＡＮＡYcVX1IhTCU
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（圖3）有科學家發現（Ref1)，名為SMAR1蛋白質有抑制ABCG2產生的功效。亦即是說，SMAR1蛋白質含量越低的話，ABCG2就越容易能夠生產出來。576Please respect copyright.ＰＥＮＡＮＡ5IGHJt4fdV
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而CSC內有兩隻名為OCT4及SOX2的蛋白質，他們能夠抑制SMAR1的蛋白質產生，導致ABCG2更容易產生出來，令細胞更容易將藥物排出體外。576Please respect copyright.ＰＥＮＡＮＡTOwqhywWwy
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（圖4）尋覓已知資料一輪後，阿斯匹靈為已證實可抑制OCT4及SOX2蛋白質的藥物，同時亦不會被ABCG2有效排出。576Please respect copyright.ＰＥＮＡＮＡKwTebRXwu7
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這裡無疑會產生一道詢問，若果利用阿斯匹靈抑制ABCG2的產生，同時再加上化療藥物的話，會否是殺死CSC的一道妙計呢?576Please respect copyright.ＰＥＮＡＮＡf2qDznQfBo
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（圖5）在老鼠實驗中，同時用上阿斯匹靈及化療藥物Doxorubicin的話，的確可以令腫瘤大幅度縮小。576Please respect copyright.ＰＥＮＡＮＡdrSZW54LJ8
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但在這實驗中，單獨用上阿斯匹靈已能導致腫瘤縮小，而且文章亦沒有確實證據指出腫瘤縮小的原因是否因為少了CSC的緣故。576Please respect copyright.ＰＥＮＡＮＡUqLGyJ6V6j
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雖有理論證據在背後支持，但用上阿斯匹靈輔助化療效果的理論還需要確實的實驗結果再作進一步的證實。576Please respect copyright.ＰＥＮＡＮＡDYU8546bKL
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到底阿斯匹靈輔助化療效果的理論得以確實先，還是陳同住到台灣自首先呢？576Please respect copyright.ＰＥＮＡＮＡTv6FkPNS4k
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答案呼之欲出！576Please respect copyright.ＰＥＮＡＮＡWR4qxtZ1vr
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。576Please respect copyright.ＰＥＮＡＮＡ6YuWy2dxpy
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Ref1:https://stke.sciencemag.org/content/13/654/eaay6077576Please respect copyright.ＰＥＮＡＮＡEKssxa58D6

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