科普專欄–薯不揀單 - 深入淺出–食魚會使人變得更聰明?

食魚會使人變得更聰明，這句說話很大程度上可能是建基於不少魚類含有大量OMEGA3脂肪酸。637Please respect copyright.ＰＥＮＡＮＡZT8yigFYna
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DHA是OMEGA3脂肪酸的一種，有實驗證據(Ref1)顯示有助老鼠大腦發展，故此被推算能預防人類腦退化症的發生，又或者輾轉被認定可以使人變得更加聰明。637Please respect copyright.ＰＥＮＡＮＡPZtCtz6Epf
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無論如何，媒體廣告經常渲染DHA對人體非常有益，尤其是標榜魚肝油產品含有好多DHA，非常值得進食，這究竟可不可信呢?637Please respect copyright.ＰＥＮＡＮＡT3cVEGjKeo
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(圖2)基於個別某幾種蛋白酶數量不足的關係，我們的腦部只能產生極為微量的DHA，而肝臟亦只能夠產生相對少量DHA，因此DHA的獲取來源主要均依靠飲食得來。637Please respect copyright.ＰＥＮＡＮＡOArDboU6fU
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但有研究發現(Ref1,2)，餵飼老鼠DHA的話，血液、心臟及肝臟DHA含量雖然的確有所提高，但腦部的DHA水平則無任何大變化。637Please respect copyright.ＰＥＮＡＮＡFGyVjX20Bg
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若然DHA無法進入腦部的話，亦沒能夠為大腦帶來正面影響。637Please respect copyright.ＰＥＮＡＮＡxUCwdXeXgh
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（圖3）經過一系列的研究後，科學家發現Mfsd2a是腦部負責從血管接收DHA的蛋白質(Ref3,4)，它傾向接收與磷脂LPC結合的DHA，而不太傾向接納其他狀態的DHA。637Please respect copyright.ＰＥＮＡＮＡgbhH4k7bc7
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這亦解釋得到，為何單獨餵飼老鼠DHA並不會引起腦部的DHA水平提升，原因是它並不是處於與LPC連結的狀態。637Please respect copyright.ＰＥＮＡＮＡBCU5TuAAjm
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然而，這個機制僅是腦部獨有，因此心臟、肝臟以及脂肪組織均能輕易有效攝取DHA，以及與磷脂LPC結合的DHA。637Please respect copyright.ＰＥＮＡＮＡOv5rWMhtSE
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（圖4）有研究(Ref5,6)指出，DHA與磷脂LPC的sn-2位置結合的話，DHA進入腦部的效果會更好。但亦有研究(Ref1)指sn-1或者sn-2均無任何大影響。637Please respect copyright.ＰＥＮＡＮＡNK5UB4Xy5d
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這些在老鼠大腦進行的研究，能否百分百套用在人類身上還是未知之數。637Please respect copyright.ＰＥＮＡＮＡlZnXLewXRb
但若然初心是想讓大腦攝取DHA的話，選購健康產品的時候還是留意一下究竟相應的DHA究竟是處於甚麼狀態為好。637Please respect copyright.ＰＥＮＡＮＡovBesYAqxy
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至於日常飲食的話，磷蝦油（Krill Oil)則對比魚油相對上含有較多與磷脂結合的DHA。637Please respect copyright.ＰＥＮＡＮＡtoslzAcGUi
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吃魚會使人變得更聰明，日後可能要改寫成為磷蝦了。637Please respect copyright.ＰＥＮＡＮＡX1fK7m2Yso
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。637Please respect copyright.ＰＥＮＡＮＡ2gyWP1hqGs
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc637Please respect copyright.ＰＥＮＡＮＡjmLkUxCECj
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。637Please respect copyright.ＰＥＮＡＮＡ9KsTJ6v5a4
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Link:637Please respect copyright.ＰＥＮＡＮＡ8N66ga1DGe
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio637Please respect copyright.ＰＥＮＡＮＡnCphZ4jkNa
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。637Please respect copyright.ＰＥＮＡＮＡEQ5ZFQQT8b
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Ref1:https://www.nature.com/articles/s41598-017-11766-0637Please respect copyright.ＰＥＮＡＮＡDMSf9KhXmt
Ref2:https://www.sciencedirect.com/science/article/pii/S0098299717301358#bib304637Please respect copyright.ＰＥＮＡＮＡbko1c1VFhe
Ref3:https://www.nature.com/articles/nature13241637Please respect copyright.ＰＥＮＡＮＡBtFDrKDK8A
Ref4:https://portlandpress.com/biochemj/article-abstract/345/1/61/34800/Characterization-of-plasma-unsaturated?redirectedFrom=fulltext637Please respect copyright.ＰＥＮＡＮＡn09v15q7ac
Ref5:https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.1992.tb08353.x637Please respect copyright.ＰＥＮＡＮＡLcsbYVzWQi
Ref6:https://journals.physiology.org/doi/abs/10.1152/ajpregu.1994.267.5.R1273?casa_token=1ZAjjbsr9IUAAAAA:GSyyUhEOi025bD-GJBWZFJqa8JrLt4HV9a9z3qqxJug7nP8x9bOoPUa1xJcixYkRJWXBWQ6ohZGHhw637Please respect copyright.ＰＥＮＡＮＡEm3ZLoeZ3s

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