科普專欄–薯不揀單 - 深入淺出–吸煙與肺癌的關係

吸煙會引致肺癌機率大幅度上升，究竟現今有沒有充分證據證明這句說話呢?530Please respect copyright.ＰＥＮＡＮＡcO3abAd01J
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（圖2）講述之前，我們快速了解一下癌症形成的概論。530Please respect copyright.ＰＥＮＡＮＡbMGzkmjiAu
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正常的細胞，裡頭擁有一系列的機制控制生長速度，確保不會出現無止境繁殖的局面。530Please respect copyright.ＰＥＮＡＮＡwK0dkmvgge
而當正常細胞的DNA發生異變的時候，大致上會迎來四個結局。530Please respect copyright.ＰＥＮＡＮＡD0kaVU1ZCg
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通常情況下，細胞會立刻修復DNA的變異，使變異細胞回復成為正常細胞。530Please respect copyright.ＰＥＮＡＮＡ9Wzzir0oe2
若果DNA修復機制失效的話，免疫細胞會辨認變異細胞為外來之物，將其殲滅以免遺禍人間。530Please respect copyright.ＰＥＮＡＮＡLvbuQKD9YT
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而如果修復DNA機制及免疫系統同時失效的話，便會有兩種可能性的發生。530Please respect copyright.ＰＥＮＡＮＡECCjZvOMiy
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假若異變DNA原本的工作是負責控制生長速度、而其變異導致自身功用失效的話，細胞便有機會不受控地自我繁殖，形成腫瘤。530Please respect copyright.ＰＥＮＡＮＡqiDGW0vxrP
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而如果異變DNA對發展癌細胞方面沒有任何幫助的話，那細胞便不會發展成為癌細胞，繼續攜帶變異DNA以正常速度繁殖。530Please respect copyright.ＰＥＮＡＮＡnI8fM9QFsl
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總言而之，DNA發生變異是正常細發展成為癌細胞的第一步。530Please respect copyright.ＰＥＮＡＮＡaozSPVWinf
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（圖3）為探討吸煙對DNA變異的影響，有研究找來對應群組（3個兒童、4個非吸煙者、6個已戒煙人士、3個尚有食煙習慣的渣滓）作檢驗(Ref1)，分別抽取各人的氣管細胞，以逐個細胞的方式檢驗DNA，以作DNA變異程度的觀察之用。530Please respect copyright.ＰＥＮＡＮＡ639FIIxo8e
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（圖4）DNA的變異有幾種方式，如圖中所見，吸煙人士的DNA變異均比非吸煙者為多頻密。530Please respect copyright.ＰＥＮＡＮＡQ6TRXDNLTI
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（圖5）而最為重要的是，吸煙人士的氣管細胞擁有更多已知會導致癌症出現的基因轉變，這一系列的資料均指出吸煙是會增加癌症出現的機會。530Please respect copyright.ＰＥＮＡＮＡE43vCuul6y
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（圖6）當然，凡事也是有例外的！530Please respect copyright.ＰＥＮＡＮＡnTPjfYVVqt
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。530Please respect copyright.ＰＥＮＡＮＡSOM0ghJFs2
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc530Please respect copyright.ＰＥＮＡＮＡfEcR8HRv4B
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。530Please respect copyright.ＰＥＮＡＮＡKVb2RmIrJE
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio530Please respect copyright.ＰＥＮＡＮＡ9lPy9ULIJi
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。530Please respect copyright.ＰＥＮＡＮＡsUsgqGgGCI
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Ref1:https://www.nature.com/articles/s41586-020-1961-1