食魚會使人變得更聰明,這句說話很大程度上可能是建基於不少魚類含有大量OMEGA3脂肪酸。644Please respect copyright.PENANARpztYEhjgT644Please respect copyright.PENANAlEHIeNjzD2
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DHA是OMEGA3脂肪酸的一種,有實驗證據(Ref1)顯示有助老鼠大腦發展,故此被推算能預防人類腦退化症的發生,又或者輾轉被認定可以使人變得更加聰明。644Please respect copyright.PENANAvD30md3acV
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無論如何,媒體廣告經常渲染DHA對人體非常有益,尤其是標榜魚肝油產品含有好多DHA,非常值得進食,這究竟可不可信呢?644Please respect copyright.PENANAGzWSEOeedT
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(圖2)基於個別某幾種蛋白酶數量不足的關係,我們的腦部只能產生極為微量的DHA,而肝臟亦只能夠產生相對少量DHA,因此DHA的獲取來源主要均依靠飲食得來。644Please respect copyright.PENANAHQx58qAKC5644Please respect copyright.PENANAVY9ETNKwuT
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但有研究發現(Ref1,2),餵飼老鼠DHA的話,血液、心臟及肝臟DHA含量雖然的確有所提高,但腦部的DHA水平則無任何大變化。644Please respect copyright.PENANASLgEu12YPq
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若然DHA無法進入腦部的話,亦沒能夠為大腦帶來正面影響。644Please respect copyright.PENANAsC3leLhBT5
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(圖3)經過一系列的研究後,科學家發現Mfsd2a是腦部負責從血管接收DHA的蛋白質(Ref3,4),它傾向接收與磷脂LPC結合的DHA,而不太傾向接納其他狀態的DHA。644Please respect copyright.PENANAjZLiLziSN3644Please respect copyright.PENANAhzOkUG2Hue
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這亦解釋得到,為何單獨餵飼老鼠DHA並不會引起腦部的DHA水平提升,原因是它並不是處於與LPC連結的狀態。644Please respect copyright.PENANAt5a9tVv2pO
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然而,這個機制僅是腦部獨有,因此心臟、肝臟以及脂肪組織均能輕易有效攝取DHA,以及與磷脂LPC結合的DHA。644Please respect copyright.PENANACVAStimmpA
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(圖4)有研究(Ref5,6)指出,DHA與磷脂LPC的sn-2位置結合的話,DHA進入腦部的效果會更好。但亦有研究(Ref1)指sn-1或者sn-2均無任何大影響。644Please respect copyright.PENANANHI8CORaeE644Please respect copyright.PENANAMj4nR3nXgX
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這些在老鼠大腦進行的研究,能否百分百套用在人類身上還是未知之數。644Please respect copyright.PENANAhizrumHy4A
但若然初心是想讓大腦攝取DHA的話,選購健康產品的時候還是留意一下究竟相應的DHA究竟是處於甚麼狀態為好。644Please respect copyright.PENANAyBa6SDuSeb
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至於日常飲食的話,磷蝦油(Krill Oil)則對比魚油相對上含有較多與磷脂結合的DHA。644Please respect copyright.PENANAgcQ8IrBBc7
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吃魚會使人變得更聰明,日後可能要改寫成為磷蝦了。644Please respect copyright.PENANAUpALWh828h
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如果想我快啲出文的話,請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark,這對我非常之重要。644Please respect copyright.PENANA3qQSx8j26R
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc644Please respect copyright.PENANAFqTrmmuG1S
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」,以課金的方式推動我繼續搜羅資料寫文,多謝。644Please respect copyright.PENANAUxcbAjdtek
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Link:644Please respect copyright.PENANAXTFYqoGH6B
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio644Please respect copyright.PENANA8yCC5FCIsF
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有興趣接收科學資訊的話,歡迎follow IG: potatopigtongue。644Please respect copyright.PENANAxdfwYRaYuW
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Ref1:https://www.nature.com/articles/s41598-017-11766-0644Please respect copyright.PENANAyESCvVcvq6
Ref2:https://www.sciencedirect.com/science/article/pii/S0098299717301358#bib304644Please respect copyright.PENANAmUFy4NzE9X
Ref3:https://www.nature.com/articles/nature13241644Please respect copyright.PENANArmxu60vVXF
Ref4:https://portlandpress.com/biochemj/article-abstract/345/1/61/34800/Characterization-of-plasma-unsaturated?redirectedFrom=fulltext644Please respect copyright.PENANATHNj73H4Yu
Ref5:https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.1992.tb08353.x644Please respect copyright.PENANAEtyqt4pn4K
Ref6:https://journals.physiology.org/doi/abs/10.1152/ajpregu.1994.267.5.R1273?casa_token=1ZAjjbsr9IUAAAAA:GSyyUhEOi025bD-GJBWZFJqa8JrLt4HV9a9z3qqxJug7nP8x9bOoPUa1xJcixYkRJWXBWQ6ohZGHhw644Please respect copyright.PENANA8RUlBkkZQt
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科普專欄–薯不揀單
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薯仔聞茱莉

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深入淺出–食魚會使人變得更聰明?
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