科普專欄–薯不揀單 - 深入淺出–食魚會使人變得更聰明?

食魚會使人變得更聰明，這句說話很大程度上可能是建基於不少魚類含有大量OMEGA3脂肪酸。686Please respect copyright.ＰＥＮＡＮＡh7YfUuPLeW
686Please respect copyright.ＰＥＮＡＮＡDyGbaK7xWK
686Please respect copyright.ＰＥＮＡＮＡ0gfuMm4anj
DHA是OMEGA3脂肪酸的一種，有實驗證據(Ref1)顯示有助老鼠大腦發展，故此被推算能預防人類腦退化症的發生，又或者輾轉被認定可以使人變得更加聰明。686Please respect copyright.ＰＥＮＡＮＡHh1uIou6x3
686Please respect copyright.ＰＥＮＡＮＡH5KBVhpA7k
無論如何，媒體廣告經常渲染DHA對人體非常有益，尤其是標榜魚肝油產品含有好多DHA，非常值得進食，這究竟可不可信呢?686Please respect copyright.ＰＥＮＡＮＡdVf9BYIeWf
686Please respect copyright.ＰＥＮＡＮＡfWBfrJIU4T
686Please respect copyright.ＰＥＮＡＮＡqRoVr7UQCh
(圖2)基於個別某幾種蛋白酶數量不足的關係，我們的腦部只能產生極為微量的DHA，而肝臟亦只能夠產生相對少量DHA，因此DHA的獲取來源主要均依靠飲食得來。686Please respect copyright.ＰＥＮＡＮＡpOWncUWzrQ
686Please respect copyright.ＰＥＮＡＮＡDBDQ4qZLqu
686Please respect copyright.ＰＥＮＡＮＡ8F5S5PZ77e
但有研究發現(Ref1,2)，餵飼老鼠DHA的話，血液、心臟及肝臟DHA含量雖然的確有所提高，但腦部的DHA水平則無任何大變化。686Please respect copyright.ＰＥＮＡＮＡ1GBrKAYBHW
686Please respect copyright.ＰＥＮＡＮＡtaOs2oFeOY
若然DHA無法進入腦部的話，亦沒能夠為大腦帶來正面影響。686Please respect copyright.ＰＥＮＡＮＡdVlwlZra3O
686Please respect copyright.ＰＥＮＡＮＡLBalrxgxsJ
（圖3）經過一系列的研究後，科學家發現Mfsd2a是腦部負責從血管接收DHA的蛋白質(Ref3,4)，它傾向接收與磷脂LPC結合的DHA，而不太傾向接納其他狀態的DHA。686Please respect copyright.ＰＥＮＡＮＡns5DZ5sz9p
686Please respect copyright.ＰＥＮＡＮＡGUUJbMk1p9
686Please respect copyright.ＰＥＮＡＮＡU2HSgufH3A
這亦解釋得到，為何單獨餵飼老鼠DHA並不會引起腦部的DHA水平提升，原因是它並不是處於與LPC連結的狀態。686Please respect copyright.ＰＥＮＡＮＡs3YdXZh1ge
686Please respect copyright.ＰＥＮＡＮＡ8cjGiqUpU2
然而，這個機制僅是腦部獨有，因此心臟、肝臟以及脂肪組織均能輕易有效攝取DHA，以及與磷脂LPC結合的DHA。686Please respect copyright.ＰＥＮＡＮＡrDZAIXIlDi
686Please respect copyright.ＰＥＮＡＮＡNafXwPfo5W
（圖4）有研究(Ref5,6)指出，DHA與磷脂LPC的sn-2位置結合的話，DHA進入腦部的效果會更好。但亦有研究(Ref1)指sn-1或者sn-2均無任何大影響。686Please respect copyright.ＰＥＮＡＮＡRAxCE1nH1r
686Please respect copyright.ＰＥＮＡＮＡyLYdoUbEXJ
686Please respect copyright.ＰＥＮＡＮＡMfcGCn3ZMC
這些在老鼠大腦進行的研究，能否百分百套用在人類身上還是未知之數。686Please respect copyright.ＰＥＮＡＮＡ0iDTX6qqqz
但若然初心是想讓大腦攝取DHA的話，選購健康產品的時候還是留意一下究竟相應的DHA究竟是處於甚麼狀態為好。686Please respect copyright.ＰＥＮＡＮＡ9G4cVQcXnX
686Please respect copyright.ＰＥＮＡＮＡlMqkJxuavA
至於日常飲食的話，磷蝦油（Krill Oil)則對比魚油相對上含有較多與磷脂結合的DHA。686Please respect copyright.ＰＥＮＡＮＡYVchR9OlJd
686Please respect copyright.ＰＥＮＡＮＡfHPKyE7Oid
吃魚會使人變得更聰明，日後可能要改寫成為磷蝦了。686Please respect copyright.ＰＥＮＡＮＡAdQBxpaMwz
686Please respect copyright.ＰＥＮＡＮＡVt2jyflfVL
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。686Please respect copyright.ＰＥＮＡＮＡJDuJshw042
686Please respect copyright.ＰＥＮＡＮＡQxPYHbJ2vU
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc686Please respect copyright.ＰＥＮＡＮＡeLHPEH0mHJ
686Please respect copyright.ＰＥＮＡＮＡlBlqzsF8AF
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。686Please respect copyright.ＰＥＮＡＮＡgGUl0GGlvD
686Please respect copyright.ＰＥＮＡＮＡrJOfVIZ1h6
Link:686Please respect copyright.ＰＥＮＡＮＡFvq1uW9i9H
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio686Please respect copyright.ＰＥＮＡＮＡvSxP5nv15J
686Please respect copyright.ＰＥＮＡＮＡHvUHtAYv0I
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。686Please respect copyright.ＰＥＮＡＮＡn3q4RlKqZ7
686Please respect copyright.ＰＥＮＡＮＡNqhTtZDi8f
Ref1:https://www.nature.com/articles/s41598-017-11766-0686Please respect copyright.ＰＥＮＡＮＡiNhR1w2DHa
Ref2:https://www.sciencedirect.com/science/article/pii/S0098299717301358#bib304686Please respect copyright.ＰＥＮＡＮＡvxtN7A6J8D
Ref3:https://www.nature.com/articles/nature13241686Please respect copyright.ＰＥＮＡＮＡqM7j1ByZ42
Ref4:https://portlandpress.com/biochemj/article-abstract/345/1/61/34800/Characterization-of-plasma-unsaturated?redirectedFrom=fulltext686Please respect copyright.ＰＥＮＡＮＡcSPgLz8BvM
Ref5:https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.1992.tb08353.x686Please respect copyright.ＰＥＮＡＮＡncO9qhklzx
Ref6:https://journals.physiology.org/doi/abs/10.1152/ajpregu.1994.267.5.R1273?casa_token=1ZAjjbsr9IUAAAAA:GSyyUhEOi025bD-GJBWZFJqa8JrLt4HV9a9z3qqxJug7nP8x9bOoPUa1xJcixYkRJWXBWQ6ohZGHhw686Please respect copyright.ＰＥＮＡＮＡz7Qn30d6r3

ns216.73.216.118da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章