科普專欄–薯不揀單 - 深入淺出–建構人造腸道厚膜的藥物

腸道是人體吸收葡萄糖的主要地方，亦是消化乳糖酵素(Lactase）的聚居地。959Please respect copyright.ＰＥＮＡＮＡ6OwlNfO4uH
缺乏Lactase的人並不建議進食含有乳糖的產品，否則會釀起肚痾、腹痛、作嘔等症狀，學名為Lactose Intolerance。959Please respect copyright.ＰＥＮＡＮＡg8GS61WZlE
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同時，腸道亦是寄生蟲的蝸居，飲用不乾淨水的話有機會讓血吸蟲寄生在腸道之中，引起血吸蟲病（Schistosomiasis)，為全球第二大僅次於瘧疾(Malaria)的寄生蟲病。959Please respect copyright.ＰＥＮＡＮＡ5zx7G3S5Ql
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（圖2）近日，有科學家發表文章（Ref1)，他們研發出一款口服藥物，主要利用豬隻作為動物模型，證實豬隻吞下藥物後的12分鐘會腸道形成厚膜。959Please respect copyright.ＰＥＮＡＮＡQP6fu6H428
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此厚膜不會在其他器官上形成，而在24小時後厚膜亦會自然脫落，排出體外。959Please respect copyright.ＰＥＮＡＮＡ5kUcnjvPU6
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（圖3）根據口服藥物的配方不同，厚膜的特性亦能隨之轉變。959Please respect copyright.ＰＥＮＡＮＡgBIEh6NIrI
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厚膜可配載消化乳糖酵素(Lactase)，對比沒有厚膜，能增強20倍酵素的能力，可消除Lactose Intolerance的問題。959Please respect copyright.ＰＥＮＡＮＡGldDjtUFj5
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而增強厚膜密度的話，亦可減少腸道吸收葡萄糖七成能力，這特點尤其受益於糖尿病人，能大幅度阻上血糖飄升。959Please respect copyright.ＰＥＮＡＮＡLf0C2fkqBk
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另外，厚膜亦可配載殺寄生蟲藥(Praziquantel)，增加藥物滯留在腸道的時間，更有效率殺滅寄生蟲。959Please respect copyright.ＰＥＮＡＮＡ6OnWJulZsI
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（圖4）最為振奮的是，此方法在人類腸道組織亦見效，而且藥物對各種實驗室人體細胞亦無呈現有害效果。959Please respect copyright.ＰＥＮＡＮＡSgfQjxNCMD
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老鼠服用藥物28日後，體重血壓等一切正常。959Please respect copyright.ＰＥＮＡＮＡl0Mrxye5vC
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若然此藥物能進一步在人類進行試驗的話，確立藥物運作正常及不會帶來任何副作用或安全問題的話，絕對大有潛質會成為治理糖尿病的新一代藥物。959Please respect copyright.ＰＥＮＡＮＡmVoLW7ruWY
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。959Please respect copyright.ＰＥＮＡＮＡNUhni8aAqf
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Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc959Please respect copyright.ＰＥＮＡＮＡBXdwGAuh2H
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同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。959Please respect copyright.ＰＥＮＡＮＡ6KOi7lSiff
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https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio959Please respect copyright.ＰＥＮＡＮＡAoOjqTHMr8
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有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。959Please respect copyright.ＰＥＮＡＮＡgJ7IghVwdZ
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Ref1:https://stm.sciencemag.org/content/12/558/eabc0441

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