科普專欄–薯不揀單 - 深入淺出–建構人造腸道厚膜的藥物

腸道是人體吸收葡萄糖的主要地方，亦是消化乳糖酵素(Lactase）的聚居地。1056Please respect copyright.ＰＥＮＡＮＡ9C7VjALCgj
缺乏Lactase的人並不建議進食含有乳糖的產品，否則會釀起肚痾、腹痛、作嘔等症狀，學名為Lactose Intolerance。1056Please respect copyright.ＰＥＮＡＮＡ4zGimoq8X7
1056Please respect copyright.ＰＥＮＡＮＡf9EZzgpNCY
1056Please respect copyright.ＰＥＮＡＮＡCAOHVs1NsZ
1056Please respect copyright.ＰＥＮＡＮＡakSlmAMxNZ
同時，腸道亦是寄生蟲的蝸居，飲用不乾淨水的話有機會讓血吸蟲寄生在腸道之中，引起血吸蟲病（Schistosomiasis)，為全球第二大僅次於瘧疾(Malaria)的寄生蟲病。1056Please respect copyright.ＰＥＮＡＮＡ8eic2EZbrg
1056Please respect copyright.ＰＥＮＡＮＡD8wOJNogni
1056Please respect copyright.ＰＥＮＡＮＡ0ZohdMhRrZ
（圖2）近日，有科學家發表文章（Ref1)，他們研發出一款口服藥物，主要利用豬隻作為動物模型，證實豬隻吞下藥物後的12分鐘會腸道形成厚膜。1056Please respect copyright.ＰＥＮＡＮＡuFzZt0rooD
1056Please respect copyright.ＰＥＮＡＮＡBaj9uAepLn
1056Please respect copyright.ＰＥＮＡＮＡKWkeDt37fb
此厚膜不會在其他器官上形成，而在24小時後厚膜亦會自然脫落，排出體外。1056Please respect copyright.ＰＥＮＡＮＡw2OyPg5rnz
1056Please respect copyright.ＰＥＮＡＮＡGB0los8ssB
（圖3）根據口服藥物的配方不同，厚膜的特性亦能隨之轉變。1056Please respect copyright.ＰＥＮＡＮＡ5b9srHWDai
1056Please respect copyright.ＰＥＮＡＮＡRkD3WdlDTh
1056Please respect copyright.ＰＥＮＡＮＡ8vDq8w9ebS
厚膜可配載消化乳糖酵素(Lactase)，對比沒有厚膜，能增強20倍酵素的能力，可消除Lactose Intolerance的問題。1056Please respect copyright.ＰＥＮＡＮＡGvdUaAUcKs
1056Please respect copyright.ＰＥＮＡＮＡqu08IMzkdX
而增強厚膜密度的話，亦可減少腸道吸收葡萄糖七成能力，這特點尤其受益於糖尿病人，能大幅度阻上血糖飄升。1056Please respect copyright.ＰＥＮＡＮＡUfQMBWCGdM
1056Please respect copyright.ＰＥＮＡＮＡZzB5esAaLY
另外，厚膜亦可配載殺寄生蟲藥(Praziquantel)，增加藥物滯留在腸道的時間，更有效率殺滅寄生蟲。1056Please respect copyright.ＰＥＮＡＮＡxtb2rf6jgR
1056Please respect copyright.ＰＥＮＡＮＡUsGZrOBAGW
1056Please respect copyright.ＰＥＮＡＮＡyrbyTdOsyb
（圖4）最為振奮的是，此方法在人類腸道組織亦見效，而且藥物對各種實驗室人體細胞亦無呈現有害效果。1056Please respect copyright.ＰＥＮＡＮＡFpvlwEwKts
1056Please respect copyright.ＰＥＮＡＮＡxEWOSAJ5QB
1056Please respect copyright.ＰＥＮＡＮＡ0XmkKKhFtM
老鼠服用藥物28日後，體重血壓等一切正常。1056Please respect copyright.ＰＥＮＡＮＡZU73ZER0cX
1056Please respect copyright.ＰＥＮＡＮＡKS6ceUHWqN
若然此藥物能進一步在人類進行試驗的話，確立藥物運作正常及不會帶來任何副作用或安全問題的話，絕對大有潛質會成為治理糖尿病的新一代藥物。1056Please respect copyright.ＰＥＮＡＮＡZEJzdB3JLI
1056Please respect copyright.ＰＥＮＡＮＡDGGwxW1LeL
如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。1056Please respect copyright.ＰＥＮＡＮＡrxysDt4EFi
1056Please respect copyright.ＰＥＮＡＮＡuA9cCgg4vE
Link: https://www.penana.com/story/66244/%E7%A7%91%E6%99%AE%E5%B0%88%E6%AC%84-%E8%96%AF%E4%B8%8D%E6%8F%80%E5%96%AE/toc1056Please respect copyright.ＰＥＮＡＮＡgiwlc4pBt1
1056Please respect copyright.ＰＥＮＡＮＡU4DzOMFzCj
同時亦可以在Penana網站裡按「買一嚿/半嚿薯仔」，以課金的方式推動我繼續搜羅資料寫文，多謝。1056Please respect copyright.ＰＥＮＡＮＡPXKKBJzfmA
1056Please respect copyright.ＰＥＮＡＮＡOUL4k9mcen
Link:1056Please respect copyright.ＰＥＮＡＮＡXf2YtwsuSO
https://www.penana.com/user/27349/%E8%96%AF%E4%BB%94%E8%81%9E%E8%8C%B1%E8%8E%89/portfolio1056Please respect copyright.ＰＥＮＡＮＡtEAIp5vlfL
1056Please respect copyright.ＰＥＮＡＮＡM1T9ALyuKg
1056Please respect copyright.ＰＥＮＡＮＡfi3JhMQZd3
有興趣接收科學資訊的話，歡迎follow IG: potatopigtongue。1056Please respect copyright.ＰＥＮＡＮＡd7q5bkb0f5
1056Please respect copyright.ＰＥＮＡＮＡSytpK4MFEi
1056Please respect copyright.ＰＥＮＡＮＡGp2uOGFVb4
1056Please respect copyright.ＰＥＮＡＮＡoka8dvsSzh
Ref1:https://stm.sciencemag.org/content/12/558/eabc0441

ns216.73.216.212da2

介面主題:

字體大小:

行距:

段距:

自動加載下一章